Anti - Mouse, CD68 Clone KP1
- Known as:
- Anti - Mouse, CD68 Clone KP1
- Catalog number:
- 61-0094-2
- Product Quantity:
- 0.2mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse CD68 Clone KP1
Related genes to: Anti - Mouse, CD68 Clone KP1
- Gene:
- CD68 NIH gene
- Name:
- CD68 molecule
- Previous symbol:
- -
- Synonyms:
- SCARD1, macrosialin, GP110, DKFZp686M18236, LAMP4
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-11
- Date modifiied:
- 2016-10-05
Related products to: Anti - Mouse, CD68 Clone KP1
Related articles to: Anti - Mouse, CD68 Clone KP1
- Rosai-Dorfman Disease (RDD) is a rare histiocytic disorder typically affecting lymph nodes. Extranodal RDD is uncommon, and isolated central nervous system (CNS) or spinal disease is particularly rare, limiting guidance on diagnosis and management. - Source: PubMed
Publication date: 2026/05/28
Ramesh RithvikOsorio Robert CPekmezci MelikeBoreta LaurenDatta DebajyotiAlan Nima - Pro-inflammatory cytokines, TNF and IL-1B, are essential for testicular homeostasis. Diacerein, an anti-inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown. - Source: PubMed
Publication date: 2026/05/29
Jesus Elide Loise Freitas deSilva André Acácio Souza daAkinsomisoye Olumide StephenSilva Erick J RCerri Paulo Sérgiode Oliveira Salmo AzambujaSasso-Cerri Estela - Malakoplakia is a rare chronic granulomatous disorder predominantly occurring in immunocompromised patients, with renal parenchymal involvement being exceptionally rare, likely because of dysfunctional macrophage clearance of bacteria. Here, we report a case of a 69-year-old woman with elevated creatinine levels and bilateral kidney lesions, but no identifiable immunosuppressive factors. was isolated from urine analysis. Histopathological examination showed nearly complete replacement of renal parenchyma by 3 distinct morphological zones: a granulomatous area rich in CD68 macrophages and giant cells with eosinophilic granular cytoplasm, an inflammatory zone dominated by mixed inflammatory cells, and a collagen-dominant fibrotic zone. Numerous Michaelis-Gutmann (MG) bodies with significant size variation (maximum dimension 187 μm × 96 μm) were observed. Electron microscopy showed abnormally enlarged lysosomes containing fibrillary components, as well as crystalloid or targetoid bodies, representing different developmental stages of MG bodies. After treatment with levofloxacin and prednisone, the patient's creatinine levels improved, and renal cortical thickness normalized. This case not only demonstrates the histological features of malakoplakia at different stages but also shows the ultrastructural progression of MG bodies, suggesting that malakoplakia should be considered in the differential diagnosis of elderly patients with unexplained kidney function decline. - Source: PubMed
Publication date: 2026/04/21
Ren Ya-LiQiu De-JunLi Xin-LunWang Su-Xia - Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental conditions characterized by variations in social interactions, stereotyped behaviors, and sensory processing differences. Altered tactile and auditory sensory processing is among the most frequently observed phenotypes in ASD animal models, particularly in Shank3 gene knockout rodents. Previous research has focused extensively on neural activity associated with Shank3 deficiency and sensory dysregulation, but the role of glial cells, especially microglia, has been largely overlooked. Microglia, the central nervous system's primary immune cells, are crucial for regulating neural activity throughout development and adulthood. To address this gap, we used immunofluorescence microscopy to examine microglial morphology, density, and the fluorescence intensity of IBA1 and CD68 in adult Shank3 knockout and wild type mice, focusing on brain regions primarily involved in the acoustic startle circuit, while including the somatosensory cortex as a control region. We examined six brain regions involved in auditory and tactile sensory processing: the somatosensory cortex, central nucleus of the amygdala (CeA), caudal pontine reticular nucleus (PnC), reticulotegmental nucleus (RtTg), inferior colliculus(IC), and cochlear nucleus (CN). Our findings showed a 39% increase in IBA1 expression in the CeA (p = 0.01) and a 13% increase in microglial density in the PnC (p = 0.02). However, we found no evidence of robust microglial activation, as indicated by the absence of morphological changes or alterations in CD68 expression across the examined regions. These results indicate that moderate microglial alterations in the Shank3 mouse model may be circuit-dependent rather than a global phenomenon across all sensory modalities, warranting further investigation into the interplay between glial cells and sensory circuit dysfunction. - Source: PubMed
Publication date: 2026/05/18
Ren XinHavekes RobbertKas Martien J H - Glioblastoma remains a highly aggressive brain tumour with poor prognosis despite advances in standard therapies. The tumour microenvironment, comprising tumour cells, immune cells - predominantly tumour-associated microglia and macrophages (TAMMs) and extracellular matrix components, critically influences tumour progression and therapy resistance. TAMMs promote immunosuppression, tumour invasion, and angiogenesis, while T cells, although fewer, are suppressed by glioblastoma-mediated mechanisms, limiting anti-tumour immunity. Advances in non-invasive imaging technologies, including magnetic resonance imaging, positron emission transmission (PET), and optical methods, enable visualisation and characterisation of the immune microenvironment in vivo. Imaging agents targeting TAMM markers such as TSPO, CD163, CD68, CD206, and CX3CR1 have facilitated the mapping of immune cell distribution and functional states within gliomas. Additionally, emerging PET tracers allow monitoring of T-cell infiltration, activation, and exhaustion, providing insights into immunotherapy responses. Despite challenges such as blood brain barrier permeability, tracer specificity, and regulatory hurdles, multimodal imaging combined with radiomics and spatial transcriptomics offers promising avenues for personalised therapeutic strategies. Future directions focus on integrating immune cell imaging with theranostic approaches, nanoparticle delivery systems, and longitudinal monitoring to overcome tumour heterogeneity and improve treatment efficacy. This review highlights the evolving landscape of immune cell imaging in gliomas, emphasising its potential to enhance diagnosis, guide immunotherapy, and ultimately improve patient outcomes. - Source: PubMed
Publication date: 2026/05/27
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