Anti - Mouse, MLH1 Clone ZM001
- Known as:
- Anti - Mouse, MLH1 Clone ZM001
- Catalog number:
- 60-0075
- Product Quantity:
- 6 mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse MLH1 Clone ZM001
Related genes to: Anti - Mouse, MLH1 Clone ZM001
- Gene:
- MLH1 NIH gene
- Name:
- mutL homolog 1
- Previous symbol:
- COCA2
- Synonyms:
- HNPCC, FCC2, HNPCC2
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2019-04-23
Related products to: Anti - Mouse, MLH1 Clone ZM001
Related articles to: Anti - Mouse, MLH1 Clone ZM001
- Mismatch repair deficiency (MMRd) is a key diagnostic and predictive biomarker, yet its mechanisms in upper gastrointestinal (UGI) and pancreaticobiliary (PB) malignancies remain incompletely defined. - Source: PubMed
Publication date: 2026/09/11
Davidson SarahGibson Joanna A - Immune checkpoint inhibitors (ICIs) are standard treatment for mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) gastrointestinal tumors but resistance remains relevant. Secondary actionable fusions may be enriched in MutL homolog 1 (MLH1)-deficient colorectal cancer (CRC) with mitogen-activated protein kinase wild-type biology, whereas their prevalence in non-CRC tumors and impact on ICI outcomes remain poorly defined. We evaluated secondary fusions in MLH1-deficient dMMR/MSI-H tumors treated with pembrolizumab. - Source: PubMed
Publication date: 2026/09/01
Martínez Lago NSánchez Ares MCarral Maseda APérez Martelo MCovela Rúa MFernández Montes Ade la Cámara Gómez JGonzález Villarroel PReboredo López MPadín Iruegas M EAbdulkader Nallib I - Medullary carcinoma of the colon is a rare histological subtype of poorly differentiated or undifferentiated adenocarcinoma, with a reported incidence of 0.05%-0.08%. It typically affects older women, is more frequently located in the right colon, and is characterized by a high prevalence of mismatch repair deficiency, particularly microsatellite instability (MSI). In comparison to other poorly differentiated adenocarcinomas, medullary carcinoma generally exhibits a lower rate of lymph node or distant metastasis and carries a relatively favorable prognosis. Due to its recent classification and rarity, reported cases remain limited. We herein describe a case of surgically resected medullary carcinoma of the ascending colon in an older woman, along with a brief review of the relevant literature. - Source: PubMed
Publication date: 2026/09/05
Kishimoto AyanaYamamoto TetsuTaniura TakahitoIshitobi KazunariInoue KeisukeKaji ShunsukeTanaka TakayukiMatsubara TakeshiHidaka Masaaki - Neurotrophic receptor tyrosine kinase () fusion-positive colorectal cancer (CRC) represents a rare molecular subset of CRC. We report an exceptional case of a collision tumor composed of two anatomically adjacent but histologically and genomically distinct primary colorectal carcinomas, each giving rise to a corresponding metastasis. Comprehensive histopathologic and molecular analyses demonstrated that one primary tumor and its matched metastasis consisted predominantly (> 90%) of a solid carcinoma harboring a fusion, high microsatellite instability (MSI-H), elevated tumor mutational burden (TMB), and loss of MLH1 and PMS2 expression by immunohistochemistry. In contrast, the second primary tumor and its corresponding metastasis exhibited conventional adenocarcinoma morphology with mucinous differentiation, lacked an fusion, and carried canonical driver mutations in , and . This case underscores the importance of integrated histopathologic and molecular evaluation in CRCs with heterogeneous morphology, as the identification of multiple, genomically distinct tumor components may have significant diagnostic, prognostic, and therapeutic implications. - Source: PubMed
Publication date: 2026/08/26
Sirek AndrejAmann Valerie CUzun SarpBubendorf LukasRosenberg RobertBurri EmanuelHäuptle PirminRoma LucaMertz Kirsten D - Lynch syndrome screening may be complicated by discordant tumor testing results. We report a family carrying the germline c.931A>G (p.Lys311Glu) variant in which both the proband and his father had colorectal tumors with retained mismatch repair protein expression by immunohistochemistry but microsatellite instability-high status on tumor sequencing. The proband was a 39-year-old man with colorectal cancer and a family history fulfilling Amsterdam criteria. Paired tumor-blood sequencing identified MSI-H, high tumor mutational burden, and the germline variant. The father showed a similar molecular profile and achieved substantial lesion regression after immunotherapy. Family studies demonstrated segregation of the variant across three generations. This case highlights that preserved tumor MMR immunostaining does not exclude Lynch syndrome when clinical suspicion is high. Concurrent MSI and MMR immunohistochemistry, interpreted together with tumor sequencing and germline testing, may improve diagnosis, treatment selection, and familial risk assessment. - Source: PubMed
Publication date: 2026/09/09
Cai JingjingLi ZhuoyingHan TingtingGuo YinjinDu YaxiLiu DanLiu Xin