RPMI 1640 w_ L_Glutamine _ 500ml
- Known as:
- RPMI 1640 w_ L_Glutamine _ 500ml
- Catalog number:
- LM-R1640/500
- Category:
- -
- Supplier:
- Biosera
- Gene target:
- RPMI 1640 w_ L_Glutamine _ 500ml
Related genes to: RPMI 1640 w_ L_Glutamine _ 500ml
- Gene:
- CCDC40 NIH gene
- Name:
- coiled-coil domain containing 40
- Previous symbol:
- -
- Synonyms:
- FLJ20753, KIAA1640, FLJ32021, CILD15, FAP172
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-13
- Date modifiied:
- 2018-11-15
Related products to: RPMI 1640 w_ L_Glutamine _ 500ml
0.5M EDTA, pH 8.0, Ultra Pure Grade,0.5M EDTA, pH 8.0, Ultra Pure Grade, 500ml Ready-made Buffers1 x 400ml Bottle Adapters For 500ml Rectangular Buckets1.68 NIST-Traceable pH Buffer 500ml10% Sodium Dodecyl Sulfate (SDS) Solution, Biotechnology Grade,10% Sodium Dodecyl Sulfate (SDS) Solution, Biotechnology Grade, 500ml Ready-made Buffers10.0 NIST-Traceable pH Buffer 500ml12 x 15ml Conical Adapters For 500ml Rectangular Buckets12.88 mS/cm Conductivity Stnrd 500ml1413 uS/cm Conductivity Stndrd 500ml16 x 3-15ml Adapters For 500ml Rectangular Buckets16 x 7-17ml Adapters For 500ml Rectangular Buckets1640
18 x 2.6-7ml Adapters For 500ml Rectangular Buckets1M Sodium Hydroxide, Biotechnology Grade, Related articles to: RPMI 1640 w_ L_Glutamine _ 500ml
- Spermiogenesis requires extensive molecular and structural remodeling to produce motile sperm. Mutations in the testis-specific RNA methyltransferase NSUN7 are associated with defective fibrous sheath, impaired sperm motility, and male infertility. However, the underlying molecular mechanisms remain poorly understood. Here, we performed proteomic profiling of sorted, elongated, and round spermatids, as well as mature spermatozoa from Nsun7 knockout mice. We showed that NSUN7 is present at all stages of spermiogenesis and is most abundant in round spermatids, which corresponds to the formation of the flagellum and fibrous sheath assembly. Loss of NSUN7 altered the abundance of proteins essential for dynein arm assembly (PIH1D3, CCDC103, CCDC40), intraflagellar transport (IFT122), and fibrous sheath organization (AKAP3, AKAP4, ROPN1L). We also showed that the previously detected impaired retention of cytoplasm in elongated spermatids may be caused by plectin accumulation. Interestingly, no statistically significant changes were found in mature sperm proteomes upon Nsun7 inactivation. Our findings support a model in which NSUN7 primarily stabilizes protein complexes and coordinates flagellar assembly. This indicates that NSUN7 is a critical regulator of spermiogenesis, and its malfunction is a contributing factor to male infertility. - Source: PubMed
Publication date: 2025/12/25
Buev Vitaly SGuseva Ekaterina ARubtsova Maria PPriymak Anastasia VNovikova Svetlana EAverina Olga APermyakov Oleg AGrigoryeva Olga OManskikh Vasily NZgoda Victor GDontsova Olga ASergiev Petr V - To characterize the clinical features and genetic variant spectrum of adult patients with primary ciliary dyskinesia (PCD) in China and to explore phenotypic differences across distinct genotypes, with a focus on comparisons among commonly detected genetic variants. This study was a single-center, retrospective cohort investigation that enrolled 73 adult patients diagnosed with PCD at the Second Xiangya Hospital of Central South University between January 2015 and March 2025. Females patients comprised 58.9% (43/73) of the cohort, and the median age at diagnosis was 30.0 (23.5-39.0) years. Demographic and clinical data were collected, and follow-up was conducted by telephone to assess outcomes. Phenotypic differences were compared across common genotypes (, , , and ). Continuous variables were summarized as (, ) and analyzed using non-parametric tests, while categorical variables were assessed using Fisher's exact test. Among the 73 enrolled patients, 71 were diagnosed with PCD through genetic testing, and 2 were diagnosed by transmission electron microscopy. A history of consanguinity was reported in 47.9% (35/73) of cases. Situs inversus was present in 50.7% (37/73). CT demonstrated rhinosinusitis in 95.5% of patients (64/67), and bronchiectasis was observed in all patients (100%, 73/73). The most frequently identified genotypes were (17/71), (10/71), (5/71), and (5/71). Among these genotypes, significant differences were observed in the prevalence of female infertility (<0.001) and the severity of bronchiectasis as measured by the Reiff score (=0.013). Over a median follow-up period of 5.5 (2.3-6.8) years, seven patients (9.6%) died from pulmonary infections complicated by respiratory failure. Adult patients with PCD exhibit substantial clinical and genetic heterogeneity, accompanied by significant genotype-phenotype correlations. - Source: PubMed
Zhou X LLei CYang D HLiu YHe JFan HWang LGuo M QMa KLu X YYang B YGuo TLuo H - Inborn Errors of Immunity (IEI) often lead to recurrent infections, immune dysregulation, and an increased risk of malignancies. Due to the heterogeneity in IEI presentations, personalized monitoring is essential for early detection of non-infectious complications. This study aims to document the characteristics and prevalence of malignancies in IEI patients. - Source: PubMed
Publication date: 2025/09/25
Gumusburun ReyhanYıldırım OnurcanKarakoc MetehanOkan KasımInan SinemDalgıc Ceyda TunakanAkten Hatice SerpilBogatekin GulhanBulut GoktenDemir MeryemAytac HasibeCamyar AsumanOzısık MelihDemir DeryaSoyer NurSoylu MehmetUysal Funda ElmasAykut AycaDurmaz AsudeOzgul SemihaSin Aytul ZerrinArdeniz Omur - Primary ciliary dyskinesia is a rare, inherited disease, and over 60 genes have been linked to motile ciliopathies. During the past quarter century, our understanding of the complex genetics and biological function of motile cilia has greatly advanced. - Source: PubMed
Publication date: 2025/09/12
Horani AmjadWee WallaceOmran HeymutFerkol Thomas - Primary ciliary dyskinesia (PCD) is a rare genetic condition characterised by abnormal ciliary motility, primarily affecting the respiratory tract. Despite its clinical significance, there is currently no gold standard for PCD diagnosis. This study aims to address this diagnostic challenge by evaluating a comprehensive approach in a large cohort of patients with suspected PCD. - Source: PubMed
Publication date: 2025/07/31
Carretero-Vilarroig LidónBlanco-Máñez RosanaMuñoz-Fernández NoeliaIbáñez IsabelBerzal-Serrano AlbaReula AnaGarcía-Bohórquez BelénAller ElenaGarcía-García GemaMillán Jose MArmengot-Carceller MiguelJaijo Teresa