MTB Real-TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209)
- Known as:
- MTB Real-TM Resistance 4 (Multiplex PCR test kit preamplification resistance rifampicine (RIF) isoniazide (INH) genes rpoB 531, katG 315, inhA 209)
- Catalog number:
- B422-50FRT RG, iQ, MX, SC, A
- Product Quantity:
- 50 tests
- Category:
- -
- Supplier:
- Sacace
- Gene target:
- MTB Real- Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) isoniazide (INH) genes rpoB 531 katG 315 inhA 209)
Ask about this productRelated genes to: MTB Real-TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209)
- Gene:
- ACSF2 NIH gene
- Name:
- acyl-CoA synthetase family member 2
- Previous symbol:
- -
- Synonyms:
- FLJ20920, ACSMW
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2015-08-26
- Gene:
- ANGPTL8 NIH gene
- Name:
- angiopoietin like 8
- Previous symbol:
- C19orf80
- Synonyms:
- TD26, RIFL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2011-08-04
- Date modifiied:
- 2015-11-11
- Gene:
- BDH2 NIH gene
- Name:
- 3-hydroxybutyrate dehydrogenase 2
- Previous symbol:
- DHRS6
- Synonyms:
- UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1
- Chromosome:
- 4q24
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-22
- Date modifiied:
- 2016-12-12
- Gene:
- C8orf33 NIH gene
- Name:
- chromosome 8 open reading frame 33
- Previous symbol:
- -
- Synonyms:
- FLJ20989
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-19
- Date modifiied:
- 2017-07-12
- Gene:
- CCDC30 NIH gene
- Name:
- coiled-coil domain containing 30
- Previous symbol:
- -
- Synonyms:
- FLJ20972, PFD6L, LOC728621
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-07-09
- Date modifiied:
- 2015-08-24
Related products to: MTB Real-TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209)
Related articles to: MTB Real-TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209)
- Effective management of drug-resistant tuberculosis requires molecular assays that not only detect but also identify resistance-associated variants, support drug-level interpretation, and indicate when broader confirmatory testing is needed. This narrative review applies a mutation-to-drug-to-decision framework to distinguish assay validity, exact-variant detection, drug-level inference, and decision impact. We synthesize evidence on target accessibility, minority-allele preservation, multiplexing, direct-specimen testing, and sequencing enrichment, emphasizing how these factors shape clinical interpretability. Current evidence remains dominated by analytical studies, isolate-based evaluations, and small direct-specimen investigations, with prospective multicenter treatment-impact validation still lacking. Population-level benchmarks indicate incomplete biological coverage for compact target regions, reaching approximately 92.6% for RRDR-based rifampicin detection, 85.4% for codon 315 plus the promoter for isoniazid, and 84.7%-88.2% for -based fluoroquinolone detection. Allele-specific CRISPR is therefore best suited to rapid rule-in of selected resistance-associated variants, while dispersed or heterogeneous mechanisms require broader molecular or phenotypic assessment. CRISPR should complement WHO-recommended rapid molecular testing and targeted next-generation sequencing rather than replace established molecular or phenotypic methods. - Source: PubMed
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