AKT2, Mab anti_; Clone 1F3
- Known as:
- AKT2, Mab anti_; Clone 1F3
- Catalog number:
- YSRTMCA5507Z
- Product Quantity:
- 0.1 mg.
- Category:
- -
- Supplier:
- Accu
- Gene target:
- AKT2 Mab anti_; Clone 1F3
Related genes to: AKT2, Mab anti_; Clone 1F3
- Gene:
- AKT2 NIH gene
- Name:
- AKT serine/threonine kinase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-05
- Date modifiied:
- 2016-10-05
- Gene:
- GOLGB1 NIH gene
- Name:
- golgin B1
- Previous symbol:
- -
- Synonyms:
- GCP, GCP372, giantin, GOLIM1
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-05
- Date modifiied:
- 2016-10-05
- Gene:
- SERPINA1 NIH gene
- Name:
- serpin family A member 1
- Previous symbol:
- PI
- Synonyms:
- AAT, A1A, PI1, alpha-1-antitrypsin, A1AT, alpha1AT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- SERPINB1 NIH gene
- Name:
- serpin family B member 1
- Previous symbol:
- ELANH2
- Synonyms:
- EI, PI2, anti-elastase
- Chromosome:
- 6p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-27
- Date modifiied:
- 2016-04-06
Related products to: AKT2, Mab anti_; Clone 1F3
Related articles to: AKT2, Mab anti_; Clone 1F3
- Herpes simplex virus 1 (HSV-1) infection contributes to immunopathogenic diseases and lacks an effective vaccine. Improving antigen presentation is key to better vaccine strategies and more robust immune responses. Here, we show that optineurin (OPTN), an autophagy receptor traditionally involved in protein recycling, unexpectedly stabilizes RICTOR (mechanistic target of rapamycin complex 2 [mTORC2]), a crucial step in enhancing MHC class II surface expression in dendritic cells. OPTN regulates the AKT/mTOR/signal transducer and activator of transcription 3 (STAT3) pathway, with the AKT2 isoform playing a central role. Using single-cell RNA sequencing (scRNA-seq) and transgenic mouse models, we identify the mechanistic details of this pathway. Dysregulation impairs antigen presentation, weakening immunity and vaccine efficacy. Our findings uncover a previously unknown function of OPTN and highlight its role in coordinating innate and adaptive immune defenses, with implications for vaccine development and immune response modulation in HSV-1 and other viral and bacterial diseases. - Source: PubMed
Publication date: 2026/04/16
Kadam RashmiPatil ChandrashekharFeferman LeonidMaienschein-Cline MarkChlipala GeorgeBorole PiyushBhattacharya IlinaOrameh ChimaNyugen TaraTseng HenryShukla Deepak - Glioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from , has shown anti-tumor potential. Gab2, a tyrosine kinase substrate, is implicated in glioma pathogenesis; however, the mechanism by which GS-Rh2 might inhibit glioma cell migration and invasion via the Gab2/Akt2 pathway remains unexplored. - Source: PubMed
Publication date: 2026/04/01
Sun WeiLi RuifangWang LinjuanHan WenjieLi JiakeXu ShuangliSun Xiuning - This study, based on the network pharmacology approach, aims to systematically explore the potential molecular mechanism of Cangshu Diantong Pill in treating type 2 diabetes (T2DM), and particularly emphasises the theoretical correlation between its mechanism of action and the modern metabolic abnormality diagnostic indicators. - Source: PubMed
Publication date: 2026/04/16
Zeng JiaYin DongfangYan FangLi Shougen - The phosphatidylionsitol 3-kinase (PI3K)-v-akt murine thymoma viral oncogene homolog (AKT)-mammalian target of rapamycin (mTOR) pathway has been extensively studied in lung adenocarcinomas (LUAD). This study aimed to explore the correlation between this pathway and the tumor microenvironment. - Source: PubMed
Fu ZiyiMo LvLi PeiyongCai YanHuang HuitingZhan ShaofengLi Junxiong - The mammalian heart critically depends on oxidative metabolism of fatty acids, glucose, ketones, and amino acids to meet its extensive ATP demands. AKT/protein kinase B plays a central role in regulating cell growth and metabolism by coordinating an anabolic metabolism in response to insulin or IGF1, particularly by elevating glucose uptake and mTOR activity. Here, we investigated the effect of simultaneous deletion of the two major cardiac isoforms AKT1 and AKT2 on the function and metabolism of the adult mouse heart. Inducible cardiomyocyte specific AKT1 AKT2 double knockout mice developed a rapidly progressing and lethal heart failure with extensive cardiomyocyte atrophy. Metabolic analyses of substrate-specific respiration of mitochondria (respirometry) and of isolated cardiac tissue (Seahorse flux analysis) demonstrated that fatty acid metabolism was severely compromised, whereas glucose metabolism was less affected. Volume-specific in vivo NMR spectroscopy and CrCEST (Creatine chemical exchange saturation transfer) imaging revealed a drop of the cardiac phosphocreatine/ATP ratios from 2 to 1.5, indicating severe energetic depletion. Transcriptomic and proteomic studies showed that genes of the TCA cycle, β-oxidation, and oxidative phosphorylation were coordinately down-regulated. Moreover, AKT1/AKT2 deficient cardiomyocytes lost the ability to store fatty acids in lipid droplets (LDs) due to an early loss of perilipins and other proteins involved in LD generation and function. In conclusion, our data show that general, isoform-independent AKT signaling in cardiac myocytes is indispensable for preservation of cardiac fatty acid metabolism and energy supply. - Source: PubMed
Publication date: 2026/04/11
Gödecke StefanieHeinen AndréAppel TimMüller Phil-TorbenStemmer TimMüller DanielaFlögel UliHerebian DiranSolari Fiorella ADeenen ReneKöhrer KarlSickmann AlbertGödecke Axel