Goat Anti-Human CES1
- Known as:
- Goat Antibody toHuman CES1
- Catalog number:
- 129-10193
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Goat Anti-Human CES1
Related genes to: Goat Anti-Human CES1
- Gene:
- CES1 NIH gene
- Name:
- carboxylesterase 1
- Previous symbol:
- -
- Synonyms:
- HMSE, CES2, HMSE1, SES1, CEH, CES1A1, CES1A2
- Chromosome:
- 16q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2016-10-05
- Gene:
- CES1P1 NIH gene
- Name:
- carboxylesterase 1 pseudogene 1
- Previous symbol:
- CES4
- Synonyms:
- PCE-3, CESR, CES1A3
- Chromosome:
- 16q12.2
- Locus Type:
- pseudogene
- Date approved:
- 2004-02-20
- Date modifiied:
- 2013-07-10
Related products to: Goat Anti-Human CES1
Related articles to: Goat Anti-Human CES1
- Methylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication. Variability in response and occurrence of adverse events with methylphenidate use may be due to several factors, including drug-drug interactions as well as pharmacogenetic differences resulting in pharmacokinetic and/or pharmacodynamic variances within the general population. The objective of this study was to analyze the effect of carboxylesterase 1 () variants on the frequency of adverse effects and dosing requirements of methylphenidate in children with ADHD. - Source: PubMed
Publication date: 2023/01/18
Brown Jacob TBeery NancyTaran AlliseStevens TylerHenzler ChristineBadalamenti JonathanRegal RonMcCarty Catherine A - Variants in the gene encoding carboxylesterase 1 may affect the metabolism of enalapril to the active metabolite enalaprilat. It was shown that the A allele of rs71647871 and the C allele of rs2244613 led to a decrease in plasma enalaprilat concentrations. This study aimed to estimate the effect of structural haplotypes of containing the pseudogene or a hybrid of the gene and the pseudogene on the pharmacokinetics of enalapril. We included 286 Caucasian patients with arterial hypertension treated with enalapril. Genotyping was performed using real-time PCR and long-range PCR. Peak and trough plasma enalaprilat concentrations were lower in carriers of . The studied haplotypes were in linkage disequilibrium with rs2244613: generally, the A allele was in the haplotype containing the , and the C allele was in the haplotype with the . Thus, carriers of have reduced CES1 activity against enalapril. Linkage disequilibrium of the haplotype containing the or with rs2244613 should be taken into account when genotyping the gene. - Source: PubMed
Publication date: 2022/11/27
Ikonnikova AnnaKazakov RuslanRodina TatianaDmitriev ArtemMelnikov EvgeniyZasedatelev AlexanderNasedkina Tatiana - This study aimed to measure the DNA methylation state of thousands of CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular disease (CVD). Twin 1 had suffered myocardial infarction, while the other was healthy. - Source: PubMed
Koseler AylinMa FeiyangKilic Ismail DoguMorselli MarcoKilic OguzPellegrini Matteo - Development of a specific procedure for genotyping of CES1A1 (CES1) and CES1A2, a hybrid of CES1A1 and the pseudogene CES1P1. - Source: PubMed
Publication date: 2018/02/19
Bjerre DitteBerg Rasmussen HenrikIndices Consortium The - The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange with CES1 and in the formation of hybrid genes including the carboxylesterase 1A2 gene (CES1A2). Hence, the CES1 region is complex. Using in silico PCR and alignment, we assessed the specificity of PCR-assisted procedures for genotyping CES1, CES1A2 and CES1P1 in studies identified in PubMed. We identified 33 such studies and excluded those that were not the first to use a procedure or lacked sequence information. After this 17 studies remained. Ten of these used haplotype-specific amplification, restriction enzyme treatment or amplicon sequencing, and included five that were predicted to lack specificity. All procedures for genotyping of single nucleotide polymorphisms in eight studies lacked specificity. One of these studies also used amplicon sequencing, thus being present in the group above. Some primers and their intended targets were mismatched. We provide experimental evidence that one of the procedures lacked specificity. Additionally, a complex pattern of segmental duplications in the CES1 region was revealed. In conclusion, many procedures for CES1, CES1A2 and CES1P1 genotyping appear to lack specificity. Knowledge about the segmental duplications may improve the typing of these genes. - Source: PubMed
Rasmussen Henrik BergMadsen Majbritt Busk