Rat Anti-Mouse CDw199
- Known as:
- Rat Antibody toMouse CDw199
- Catalog number:
- 129-10184
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Rat Anti-Mouse CDw199
Related genes to: Rat Anti-Mouse CDw199
- Gene:
- CCR9 NIH gene
- Name:
- C-C motif chemokine receptor 9
- Previous symbol:
- GPR28
- Synonyms:
- GPR-9-6, CDw199
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-17
- Date modifiied:
- 2016-03-14
Related products to: Rat Anti-Mouse CDw199
Related articles to: Rat Anti-Mouse CDw199
- B cells contribute to the pathogenesis of food allergies as they induce allergen-specific antibody production. Clinically-used allergen-specific immunotherapies have shown to induce regulatory B cell (Bregs) subsets as well as target and reduce allergy-driving B cell functions. This report aims to elucidate the contribution of regulatory B cells to an allergen-encapsulating nanoparticle (aeNP) immunotherapy in a murine model of food allergy. In this model, B cells directly associated with aeNPs. CD20+ B cell depletion after aeNP treatment increased the number of mice with severe allergic reactions during oral food challenges and reduced the expansion of regulatory immune cells including CD103+ dendritic cells (DCs) and CCR9+ gut-homing regulatory T cells, indicating that B cells are a component of aeNP immunomodulation. B cell communication in the gastrointestinal tract of aeNP-treated mice identified CD23 signaling as a potential inducer of regulatory CD103+ DC functions and disrupter of allergy-driving B cell-T cell communication. These tolerogenic signaling patterns were also identified in IL-10+ B cells, which have been known to impart regulatory immune effects in both murine and human disease. Ultimately, B cells are a component of the complex immunomodulation leading to aeNP efficacy at reducing allergic reactivity. - Source: PubMed
Publication date: 2026/06/09
Rad Laila MSaunders Michael NWilliams Laura AJanczak Katarzyna WDorsett Chris LGriffin Kate VBealer Elizabeth JMa Jeffrey ATillery Sayre ARoy JyotirmoyMiller Stephen DO'Konek Jessica JShea Lonnie D - Intraepithelial lymphocytes (IELs) are among the largest lymphocyte populations in the body and play a crucial role in maintaining the integrity of epithelial barriers at mucosal sites, which are highly immunostimulatory. Therefore, understanding how these cells are generated, localized within the epithelium, and contribute to barrier immunity is essential. Although most research on IEL biology has focused on the small intestine, IELs are also present in the large intestinal epithelium. Additionally, the homing receptor-ligand pairs that regulate T cell localization in the lamina propria beneath the epithelium differ between the small and large intestines: CCL25-CCR9 in the small intestine and C10ORF99-GPR15 in the large intestine. CCL25-CCR9 is also necessary for proper localization of IELs in the small intestine, but the mechanisms controlling IEL localization in the large intestine remain unknown. Here, we demonstrate that the C10ORF99-GPR15 pathway is crucial for the presence of TCR + natural IELs in the large intestinal epithelium, a process that requires epithelium-derived C10ORF99 (GPR15L). - Source: PubMed
Publication date: 2026/06/01
O'Connor Gerald JChoi Jihae CVan Nguyen TKlutkoski Anthony MRobertson Lucia CKim Sangwon V - This study aimed to investigate the immunomodulatory effects of selenium-modified Hericium erinaceus polysaccharides on intestinal immunity and Newcastle disease (ND) vaccine responses in chickens. Selenium modification of HEP (SHEP) was confirmed via SEM, TEM, FT-IR, Monosaccharide composition, Molecular weight, stability, release assay and the selenium content of SHEP. In vitro, SHEP-M group significantly decreased ROS, CD86, IL-1β, IL-6 and TNF-α levels, and enhanced CD206 levels. In vivo, chickens immunized with Newcastle disease vaccine showed that 160 mg/kg SHEP significantly increased thymus, spleen, and bursa indices, as well as ND-HI antibody titers. SHEP enhanced CD4/CD8 T cell proportions in peripheral blood/intestine, and elevated IL-4, IFN-γ, TLR4, and CCR9 levels. SHEP also improved jejunal villi, increased villus height, crypt depth, and VH/CD ratio. 16S analysis revealed SHEP increased the abundances of Bacteroides, Parabacteroides and Alistipes, and optimized the F/B ratio and intestinal flora structure. Collectively, SHEP may enhance immunity and offer insights for the development of novel polysaccharide formulations. - Source: PubMed
Publication date: 2026/05/17
Lin YiZheng ZijieLin XianjieFan GuilanChen ChunyanQin TaoHe JinRen Zhe - IgA nephropathy (IgAN) is a mucosal immune-associated disease characterized by the overproduction of galactose-deficient IgA1 (Gd-IgA1) and formation of nephritogenic immune complexes. Epstein-Barr virus (EBV), which preferentially infects IgA B cells, has been implicated in IgAN pathogenesis, although its role remains unclear. Given mucosa involvement, we characterized breast milk B cells as available representatives of mucosal tissue to better understand the pathogenesis of IgAN. - Source: PubMed
Publication date: 2026/05/08
Zachova KaterinaCutkova AlicaKosztyu PetrOhyama YukakoTakahashi KazuoZadrazil JosefOrsag JiriPetejova NadezdaMestecky JiriRaska Milan - Selenium (Se) is known to improve gut health in animals, yet research on the effects of different dietary Se compounds on the intestinal health of broilers remains limited. Therefore, this study evaluated the effects of sodium selenite (SS), selenium-enriched yeast (SY), selenomethionine (SM), and nano-selenium (NS) on gut microbiota and their metabolites, intestinal antioxidant capacity, immune response, and gut morphology in broilers and investigated the potential molecular mechanisms by which Se influences intestinal function in broilers. A total of 360 1-d-old male yellow-feathered broilers with an average body weight of 37.00 ± 0.17 g were randomly assigned to five treatments, each comprising six replicates with 12 chicks per replicate. Broilers received either a basal diet or a basal diet supplemented with SS, SM, SY, and NS at 0.5 mg Se/kg for 56 d. Data were analyzed using one-way ANOVA with Tukey's post-hoc test for multi-group comparisons, and statistical significance was set at P < 0.05. Supplementation with SY increased ileal concentrations of secretory immunoglobulin A by 74.87% and interleukin-10 (IL-10) by 54.90%, enhanced ileal activities of total superoxide dismutase (T-SOD) by 123.55% and catalase by 197.20%, and elevated cecal acetate by 35.67% and total short-chain fatty acids (SCFAs) by 28.78%, as well as ileal ursodeoxycholic acid concentration by 154.05% (P < 0.05). Dietary SS elevated ileal IL-10 concentration by 44.72% and glutathione peroxidase activity by 93.74% while reducing tumor necrosis factor-alpha level by 26.46% (P < 0.05). Supplemental NS increased cecal concentrations of acetate by 45.56%, propionate by 85.94%, and total SCFAs by 39.68% (P < 0.05). Compared with the SS, SY supplementation improved jejunal total antioxidant capacity by 81.08% and ileal T-SOD activity by 84.22% (P < 0.05). Additionally, dietary Se supplementation increased the abundances of potentially beneficial bacteria, including Lactobacillus, Parabacteroides, Akkermansia, and UCG_005 (P < 0.05). Genes such as CCR9, CD28, MUC2, HTR6, KCNK5, and SLC9A3 were up-regulated, while GIP, SSTR2, SST1, and CRHR1 were down-regulated by SS or SY supplementation, indicating involvement in intestinal function. In summary, SS and SY improved intestinal antioxidant and immune functions in broilers, whereas SY and NS enhanced cecal SCFAs production. Moreover, Se supplementation modulated the cecal microbial community in broilers. - Source: PubMed
Chen JifaDai TianyueDeng JiayaoZhou JiayuPan YueXie HuiXu MingmingZhang HaiboZhang JiaxinQiu Guixiong