Goat Anti-Human CD344
- Known as:
- Goat Antibody toHuman CD344
- Catalog number:
- 129-10151
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Goat Anti-Human CD344
Related genes to: Goat Anti-Human CD344
- Gene:
- FZD4 NIH gene
- Name:
- frizzled class receptor 4
- Previous symbol:
- EVR1
- Synonyms:
- CD344
- Chromosome:
- 11q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2016-01-15
Related products to: Goat Anti-Human CD344
Related articles to: Goat Anti-Human CD344
- Inducing transplant tolerance to achieve long-term graft survival without immunosuppression remains a central objective in liver transplantation. - Source: PubMed
Publication date: 2026/04/17
Zhou LinZhao YangWang JingChen QingJia Ya-NanPan Li-ChaoWang Han-XuanYang Hong-WeiHe QiangLi Xian-LiangLang RenDu Guo-Sheng - Blood-brain barrier (BBB) disruption is a key pathological event following traumatic brain injury (TBI), yet its molecular and spatial characteristics remain incompletely understood. Here, we developed a dual dye-labeling system to assess the temporal and spatial dynamics of BBB permeability following controlled cortical impact (CCI) injury in (KO) and (WT) mice. By tracking Evans Blue Dye (EBD), sodium fluorescein (NaFl), and IgG deposition, we reveal distinct patterns of extravasation in the injured cortex and hippocampus. NaFl, a small-molecule tracer, continues to extravasate for 7 days post-injury, whereas EBD leakage diminishes after 4 days. Notably, EC-specific EphA4 KO mice exhibit a protective role in BBB integrity. To further investigate BBB regulation, we integrated spatial transcriptomics with dye quantification, revealing that EphA4 EC ablation upregulates key BBB-related genes ( ) and neuroprotective genes ( and ). Notably, Wnt signaling genes are upregulated in the KO cortex, and we demonstrate that inhibition of Frizzled-4 (FZD4)/Wnt attenuates BBB protection in KO mice. Importantly, direct pharmacological activation of Wnt signaling with the FZD4 agonist FZM1.8 reduces lesion volume and BBB disruption. Overall, these findings demonstrate the effectiveness of spatial transcriptomics and dual-dye labeling in uncovering region-specific transcriptional changes associated with BBB disruption following CCI injury and in assessing the influence of EphA4/Wnt signaling. Wnt signaling emerges as a promising pathway for BBB protection and repair following TBI, offering a potential strategy to mitigate secondary brain injury. - Source: PubMed
Publication date: 2026/04/09
de Jager CarolineJu JingCorbo MarcoPatel KaranTheus Michelle - As the most common microvascular complication of diabetes, diabetic retinopathy (DR) has become a leading cause of blindness among the global diabetic population. The pathogenesis of DR is not yet fully understood, and current clinical treatment options are limited and have suboptimal efficacy. A detailed investigation of the intercellular communication mechanisms during the progression of DR is of paramount importance. In this study, we first synthesized findings from various studies on classical pathways, including VEGF signaling, oxidative stress, inflammatory cascades, the polyol pathway, PKC signaling, and the Wnt/β-catenin pathway, with a focus on elucidating the cell-type specificity of each pathway and the interactions among them. Subsequently, we explored emerging mechanisms identified in recent years, such as the ethanolamine pathway, ANGPTL4, Lrg1, and Norrin-FZD4, to expand our understanding of the pathogenesis of DR. Through a systematic investigation of multiple pathways, we propose that the progression of DR is not driven by the effect of a single pathway but rather results from the dynamic interplay among these signaling networks. Additionally, we described recent advances in the clinical translation of related pathways, including multitarget therapeutic strategies and precision interventions mediated by pathway-specific biomarkers. This review aims to provide a comprehensive and integrative perspective on the mechanisms underlying DR, thereby establishing a theoretical foundation for experimental research and clinical translation. - Source: PubMed
Publication date: 2026/04/13
Wu ShenhaoGao Jing - Pathogenic variants in FZD4 have been implicated in the pathogenesis of familial exudative vitreoretinopathy (FEVR). We present a family with a novel FZD4 variant and provide functional evidence supporting its pathogenic relevance. - Source: PubMed
Publication date: 2026/04/14
Hung Jia-HorungNguyen Quan DongHsu Chao-KaiChang Yao-TsungChuang Woei-JerLin Pei-ChiChang Yu-ShanKuo Yi-ZihHwang SuanThng Zheng XianAkhavanrezayat AmirMobasserian AzadehMohammadi S SaeedYoo Woong-SunElaraby OsamaEl Feky DaliaGupta Ankur SudhirYang PaulWu Li-Wha - To report an adult case of familial exudative vitreoretinopathy (FEVR) initially resembling high myopia-associated retinal pathology. A single case was reviewed. An adult man with a history of high myopia and recurrent retinal detachments presented with temporal retinal atrophy, vessel straightening, and a large nasal retinal detachment with fibrosis and proliferative vitreoretinopathy (PVR) on dilated fundus examination. Fluorescein angiography (FA) demonstrated peripheral retinal nonperfusion. The patient underwent vitreoretinal surgery with adjunctive intravitreal methotrexate. Genetic testing identified a pathogenic heterozygous variant (p.Trp494*), confirming the diagnosis of FEVR. Although FEVR is a rare inherited retinal vascular disorder typically diagnosed in childhood, adult presentations may be misattributed to degenerative myopia, particularly in the presence of overlapping features such as staphylomas, macular atrophy, and retinal detachment. This case highlights the importance of FA and genetic testing in distinguishing inherited retinal disease from degenerative disease. Greater clinical awareness and access to molecular diagnostics may facilitate earlier recognition and improve the management of atypical retinal detachment in adults. - Source: PubMed
Publication date: 2026/04/03
Amuzie ChiomaYohannes GelilaFan JasonNegron Catherin IBerrocal Audina M