Mouse Anti-Human CD268
- Known as:
- Mouse Antibody toHuman CD268
- Catalog number:
- 129-10133
- Product Quantity:
- 25
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Mouse Anti-Human CD268
Related genes to: Mouse Anti-Human CD268
- Gene:
- TNFRSF13C NIH gene
- Name:
- TNF receptor superfamily member 13C
- Previous symbol:
- -
- Synonyms:
- BAFFR, CD268
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-22
- Date modifiied:
- 2019-04-23
Related products to: Mouse Anti-Human CD268
Related articles to: Mouse Anti-Human CD268
- Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of methotrexate-associated lymphoma arising in immune deficiency/dysregulation (MTX-associated IDD-DLBCL) among rheumatoid arthritis patients treated with MTX and is characterized by frequent spontaneous regression (SR) after MTX withdrawal. However, some patients do not achieve SR and have poor outcomes. Epstein-Barr virus (EBV) infection correlates with frequent SR but does not fully explain clinical heterogeneity. We investigated prognostic factors irrespective of EBV infection status. We analyzed 21 MTX-associated IDD-DLBCL cases applying the nCounter PanCancer Immune Profiling Panel and immunohistochemistry (IHC) to identify predictors of non-SR cases. Ten patients were classified as SR and 11 as non-SR. Gene expression profiling revealed higher expression of CD83, ICOSLG, IL21R, BCL6, CD40, PAX5, CXCR5, CD79A, DMBT1, and TNFRSF13C in non-SR cases. We therefore focused on CD83, which showed the highest fold change and the most significant P value among these markers. Although CD83 is reported to be a surface marker of mature dendritic cells, IHC analysis revealed that CD83 was more frequently expressed on tumor cells than on dendritic cells. High CD83 IHC positivity (≥15%) in tumor cells correlated with mRNA levels and predicted non-SR after MTX withdrawal. Multivariate analysis identified CD83 IHC high expression as an independent predictor of non-SR cases. High CD83 expression is an independent prognostic factor in MTX-associated IDD-DLBCL, and combined evaluation may refine risk stratification and guide clinical decisions. - Source: PubMed
Sawada KeisukeTakahashi TakumiFukumura YukiOnagi HirokoAshizawa KarinYamashita TakahisaYamamoto WataruTakayanagi NatsukoAdachi AkikoKashimura MakotoTabayashi TakayukiTamaru Jun-IchiHigashi MorihiroMomose Shuji - Systemic Lupus Erythematosus (SLE) and primary Sjögren's Disease (SjD) are autoimmune diseases characterized by the presence of autoantibodies that lead to damage in healthy tissues. The production of autoantibodies requires the activation and differentiation of B-lymphocytes into plasma cells. To achieve this effect, BAFF (B-lymphocyte activating factor), APRIL (A proliferation-inducing ligand), and their receptors are key factors. BAFF is a cytokine recognized by BAFF-R (BAFF receptor), which is increased and related to disease activity in both SLE and SjD patients. The H159Y mutation (rs61756766) in the gene encoding the BAFF-R, (Tumor Necrosis Factor Receptor Superfamily) has been shown in vitro to cause receptor hyperactivation via the NF-κB2 pathway. This study evaluated the frequency of this variant in a western Mexican population and its association with the risk of developing SLE and SjD. Genotypes of the H159Y (rs61756766) variant were determined by PCR-RFLP assay. sBAFF levels were measured by ELISA. The study included 300 SLE patients, 110 SjD patients, and 300 healthy subjects (HS). HS were in Hardy-Weinberg equilibrium. The data distribution was assessed using the Kolmogorov-Smirnov test. Group comparisons were conducted using the Chi-square test, Fisher's exact test, or the Mann-Whitney U test, as appropriate. A -value of <0.05 was considered statistically significant. In the Mexican population, allelic and genotypic distribution frequencies of the H159Y variant (rs61756766) were similar between SLE patients and HSs, while the variant was not found in SjD patients. SLE patients carrying the heterozygous CT genotype showed a trend toward higher soluble BAFF (sBAFF) levels than wild-type genotype patients. This variant does not confer risk to SLE or SjD in the Mexican population. However, the heterozygous genotype may be associated with high levels of sBAFF in SLE patients. - Source: PubMed
Publication date: 2026/01/10
Borunda-Calderón Itzel MaríaCorona-Angeles Jazz AlanEspinoza-García NoemíMarín-Rosales MiguelSalazar-Camarena Diana CelesteOregon-Romero EdithMorales-Zambrano Ramsés AlejandroPalafox-Sánchez Claudia Azucena - Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown. This study aimed to explore the longitudinal effects of RBC transfusion on plasma inflammatory and angiogenic proteins in chronically transfused patients with SCD. Plasma samples were collected from SCD patients treated with either exchange (N = 12) or top-up (N = 12) transfusion prior to transfusion and 1 h, 24-72 h, 1 and 2 weeks post-transfusion. Proximity Extension Assay technology was used to measure plasma values of 21 proteins at each of these timepoints. Exchange transfusion resulted in decreased values of proteins released during inflammasome activation (IL-1β, IL-18), B cell survival and activation (TNFRSF13B/TACI, TNFRSF13C/BAFFR, TNFSF13/APRIL), angiogenesis (ANGPT2, VEGFA, KDR, CXCL12), and neutrophil differentiation, recruitment and activation (G-CSF, G-CSFR, CXCL1, CXCL5, CXCL6), at 1 h post-transfusion, returning gradually to values comparable to pre-transfusion values during 2 weeks post-transfusion. In contrast, top-up transfusion resulted in increased values of EPO and ANGPT1. While exchange transfusion seems to reduce the activation of pro-inflammatory and pro-angiogenic pathways, top-up transfusion might result in reduced hypoxia and increased vascular stability as suggested by the increased values of EPO and ANGPT1. These results enhance our understanding of the effects of RBC transfusion on inflammatory and angiogenic pathways and suggest that exchange transfusion has a stronger effect on these pathways in SCD patients compared to top-up transfusion. - Source: PubMed
Publication date: 2026/01/06
de Ligt Lydian AThakoerdin Sanjay RZwolsman MaudStegemann GabyMatlung HankeKuijpers Taco WBiemond Bart JFijnvandraat Karinvan Bruggen RobinNur Erfan - : Sarcoidosis is a systemic granulomatous disease of unknown etiology. Pulmonary sarcoidosis with extrapulmonary lesions (EPL) confers poor prognoses. The transcriptomic features of peripheral blood mononuclear cells (PBMCs) could be crucial in sarcoidosis pathogenesis. However, the gene expression characteristics associated with EPL development remain unknown. : Bulk PBMCs were collected from 26 healthy controls and 14 patients with pulmonary sarcoidosis stratified into those with ( = 9) or without ( = 5) EPL. None of the participants were receiving immunosuppressive agents. PBMC transcriptomic analysis was conducted using RNA sequencing. : Principal component analysis (PCA) revealed a clear distinction between pulmonary sarcoidosis and healthy control groups, with 227 differentially expressed genes (88 upregulated, 139 downregulated), including upregulated (, , , , , , and ) and downregulated (, , , and ) genes in pulmonary sarcoidosis group. Enrichment analysis revealed upregulated immunological pathways related to granuloma formation in pulmonary sarcoidosis PBMCs, including T helper 17 and tumor necrosis factor-alpha signaling pathways, IL-1B, IL-6, and IL-17 production, and response to external stimuli. Furthermore, patients with and without EPL showed 206 differentially expressed genes (131 upregulated, 75 downregulated), including upregulated ( and ) and downregulated (, , and ) genes. Gene ontology (GO) analysis revealed that interleukin 6 (IL-6) and IL-23 production were upregulated in patients with EPL. : These findings elucidate the mechanisms underlying granuloma formation in sarcoidosis and demonstrate the differential transcriptomic features of PBMCs in patients with and without EPL. The upregulation of and may be related to EPL development and could serve as potential therapeutic targets for sarcoidosis. - Source: PubMed
Publication date: 2025/12/07
Murai YushiKawasaki TakeshiImamoto TakuroIshii DaisukeYoshioka KeiichiroHasegawa YoshinoriOhara OsamuTatsumi KoichiroSuzuki Takuji - Multiple myeloma treatment has experienced tremendous advances through chimeric antigen receptor (CAR) therapies directed to the B cell maturation antigen (BCMA), but remissions are usually transient. To mitigate the risk of BCMA immune escape, we aimed for a simultaneous targeting of BCMA together with the B cell-activating factor receptor (BAFF-R). Single-cell RNA sequencing discovered increased BAFF-R gene (TNFRSF13C) expression in relapsed and refractory multiple myeloma cases, and it emerged as prognostic marker for long-term complete responses. BAFF-R was expressed in plasma cells at earlier maturation stages compared with BCMA-positive plasma cell phenotypes. Bispecific BAFF-R/BCMA CARs endowed T cells with cytolytic efficacy against multiple myeloma cell lines and primary multiple myeloma cells. In vivo, the dual CAR compensated for BCMA downregulation when BAFF-R was expressed, preventing the evolution of antigen escape mutants that drive resistance to CAR T cell therapy. Our study proposes BAFF-R as a complementary target antigen suitable to eliminate malignant plasma cells with less advanced differentiation, lack of BCMA, and occurrence in dismal prognosis patients. - Source: PubMed
Publication date: 2025/12/09
Fiori AgneseZimmermann KarinLi AnnaWestermann JörgAnagnostopoulos IoannisMenzel LutzBunse MarioErdlei HenryJayarajan JeyanGrünschläger FlorianOrtiz-Aguirre Juan PabloHaas SimonTeßmann Uwe-JensFreitag JensRosenwald AndreasKwak LarryWang XiuliDong ZhenyuanCha SoungchulReiser JohnPeralta EigenValamehr BahramKrönke JanHöpken Uta ERehm Armin