Rat Anti-Human CD267
- Known as:
- Rat Antibody toHuman CD267
- Catalog number:
- 129-10132
- Product Quantity:
- 25
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Rat Anti-Human CD267
Related genes to: Rat Anti-Human CD267
- Gene:
- TNFRSF13B NIH gene
- Name:
- TNF receptor superfamily member 13B
- Previous symbol:
- -
- Synonyms:
- TACI, CD267, IGAD2
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-22
- Date modifiied:
- 2019-04-23
Related products to: Rat Anti-Human CD267
Related articles to: Rat Anti-Human CD267
- Background: The TNFRSF13B gene encodes TACI, a key regulator of B-cell survival and immune homeostasis. While variants in this gene are linked to immunodeficiency, their role in lymphoma development remains unclear. This study investigated whether the TNFRSF13B polymorphism rs4792800 (A>G) influences lymphoma risk. - Source: PubMed
Publication date: 2026/05/09
Nakano JuliaViet Nguyen HoangGiang Nguyen Hoang ThaoDac Do TungLong Hai Le HaThao Pham PhuongNagaya SatomiMorishita ErikoEspinoza J Luis - Common variable immunodeficiency disorder (CVID) is the most prevalent primary immunodeficiency in adults. Pathogenic mutations of the TNFRSF13B gene were identified in CVID patients and associated with autoimmunity and lymphoproliferation. A study on Swedish children unaffected by CVID has shown that rare variants in the TNFRSF13B gene increase the risk of asthma. To the best of our knowledge, asthma has not been reported in CVID patients with TNFRSF13B gene mutations. We described a patient suffering from asthma and CVID with a heterozygous mutation in the TNFRSF13B gene. According to our findings and previous studies, mutations in the TNFRSF13B gene seem to be possibly associated with the occurrence of asthma in CVID patients. - Source: PubMed
Publication date: 2026/02/01
Ranjbarnejad TayebehSalehi MansoorAbolhassani HassanSherkat RoyaSharifi Mohammadreza - Mycobacterium shinjukuense is a rare type of non-tuberculous mycobacterium (NTM) first reported in Japan. Reported cases of Mycobacterium shinjukuense pulmonary diseases are rare where hosts exhibited apparent risk factors for NTM infection. No consensus has been made on its treatment regimen. - Source: PubMed
Publication date: 2026/05/07
Gu SiweiWang ChunleiLu BinghuaiCui Xiaojing - The mature B cell compartment consists of follicular and marginal zone (MZ) B cells, which develop from transitional type 2 (T2) B cells. TACI, a member of the TNF receptor superfamily, is expressed on all mature B cells, with highest levels on MZ B cells and plasma cells. Previous studies reported that TACI is a negative regulator of B cell survival. However, this conclusion is confounded by elevated levels of BAFF, a cytokine that supports B cell survival, in TACI-deficient mice. We now show that TACI does not directly regulate B cell survival in mice but rather has a cell-intrinsic role in MZ B cell development. Loss of TACI leads to reduced MZ B cell numbers and an impaired T-independent antibody response. Mechanistically, we show that TACI is required for MZ B cell development from T2 B cell precursors via activation of the PI3K-AKT pathway and subsequent inhibition of the FOXO1 transcription factor. - Source: PubMed
Publication date: 2026/05/05
Luff Daisy HVanes LesleyBoeing StefanTybulewicz Victor L J - Inborn errors of immunity (IEIs) encompass a heterogeneous group of more than 550 genetic conditions with variable ages of onset. A significant proportion of IEI arises from genetic variants that may not yet be fully elucidated or recorded in existing genomic databases. Molecular diagnoses are achieved in approximately 15-35% of IEI cases, yet in only 9-20% of individuals with predominant antibody deficiencies, particularly in adult cohorts. We aimed to evaluate whole genome sequencing (WGS) diagnostic yield in adults suspected to have IEI. Clinical assessments of the patients were carried out at tertiary medical institutions in Timisoara and Bucharest, Romania. The study cohort included a consecutive series of 21 adult patients (aged 19-60 years) with IEI phenotype, who underwent genetic analysis, using WGS as the first diagnostic approach. A definitive molecular diagnosis was confirmed in only 9.5% (2/21) of the participants, in and genes. Variants of uncertain significance (VUS) were detected in three patients (13.6%) in , , genes. For about half of the cohort the onset of the disease was noted in childhood. WGS as a first-line diagnostic strategy in a cohort of adults with IEI yielded a low diagnostic rate. There were significant delays in genetic diagnosis, as half of the cohort experienced childhood-onset symptoms. Results suggest that adult IEI diagnosis remains challenging, necessitating functional studies and longitudinal re-evaluation of genomic data. - Source: PubMed
Publication date: 2026/04/10
Pantea Cristina-LoredanaBataneant MihaelaJurcut CiprianCochino AlexisIoan AndreeaMunteanu Catalin VasileZimbru Cristian GUrtila PatriciaChirita-Emandi Adela