Mouse Anti-Human CD258
- Known as:
- Mouse Antibody toHuman CD258
- Catalog number:
- 129-10127
- Product Quantity:
- 25
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Mouse Anti-Human CD258
Related genes to: Mouse Anti-Human CD258
- Gene:
- TNFSF14 NIH gene
- Name:
- TNF superfamily member 14
- Previous symbol:
- -
- Synonyms:
- LIGHT, LTg, HVEM-L, CD258
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2017-03-02
Related products to: Mouse Anti-Human CD258
Related articles to: Mouse Anti-Human CD258
- Chronic kidney disease (CKD) is a global public health burden characterized by irreversible renal function loss and progressive fibrosis. Non-invasive biomarkers reflecting intra-renal inflammation and early tubulointerstitial injury remain an unmet clinical need. We combined bioinformatics analysis with clinical validation to characterize two immune-related genes, TNFSF14 and CD40, in CKD progression. - Source: PubMed
Publication date: 2026/04/25
Gu XiamengLu YuqingSha HaonanZhang HanluChen HongxinQiu MengyueChen Xiaolan - Tumor necrosis factor superfamily 14 (TNFSF14) has been implicated in the pathogenesis of cardiovascular disease, including atrial fibrillation (AF). However, its role in predicting AF recurrence after catheter ablation (CA) remains unexplored. - Source: PubMed
Zhou DongtaoLiu FangLiu TongLi MengmengJiang ChenxiTang RiboWang WeiZhao XinLi ChangyiJia ChangqiNing ManFeng LiWen DanLin JingZhu HuiJiang YuexinGuo XueyuanLi SongnanJiang ChaoZhou NingSang CaihuaLong DeyongDu XinDong JianzengMa Changsheng - Women often experience greater disability after ischemic stroke than men, but the biological mechanisms underlying these differences remain unclear. Proteomic analysis may identify sex-specific molecular pathways that contribute to stroke rehabilitation and recovery. - Source: PubMed
Publication date: 2026/04/19
McLouth Christopher JHazelwood Hunter SFrank Jacqueline AHarp Jordan PDornbos DavidFraser Justin FPennypacker Keith R - Immune checkpoint blockade (ICB) targeting PD-1/PD-L1 axis has transformed breast cancer treatment, yet how therapy reshapes the tumor microenvironment (TME) through cell-cell communication (CCC) remains unclear. Existing CCC inference methods relying on correlations have difficulty distinguishing genuine signaling from confounded associations. Here, we present a causal inference framework that uses single-cell data and leverages treatment as an instrumental variable to identify genuine CCC networks, referred to as scIVCCC, which infers causal signal transduction across cell types. Applying scIVCCC to single-cell RNA-seq data from 31 breast cancer patients before and after anti-PD-1 therapy, we constructed causal CCC networks linking exhausted T cells to tumor-associated macrophages (TAMs). Our analysis reveals a dual role of T cell-macrophage crosstalk: CD4+ and CD8+ exhausted T cells drive anti-tumor M1-like TAMs activation via TNF-TNFRSF1A, TNFSF14-LTBR, and ICAM1-ITGAL/ITGB2. Conversely, they also induce immunosuppressive M2-like polarization through pathways such as TNF-TNFRSF1B (TNFR2), TNFSF14-TNFRSF14 (HVEM), and RPS19-C5AR1, which likely contribute to therapeutic resistance. Our causal modeling suggests that receptors within these networks, such as C5AR1, TNFR2, and CSF1R, may serve as potential candidates for combination therapies to enhance anti-PD-1 efficacy. Collectively, these findings demonstrate that scIVCCC offers a robust framework for dissecting treatment-induced CCC dynamics and prioritizing actionable targets for clinical translation. - Source: PubMed
Qiu AodongZhang HanRamsey Joseph DAndrews BryanSun BoyangRen ShuangxiaLu MengyaoZhang KunCooper Gregory FLu BinfengChen LujiaLu Xinghua - Chronic rhinosinusitis with nasal polyps is characterized by type 2 (T2) inflammation with elevated IL-5 and IL-13. Although group 2 innate lymphoid cells (ILC2s) drive T2 inflammation, their subset diversity and clinical relevance in nasal polyps (NPs) remain unclear. - Source: PubMed
Publication date: 2026/04/07
Kidoguchi MasanoriIwasaki NaruhitoPoposki Julie AOgasawara NorikoOka AikoKlingler Aiko ISuh LydiaAgrwal AditiBai JunqinStevens Whitney WPeters Anju TGrammer Leslie CWelch Kevin CSmith Stephanie SJohnson MicahRadwan AmrConley David BSchleimer Robert PKern Robert CTan Bruce KOkano MitsuhiroFujieda ShigeharuKato Atsushi