Goat Anti-Human CD196
- Known as:
- Goat Antibody toHuman CD196
- Catalog number:
- 129-10115
- Product Quantity:
- 100
- Category:
- Peptides
- Supplier:
- Ray Biotech
- Gene target:
- Goat Anti-Human CD196
Related genes to: Goat Anti-Human CD196
- Gene:
- CCR6 NIH gene
- Name:
- C-C motif chemokine receptor 6
- Previous symbol:
- STRL22
- Synonyms:
- CKR-L3, GPR-CY4, CMKBR6, GPR29, DRY-6, DCR2, BN-1, CD196
- Chromosome:
- 6q27
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-21
- Date modifiied:
- 2016-03-14
Related products to: Goat Anti-Human CD196
Related articles to: Goat Anti-Human CD196
- Colorectal adenomas represent precursor lesions in the adenoma-carcinoma sequence and are characterized by chronic low-grade inflammation. Chemokine CCL20/CCR6 signaling and metabolic hormone ghrelin have been implicated in colorectal tumorigenesis, while IgG glycosylation reflects systemic immune status. However, their interrelationship across different stages of adenoma dysplasia remains unclear. A total of 70 patients with histologically confirmed colorectal adenomas were stratified into low-grade (n = 36) and high-grade dysplasia (n = 34). Serum CCL20, CCR6, acylated and deacylated ghrelin concentrations were measured using enzyme immunoassay (ELISA), while IgG N-glycans were analyzed by hydrophilic interaction liquid chromatography-ultra performance liquid chromatography (HILIC-UPLC). Correlation analyses were performed to assess associations between inflammatory, metabolic, and glycomic parameters. No significant differences were observed between low- and high-grade dysplasia in circulating CCL20, CCR6, acylated or deacylated ghrelin, or IgG N-glycosylation profiles. A significant positive correlation between acylated and deacylated ghrelin was detected only in high-grade dysplasia. In low-grade dysplasia, CCL20 correlated significantly with deacylated ghrelin. Additional nominal associations between ghrelin, CCL20, and selected IgG glycan traits were identified but lost significance after Benjamini-Hochberg false discovery rate correction. These exploratory associations included bisecting glycans with deacylated ghrelin and CCL20 with GP20, GP21, GP1, and GP10. Although systemic inflammatory biomarkers, ghrelin isoforms, and IgG N-glycosylation did not differ between dysplasia grades, distinct correlation patterns suggest stage-specific relationships. The association between CCL20 and deacylated ghrelin in low-grade dysplasia and the strong correlation between ghrelin isoforms in high-grade dysplasia warrant further investigation. - Source: PubMed
Publication date: 2026/09/23
Hanžek MilenaTešija Kuna AndreaKifer DomagojKološnjaj IvonaGornik OlgaShapeski-Stojsavljević SanjaŠupraha Goreta Sandra - Asthma is a heterogeneous chronic inflammatory syndrome, with the T2-high endotype defined by robust type 2 immune responses and skewed T helper polarization. Although H3K9 acetylation (H3K9ac) is a key activating histone mark in T helper differentiation, its genome-wide promoter landscape in circulating immune cells of T2-high asthma remains uncharacterized. - Source: PubMed
Publication date: 2026/09/16
González DanielInfante AlexLópez-Kleine LilianaCeschin DaniloFernández-Sánchez María JoséCañas-Arboleda AlejandraZafra-Mejía CarlosRojas Adriana - The present study aimed to assess the CCR6 and CD244 expression on natural killer (NK) and natural killer T (NKT) cells, considering their different subsets and examining their associations with molecular cytogenetics and clinical outcomes in newly diagnosed adult acute myeloid leukemia (AML) patients. - Source: PubMed
Publication date: 2026/08/31
Zahran Asmaa MRayan AmalRefaat AhmedElsayh Ahmad Khalid IbrahimHussein Nour Y HSabet Marwa ASeif Eldin SalwaFergany AyaNarouz Merna WMahboob Yomna RAlbadry M Zahran Zeinab - Triple-negative breast cancer (TNBC) remains therapeutically challenging due to its aggressive metastatic potential, high recurrence rates, and lack of effective targeted therapies. Herein, we identified that SOX30 is significantly upregulated in TNBC and correlates with poor clinical prognosis. Functionally, SOX30 specifically drives TNBC metastasis and activates the TNFR2-mediated downstream NF-κB signaling cascade. Mass cytometry profiling of the tumor immune microenvironment revealed that SOX30 facilitates the recruitment of tumor-associated macrophages (TAMs) within pulmonary metastases, a finding corroborated by flow cytometric quantification. Mechanistically, downstream pathway analyses identified that SOX30 induces activation of the TNFR2-NF-κB axis and concurrently upregulates expression of the chemokine CCL20. Therapeutic intervention with CCL20 neutralizing antibodies or small-molecule CCR6 inhibitors effectively attenuated metastatic progression and abrogated TAM infiltration. Strikingly, combinatorial blockade using the TNFR2 inhibitor etanercept together with a CCR6 inhibitor exhibited superior anti-metastatic efficacy relative to control treatments. Collectively, our findings delineate a novel oncogenic SOX30-TNFR2-NF-κB-CCL20/CCR6 axis driving TNBC metastasis. These results establish SOX30 as a promising prognostic biomarker and a potential therapeutic target for anti-metastatic strategies in TNBC. - Source: PubMed
Publication date: 2026/09/09
Gao PingpingSun NaYang NingZhao TingtingFu RuiWu ZhenyuZhou YuqinTan XuanniZhang YiHan FeiQi Xiaowei - Few large-scale population-based studies have examined the association between COVID-19 and respiratory aspergillosis. Using nationwide data, we investigated whether SARS-CoV-2 infection increases respiratory aspergillosis incidence and whether COVID-19-associated aspergillosis affects COVID-19 severity. We also analyzed public COVID-19 transcriptomic datasets to assess effects on airway structural and immune cells. - Source: PubMed
Publication date: 2026/09/03
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