Goat Anti-Human CD196
- Known as:
- Goat Antibody toHuman CD196
- Catalog number:
- 129-10115
- Product Quantity:
- 100
- Category:
- Peptides
- Supplier:
- Ray Biotech
- Gene target:
- Goat Anti-Human CD196
Related genes to: Goat Anti-Human CD196
- Gene:
- CCR6 NIH gene
- Name:
- C-C motif chemokine receptor 6
- Previous symbol:
- STRL22
- Synonyms:
- CKR-L3, GPR-CY4, CMKBR6, GPR29, DRY-6, DCR2, BN-1, CD196
- Chromosome:
- 6q27
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-21
- Date modifiied:
- 2016-03-14
Related products to: Goat Anti-Human CD196
Related articles to: Goat Anti-Human CD196
- In colorectal cancer (CRC), mast cells (MCs) modulate tumor and immune cell interactions, influencing patient prognosis, though their role remains not fully elucidated. Our group previously uncovered that in the intestine MCs provide support for the effector functions of B cells, both in physiology and inflammation. - Source: PubMed
Publication date: 2026/04/21
Valeri VivianaMion FrancescaTonon SilviaMartinis EleonoraJachetti ElenaSulsenti RobertaCapezzali EleonoraBattista SerenaMangogna AlessandroMariuzzi LauraFontanot MarcoBelmonte BeatriceCancila ValeriaTripodo ClaudioMozzon MartaUzzau AlessandroFrossi BarbaraPucillo Carlo - Tuberculosis (TB) is a global epidemic that has threatened human health throughout recorded history. TB disease, caused by infection with () is heterogeneous between individuals, and clinical TB outcomes are impacted by genetic and environmental risk factors. -infected individuals must maintain a careful balance of cytokines and chemokines to eliminate or contain the bacteria without causing excessive inflammation and lung damage. The CC chemokine receptor 6 (CCR6) is expressed by several immune cell populations that are classically involved in the host response to . However, the precise functions of CCR6 in the context of TB disease pathogenesis remain underexplored. Here, we show that mice lacking the CCR6 receptor (CCR6 KO) failed to restrict bacterial burden in the lungs, leading to increased dissemination compared to wild-type C57BL/6J (B6) mice, with a more pronounced effect in the lungs of females. CCR6 KO mice also developed necrotic pulmonary lesions that were phenotypically distinct from B6 mice and produced elevated levels of pro-inflammatory cytokines and chemokines at the onset of adaptive immunity, particularly IL-17. Long-term infection experiments revealed that the absence of CCR6 enhances risk for mortality following infection, particularly in females. This study provides insights into the role of CCR6 during TB pathogenesis and establishes its importance in maintaining protective immunity against within the context of a genetically tractable mouse model that forms necrotic pulmonary granulomas. - Source: PubMed
Publication date: 2026/04/30
Harris Summer JAdefisayo Oyindamola OMeade Rachel KMoseman E AshleyPyle Charlie JSmith Clare M - Tumor-draining lymph nodes (LNs) are critical for initiating and maintaining antitumor immunity. However, systematic LN dissection (LND) remains the standard surgical procedure for lung cancer. This study aimed to investigate the immunological impact of tumor-draining LND on systemic T cell subsets. - Source: PubMed
Publication date: 2026/04/28
Kamigaichi AtsushiKagamu HiroshiMiyata YoshihiroMimae TakahiroTsubokawa NorifumiHirano KoichiOkada Morihito - The generation of transcript variants via alternative utilisation of transcription start sites (TSSs) is a pivotal regulatory mechanism in physiological and pathological states. Recent advancements in 5' single-cell RNA sequencing (scRNA-seq) have enabled TSS analysis at the single-cell level. However, RNA degradation leads to non-uniform read coverage, posing a critical challenge that significantly compromises accurate TSS quantification of scRNA-seq data. To address RNA degradation and improve TSS quantification, we develop scATS (single-cell alternative transcription start site) to estimate RNA degradation at both isoform and sample levels, and provide TSS quantification with or without degradation correction. Application of scATS reveals dynamic and context-dependent regulation of TSSs in haematopoiesis and disease, providing additional information on TSS isoforms that aids cell clustering at a finer resolution. Furthermore, we establish a machine-learning pipeline, lung cancer relevance score (LRS), to identify TSSs associated with lung cancer. We analyse TSS isoforms of CCR6, CCR2 and RTKN2 in lung cancer cell lines and confirm that isoforms highly transcribed in lung cancer promote cell proliferation and migration. Combined, we present a robust tool to accurately quantify TSS by accounting for RNA degradation, a common issue that confounds transcript quantification, and experimentally demonstrate the important roles of TSS-mediated gene regulation in tumourigenesis. - Source: PubMed
Publication date: 2026/04/28
Xu ZijieZhou ZhenTang ChaoZhang YatingMao BinZhang YimingChen LiZhang DanSong JunweiZheng XiuranLiu DefuWang HuiyingHe ZhifengChen TingfengLin Jing-WenChen Lu - This study aims to investigate the therapeutic potential of umbilical cord-derived mesenchymal stem cells (UCMSCs) for dry eye disease (DED) and elucidate the underlying mechanisms, with particular focus on the role of TSG-6 in modulating the pathogenic Th17/CCL20-CCR6 inflammatory axis. - Source: PubMed
Liang QiChen ZeyingLiu YaoyaoGuo RongjieZhang DiJiang JiaxuanWang ChenchenHu Kai