Mouse Anti-Human CD160, FITC-labeled
- Known as:
- Mouse Antibody toHuman CD160, fluorecein-labeled
- Catalog number:
- 129-10106
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Mouse Anti-Human CD160 FITC-labeled
Related genes to: Mouse Anti-Human CD160, FITC-labeled
- Gene:
- CD160 NIH gene
- Name:
- CD160 molecule
- Previous symbol:
- -
- Synonyms:
- BY55, NK1, NK28
- Chromosome:
- 1q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-02
- Date modifiied:
- 2016-10-05
Related products to: Mouse Anti-Human CD160, FITC-labeled
Related articles to: Mouse Anti-Human CD160, FITC-labeled
- CD244, expressed in the tumor microenvironment (TME), is associated with impaired function of natural killer (NK) and T cells; however, its role in diffuse large B-cell lymphoma (DLBCL) remains poorly understood. This study aimed to elucidate the immunological significance and regulatory mechanisms of CD244 in DLBCL. - Source: PubMed
Publication date: 2026/07/07
Yang YimingZeng BiyangYang HuiminLiu XinLi PeilinMai ChaoJian ShunhaiZhu Qiqi - Aberrant activation of SHH signaling contributes to the progression of multiple malignancies, with KIF7 functioning as a critical mediator that regulates signal transduction from SMO to GLI transcription factors. However, the specific role of KIF7 in ccRCC has not been fully elucidated. In this study, we investigated the expression pattern, prognostic significance, functional role, and potential mechanisms of KIF7 in ccRCC. Analysis of TCGA-KIRC data demonstrated that KIF7 expression was significantly elevated in tumor tissues compared with adjacent normal tissues. High KIF7 expression was strongly associated with advanced pathological stage and poor overall survival. IHC performed on commercial tissue microarrays further confirmed increased KIF7 protein levels in ccRCC samples. Functional experiments in the 786-O cell line revealed that KIF7 overexpression markedly enhanced cell proliferation. Mechanistically, KIF7 overexpression activated the Wnt/β-catenin signaling pathway and upregulated downstream cell cycle regulators, including c-Myc and c-Jun. KIF7 expression was positively correlated with infiltration of CD4 + T cells, macrophages, and neutrophils. Moreover, it showed significant positive associations with immune checkpoint molecules PDCD1 and CD160. GSCA/GDSC-based drug sensitivity prediction suggested that high KIF7 expression was associated with increased predicted sensitivity to docetaxel and bleomycin, whereas no significant association was observed for I-BET-762. In conclusion, KIF7 plays a tumor-promoting role in ccRCC by enhancing proliferation, activating Wnt/β-catenin signaling. Additionally, it was associated with shaping the immune microenvironment. These findings highlight KIF7 as a potential prognostic biomarker and therapeutic target in ccRCC. - Source: PubMed
Publication date: 2026/06/28
Wang YaoWang Xiao-MingHuo DaWang Shi-BoLiu Qian-YiPang JingShen TaoCui DiZhao Wen-JuanLuo Qing-FengLi NanChen Ai-QunCui Ju - LARC patients exhibit heterogeneity in their response to total neoadjuvant therapy (TNT). This study aims to screen and identify plasma biomarkers associated with treatment response to TNT in patients with locally advanced rectal cancer (LARC) to predict pathological complete response (pCR). - Source: PubMed
Publication date: 2026/06/08
Zhu ZonglinWen KaizhenZou BaoyiKang YanhuaChen JingqingZhu BinFan LipingHuang Haobo - In addition to well-established immune checkpoints (ICs), such as CTLA-4, PD-1, PD-L1, increasing attention is being directed toward next-generation ICs, including TIM-3, Gal-9, LAG-3, BTLA, HVEM, and CD160. Single nucleotide polymorphisms (SNPs) within IC-related genes may contribute to dysregulation of inhibitory pathways and impair anti-tumor immune responses. This study aimed to evaluate the association between selected IC gene variants and susceptibility to bladder cancer (BC). - Source: PubMed
Publication date: 2026/06/12
Andrzejczak AnnaKrajewski WojciechJaskuła EmiliaChorbińska JoannaTomkiewicz AnnaMałkiewicz BartoszSzydełko TomaszKarabon Lidia - Decidual natural killer (dNK) cells constitute approximately 70% of first-trimester decidual leukocytes and play critical roles in immune tolerance, angiogenesis, and trophoblast invasion. Single-cell RNA sequencing has revealed substantial heterogeneity within the dNK population, identifying three major subsets-dNK1, dNK2, and dNK3-with distinct transcriptomic profiles and predicted functions. dNK3 Characteristics: dNK3 cells are characterized by a CD160KLRB1CD103CD39 surface phenotype, T-bet-high/Eomes-intermediate transcription factor profile, and phenotypic resemblance to intraepithelial type 1 innate lymphoid cells (ieILC1). These cells demonstrate the highest effector capacity among dNK subsets, producing multiple cytokines (CCL5, XCL1, IFN-γ, GM-CSF) following stimulation. Predicted ligand-receptor interactions include CCL5-CCR1 with extravillous trophoblasts, XCL1-XCR1 with dendritic cells, and inhibitory axes through KLRB1-CLEC2D and TIGIT-PVR. Notably, dNK3 abundance undergoes dynamic changes across gestation and shows distinct spatial distribution within decidual compartments. - Source: PubMed
Publication date: 2026/05/13
Liu LidanZhang ZhaoHuang QianyiLiu BoWu Hongbo