Goat Anti-Human ABCB5
- Known as:
- Goat Antibody toHuman ABCB5
- Catalog number:
- 129-10010
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Goat Anti-Human ABCB5
Related genes to: Goat Anti-Human ABCB5
- Gene:
- ABCB5 NIH gene
- Name:
- ATP binding cassette subfamily B member 5
- Previous symbol:
- -
- Synonyms:
- EST422562, ABCB5beta, ABCB5alpha
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-05
Related products to: Goat Anti-Human ABCB5
Related articles to: Goat Anti-Human ABCB5
- Cell size has been associated with stem and progenitor cell states across multiple tissues, yet its regulation in the human corneal epithelium remains incompletely understood. This study aimed to characterize cell-size differences among limbal and corneal epithelial cell populations defined by the limbal stem cell (LSC) marker ABCB5 and the transit-amplifying cell (TAC) marker BCAM, and to investigate the molecular regulators of progenitor cell size. ABCB5-positive LSCs and BCAM-positive TACs were identified and isolated by flow cytometry, and the mean cell size was estimated using forward scatter (FSC). As a result, ABCB5-positive LSCs were significantly smaller than ABCB5-negative limbal epithelial cells, and BCAM-positive TACs exhibited a smaller cell size than BCAM-negative cells, particularly in the limbus. Immunofluorescence staining showed that Yes-associated protein 1 (YAP1) and BCAM were co-expressed in basal epithelial cells in the human limbus and cornea. Expression of the YAP1 transcriptional target gene CYR61 was elevated in BCAM-positive limbal cells. SiRNA-mediated knockdown of YAP1 or BCAM in cultured human limbal epithelial cells resulted in a significant increase in cell size. These findings identify small cell size as a characteristic feature of limbal BCAM-positive TACs and demonstrate that progenitor cell size is regulated by YAP1 and BCAM, highlighting an interaction between physical cell properties and progenitor function in the corneal epithelium. - Source: PubMed
Publication date: 2026/05/13
Suzuki KoseiSato ShinriFrank Markus HFrank Natasha YSasamoto Yuzuru - Building on the identification of ABCB5 as a marker of limbal stem cells (LSCs), this study examines CD63, a newly identified molecule co-expressed with ABCB5 in limbal epithelial cells, to define its role in maintaining corneal epithelial cell identity. - Source: PubMed
Sasamoto YuzuruSuzuki KoseiSato ShinriLee Catherine A AMartin GabrielleKsander Bruce RFrank Markus HFrank Natasha Y - This study evaluated the sublethal effects of pyraclostrobin (PY) (0.750-12.0 μg/L) and its underlying toxic mechanisms following 28 days of embryonic exposure. PY at ≥3.00 μg/L caused developmental toxicity, characterized by increased larval weight, reduced body length, and hepatic and renal impairment. Different PY concentrations similarly altered glucose, pyruvate, total cholesterol, triglyceride, and free fatty acid levels and the transcription of glycolipid metabolism-related genes. Whole-larvae metabolomics further showed that PY simultaneously disrupted ABC transporters, amino acid biosynthesis, and arginine and proline metabolism pathways. Moreover, strobilurins PY, azoxystrobin, and trifloxystrobin induced and transcription during zebrafish embryo-larvae development. Molecular docking revealed that strobilurins formed hydrophobic interactions with conserved Phe793 and Phe1043 residues in zebrafish ABCB5, whereas no conserved binding interactions were observed with ABCB4, suggesting substrate specificity between strobilurins and ABCB5. This study provides potential molecular targets of PY toxicity and highlights the need to assess its chronic ecological risks. - Source: PubMed
Publication date: 2026/03/07
Jiang JinhuaZhou WenjingFang NanHe HongmeiWang XiangyunLiu XinZhang Changpeng - Pediatric acute myeloid leukemia (AML) is a biologically distinct and aggressive malignancy with limited effective therapies. While emerging targeted agents, including menin, FLT3, and PRMT5 inhibitors, show promise, the transcriptomic effects and the role of extracellular matrix (ECM) regulators, such as nidogen-1 (NID1), in modulating therapeutic responses remain unclear. - Source: PubMed
Publication date: 2026/02/21
Daniel Muteb MuyeyAndwey Gradel Holel - Acylsugars are structurally diverse specialized metabolites secreted by glandular trichomes of Solanaceae plants and play a crucial role in defense against herbivores and pathogens. However, the mechanism underlying acylsugar secretion remains unclear. This study identifies and characterizes the plasma membrane ATP-binding cassette (ABC) transporter Sl-ABCB5 as a key component mediating acylsugar transport in trichome secretory cells of cultivated tomato (Solanum lycopersicum). Using CRISPR-Cas9-generated Sl-ABCB5 knockout mutants, we observed a dramatic reduction in trichome acylsugar accumulation, accompanied by increased susceptibility to western flower thrips (Frankliniella occidentalis). In vitro transport assays using membrane vesicles and protoplasts confirmed the ability of Sl-ABCB5 to transport acylsugars. Furthermore, virus-induced gene silencing and CRISPR-mediated knockout of ABCB5 orthologs in wild tomato (Solanumpennellii) and black nightshade (Solanum nigrum) demonstrated functional conservation of this transporter across Solanaceae species. Together, these findings reveal a conserved acylsugar transport mechanism and establish ABCB5 as a promising target for engineering enhanced insect resistance in Solanaceae crops. - Source: PubMed
Publication date: 2026/02/17
Lyu TaoHan LeiqinJin JianfengWang JianjingZhou HuiyanXu XiaoyanFeng ShanYu JingquanLast Robert LFan Pengxiang