Rat Anti-Mouse CD90 Thy-1.2
- Known as:
- Rat Antibody toMouse CD90 Thy-1.2
- Catalog number:
- 128-10061-2
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Rat Anti-Mouse CD90 Thy-1.2
Related genes to: Rat Anti-Mouse CD90 Thy-1.2
- Gene:
- THY1 NIH gene
- Name:
- Thy-1 cell surface antigen
- Previous symbol:
- -
- Synonyms:
- CD90
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-07-22
Related products to: Rat Anti-Mouse CD90 Thy-1.2
Related articles to: Rat Anti-Mouse CD90 Thy-1.2
- Traumatic brain injury (TBI) is a leading cause of mortality and morbidity and a major contributor to loss of working capacity in young adults. Current therapeutic options for TBI remain limited. This study aimed to assess the potential role and therapeutic value of ubiquitin-specific protease 18 (USP18) in TBI. - Source: PubMed
Publication date: 2026/09/29
Zhao YangyangLei PanLi YulongLiu ChengxiZhang YichenZeng ChuanSun YangyangChen XinhuiYuan RaoraoFan HengyiCheng ShiqiZhang Yan - Adoptive T cell transfer remains a fundamental technique for dissecting the molecular mechanisms governing T cell differentiation. A successful adoptive-transfer experiment typically relies on labor-intensive construction of specific congenic mouse strains to distinguish donor from host cells. This limitation may be addressed by a readily detectable surface reporter. Thy1 is a candidate, but it remains unclear whether it is a reliable reporter for monitoring adoptively transferred CD8 T cell differentiation because Thy1 is a functional protein involved in thymic development and cell activation. To address this question, we systematically evaluated the reliability, stability, and functional neutrality of Thy1.1 and Thy1.2, two Thy1 isoforms, as adoptive-transfer reporters during CD8 T cell differentiation . Our results show that endogenous Thy1 expression remains stable across the differentiation stages examined. In the experimental settings tested, exogenous Thy1 reporter expression did not measurably alter the assessed differentiation phenotypes or donor-cell recovery. We further constructed and validated a Thy1 reporter-based platform that captured phenotypes associated with both loss-of-function (shRNA) and gain-of-function (cDNA) modulation of the transcription factor T-bet. This system provides a practical option for congenic background-independent adoptive transfer and genetic studies of CD8 T cell differentiation. - Source: PubMed
Publication date: 2026/09/16
Liu ChunlongLiu ChunlingZhong JingYang XiaodiWang Dapeng - Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficits in social communication and interaction, and restricted interests or repetitive behaviors. ASD is approximately four times more prevalent in males than in females. In this study, we investigated whether sex hormones or sex chromosomes underlie the male bias in ASD susceptibility. - Source: PubMed
Publication date: 2026/09/07
Niu ChangranAn Juan JiMasterson Hannah VXu Baoji - Equine follicular aspirates obtained during ovum pick-up contain a heterogeneous mixture of mesenchymal stromal cells (MSC) and granulosa cells (GC). This study evaluates how selective isolation and expansion of MSC decrease GC populations. Follicular aspirates-derived cells were cultured up to passage four (P4) following a previously validated protocol. While freshly isolated follicular aspirates cells (FAC) displayed heterogeneous morphologies, early passages (P3-P4) showed a uniform, spindle-shaped phenotype compatible with MSC. Gene expression analysis by RT-qPCR revealed a marked upregulation of mesenchymal and stemness-associated genes (FN1, THY1, FGF2 and CD105) in P4-MSC compared with FAC, confirming enrichment of the MSC population. Conversely, GC-specific genes (FSHR, FOXL2 and CYP11A1) were significantly upregulated in FAC. These findings suggest that early passages efficiently promote selective MSC expansion while progressively eliminating GC. - Source: PubMed
Soriano-Campos María Del PradoMuñoz-García Carmen CristinaLuis-Calero MarcosDel Olmo-Ortiz MarianGallardo-Soler AlejandroMacías-García BeatrizGonzález-Fernández Lauro - Extracellular vesicles (EVs) are emerging as key mediators of disease-associated intercellular communication and as promising biomarker sources across many disease conditions, including joint disorders such as rheumatoid arthritis (RA) and osteoarthritis (OA). Molecular profiling of synovial tissue has uncovered disease-driving cellular states, but tissue biopsies are invasive and not routinely available. EVs in synovial fluid may offer a minimally invasive and complementary window into joint pathobiology. However, the molecular complexity of synovial fluid and the heterogeneity of EV populations have hindered the analysis of defined disease-relevant EV subsets. To address this challenge, we developed a refined size-exclusion chromatography-ultrafiltration (SEC-UF) workflow coupled to magnetic bead-based immunocapture for targeted enrichment of cell type-associated EV subpopulations from arthritic synovial fluid. As proof-of-concept, we targeted a stromal-associated EV population using CD90/THY1, a surface marker expressed by discrete synovial fibroblasts subsets implicated in arthritis pathobiology. In vitro validation using synovial fibroblast-derived EVs confirmed surface-accessible CD90 and demonstrated selective immunocapture of defined EV subpopulations. Application to patient-derived synovial fluid showed that SEC-UF pre-enrichment improves the robustness of CD90 EV recovery from this complex biofluid. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) profiling established broad EV-associated proteome coverage in synovial fluid (SF)-EV preparations and identified multiple proteins reflecting the inflamed arthritic synovial environment. Fraction-resolved proteomics enabled comparison of the CD90-immunocaptured SF-EV subset with the non-captured CD90/CD90 SF-EV pool. Differential proteomics and surfaceome-informed cell-of-origin analysis supported enrichment of stromal-associated surface markers in the CD90 fraction, whereas the non-captured SF-EV pool retained broader immune-associated and residual stromal EV inputs. Together, this fit-for-purpose workflow provides a strategy to resolve EV heterogeneity patient synovial fluid and supports future biomarker-oriented studies of defined subpopulations in arthritic diseases. - Source: PubMed
Kurth StefanieHanser EdveenaHäner-Massimi SimoneGiaglis StavrosGeier FlorianBurri DominikBuczak KatarzynaHeider UteWild StefanAcklin Yves PEgloff ChristianTiaden André NKyburz Diego