Rat Anti-Mouse CD44, Biotinylated
- Known as:
- Rat Antibody toMouse CD44, Biotinylated
- Catalog number:
- 128-10038-2
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- Ray Biotech
- Gene target:
- Rat Anti-Mouse CD44 Biotinylated
Related genes to: Rat Anti-Mouse CD44, Biotinylated
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: Rat Anti-Mouse CD44, Biotinylated
Related articles to: Rat Anti-Mouse CD44, Biotinylated
- Dermatoporosis involves age-related alterations in dermal structure and cellular function, including changes in collagen, elastin, and markers of skin senescence. Changes in skin biomarkers (collagen I, elastin, senescence-associated beta-galactosidase, CD44, and CD47) were assessed following the use of a novel moisturizer, GC (Galderma Laboratories, L.P., Fort Worth, TX), by subjects with mature, aging skin. - Source: PubMed
Ablon GlynisSchlesinger ToddEmesiani ChristineGarimella SindhuNguyen Thu QWidgerow AlanYork Jean PhilippeMeckfessel Matthew - Osteoarthritis (OA) progression is driven by chronic synovitis. However, the spatially organized macrophage subsets that sustain unresolved inflammation through evasion of apoptosis remain poorly characterized. The present study investigated the functional subsets and spatial niches of synovial macrophages that regulate apoptotic pathways in OA pathogenesis. Spatial transcriptomics, single‑cell RNA sequencing and apoptotic models were integrated to characterize macrophage interactions in the OA synovium. The anti‑apoptotic role of SPP1 macrophages was evaluated using adeno‑associated virus‑mediated macrophage‑targeted SPP1 knockdown and CCL3 neutralization in a mouse OA model. In addition, an virtual knockout model was employed to delineate SPP1‑mediated apoptotic regulatory networks and prioritize candidate compounds for future validation. Spatial multi‑omics revealed a TGF‑β‑enriched niche in which SPP1+ macrophages expand adjacent to senescent synovial fibroblasts. Distinct from their reported pro‑fibrotic roles, SPP1 macrophages directly suppressed apoptosis of inflammatory macrophages via the SPP1‑CD44 signaling axis, while recruiting additional myeloid cells through CCL3 secretion. , targeting SPP1 or neutralizing CCL3 effectively restored macrophage apoptosis, attenuated synovitis and cartilage degeneration. myeloid specific SPP1 knockout delineated apoptotic pathway perturbations. In conclusion, TGF‑β‑induced SPP1 macrophages establish an anti‑apoptotic inflammatory niche in OA synovium by directly inhibiting the apoptosis of inflammatory macrophages via SPP1 signaling and promoting myeloid recruitment. This spatially defined anti‑apoptotic circuit provides critical insight into persistent synovitis. - Source: PubMed
Publication date: 2026/10/02
Gong HanShen HaoZhang FengWang WeiZhou ShengWang LeiSun Yu - Early thymic progenitors (ETPs) retain the potential for alternative fates but commit to the T-cell lineage as they progress through the CD4CD8 double-negative (DN) thymocyte stages early in T-cell development. Current evidence suggests that T-lineage commitment occurs during the transition from the DN2a to DN2b stage, a process characterized by downregulation of c-KIT and CD44 expression. Moreover, Bcl11b activation in DN2a thymocytes closely coincides with T-lineage commitment. Despite this heterogeneity in Bcl11b-YFP expression within DN2a thymocytes, these cells have predominantly been studied as a single population due to the absence of cell-surface markers capable of resolving the corresponding substages. To define the T-lineage commitment transition process at higher resolution, we profiled c-KIT-expressing DN thymocytes in the mouse thymus using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). This revealed heterogeneity within DN2a thymocytes. We identified two subpopulations, which we termed DN2a-1 and DN2a-2, based on differences in CD34, CD90, and expression. DN2a-1 thymocytes co-expressed multipotency and T-lineage-associated markers, whereas DN2a-2 cells mainly displayed a transcriptional profile consistent with T-lineage commitment. Functional assays demonstrated that DN2a-1 thymocytes were more developmentally advanced than ETPs but remained multipotent, whereas DN2a-2 thymocytes were more mature and largely restricted to the T lineage. Furthermore, clonal lineage tracing indicated that these subsets were on a developmental continuum. Together, these findings reveal that the heterogeneous DN2a stage can be resolved further by CD90 expression into pre- and post-T lineage-restricted subsets. - Source: PubMed
Publication date: 2026/09/17
Parikh DhrutiGu KarenTomei SaraWeber Tom SNaik Shalin HChong Mark M W - Oral cancer represents a significant global health burden exacerbated by aggressive tumor behavior and inadequate therapeutic outcomes, collectively contributing to high morbidity and mortality rates. Current treatment modalities, including surgery, radiotherapy, and chemotherapy, are often limited by a lack of tumor specificity, poor drug permeability, systemic cytotoxicity, and the emergence of multidrug resistance. Consequently, there is a growing demand for biomaterial-based systems to effectively target oral cancer. Among natural polysaccharides, hyaluronic acid (HA) has emerged as a highly promising biomaterial owing to its biocompatibility, biodegradability, and low antigenicity. Notably, HA exhibits a high affinity for the CD44 receptor, which is markedly overexpressed in oral squamous cell carcinoma (OSCC) and plays a key role in tumor progression, metastasis, and chemoresistance in oral cancer. This review highlights recent advances in HA-based delivery systems for oral cancer, focusing on physicochemical properties, biological interactions, and therapeutic efficacy. Various HA-based delivery systems such as nanoparticles, hydrogels, nanofibers, and microneedles have been explored for oral cancer management. Additionally, preclinical, translational, chemistry, manufacturing, and control (CMC), and regulatory considerations are discussed to highlight the clinical relevance of HA-based delivery platforms. Further, the current challenges and future perspectives of HA-based drug delivery systems have been elaborated. - Source: PubMed
Publication date: 2026/10/01
Samadder BishalWagh SurajPandey GirirajFamta ParasKolipaka TejaswiniSikder AnupamaKhairnar PoojaPhatale VivekSingh Aashish KumarPandia ChandanSrivastava Saurabh - Skeletal muscle development in poultry involves the interplay between local myogenic programs and systemic metabolism, yet the inter-organ regulatory mechanisms linking these processes remain poorly understood. Here, we identified a structural variation (SV) in the IGF2BP1 locus-encoding an m6A reader protein-that promotes chicken muscle development through a liver-to-muscle regulatory axis. In a Gushi × Anka F₂ resource population, chickens carrying the L1 allele exhibited significantly increased muscle mass accompanied by elevated serum cholesterol, triglycerides, and VLDL, indicating enhanced hepatic metabolic output. Integrative multi-omics analyses combining liver transcriptomics, co-immunoprecipitation mass spectrometry (CoIP-MS), and RNA immunoprecipitation sequencing (RIP-seq) revealed that IGF2BP1 interacts with proteins enriched in ATP synthesis and lipid metabolism while directly binding CD44 mRNA. Notably, strong positive correlations between serum lipid levels and muscle CD44 expression (r > 0.90, P < 0.01) supported the in vivo relevance of this hepatic-muscular cascade. Mechanistically, IGF2BP1 stabilized CD44 transcripts in an m6A-dependent manner, as validated by methylated RNA immunoprecipitation-qPCR (meRIP-qPCR), mRNA decay assays, and dual-luciferase reporter experiments. In primary myoblasts, CD44 overexpression accelerated cell cycle progression and enhanced migratory capacity by 1.84-fold, whereas CD44 knockdown suppressed both proliferation and migration. These findings define a novel m6A-dependent IGF2BP1-CD44 axis that bridges hepatic metabolism with myogenic programs, providing molecular targets for marker-assisted selection to improve meat production in poultry. - Source: PubMed
Publication date: 2026/09/28
Wanying XieYixiang TianXintao JiaWenping DuChaoqun GaoYanru LeiLan YangKejun WangGuirong SunXiangtao KangWenting Li