Recombinant Human AgRP, 2 ug...
- Known as:
- Recombinant Human AgRP, 2 ug...
- Catalog number:
- PR15048-02
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- Recombinant Human AgRP 2 ...
Related genes to: Recombinant Human AgRP, 2 ug...
- Gene:
- AGRP NIH gene
- Name:
- agouti related neuropeptide
- Previous symbol:
- -
- Synonyms:
- Agrt, ART, ASIP2
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-22
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human AgRP, 2 ug...
Related articles to: Recombinant Human AgRP, 2 ug...
- To explore whether hydroxy-alpha-sanshool (HAS) prevents obesity by modulating appetite and the gut microbiome, an obesity model was established using mice fed a high-fat diet. The food intake, body mass, feed efficiency and organ index of the mice were recorded, and the serum levels of GLP-1 and PYY were measured. The mRNA and protein expression of appetite-related genes in the small intestine and brain tissue were detected by real-time quantitative PCR and Western blotting, and the intestinal flora was analyzed by 16S rRNA gene sequencing. The results revealed that the body weight, food intake and feed efficiency of the mice were significantly reduced (4.28%, 14.46%, and 25.33%, respectively) and that the levels of GLP-1 and PYY were significantly increased ( < 0.05) (9.11% and 5.49%, respectively) by the HAS intervention. The relative mRNA expression of NPY and AGRP in the small intestine decreased significantly (39.62%, 21.95%) ( < 0.05); the relative mRNA levels of CART, GLP-1R, NPY2R and GLP-1 in the brain tissue increased significantly; and those of NPY and AGRP decreased significantly ( < 0.05). The protein expression of POMC and GLP-1 increased significantly ( < 0.05), whereas the protein expression of NPY and AGRP decreased significantly ( < 0.05). The diversity of intestinal flora in the cecal contents and the relative abundance of probiotics among the dominant flora increased. In conclusion, HAS could modulate the expression of appetite-related factors and the composition of intestinal microbiota in mice fed with a high-fat diet by regulating food intake and maintaining energy homeostasis, which is consistent with the involvement of the gut-brain axis in this regulatory mechanism. - Source: PubMed
Publication date: 2026/06/01
Luo TiantingZhu YupingXu FangyanXie JiaoChen HuifangQin LikangRen Tingyuan - Chemotherapy-induced anorexia cachexia (CAC) is a common adverse effect of cancer treatment and is associated with poor prognosis and reduced treatment tolerance. Despite its clinical relevance, effective interventions targeting central mechanisms of CAC remain limited. This study investigated whether aerobic exercise modulates hypothalamic appetite regulation and inflammatory signaling in a mouse model of cisplatin-induced CAC. - Source: PubMed
Publication date: 2026/06/06
Park Se HwanKo Jeong RimYoon Chang ShinPark Nam MiGarcia Maria Victoria Faith VKim Hyung KyuHan Jin - The precise regulation of energy homeostasis is essential for sustainable poultry production. Dysregulation of the avian gut-brain axis (GBA) contributes to metabolic disorders such as ascites and sudden death syndrome, impaired feed efficiency, and welfare problems in high-yield broilers. The avian GBA is a specialized bidirectional network that integrates hormonal, neural, and microbial signals to match feeding behavior with acute nutrient availability and long-term metabolic demands. Unique avian traits include a simplified gustatory system, lack of a functional T1R2 sweet receptor, a divergent leptin system, and distinct microbiota composition; these traits necessitate a species-specific framework for appetite control. This narrative review synthesizes current knowledge on how peripheral signals from the gastrointestinal tract, pancreas, liver, adipose tissue, and microbiota are encoded and conveyed to central command centers to regulate feed intake in poultry. We first outline nutrient sensing and gut-derived hormones with complex or divergent actions in birds (ghrelin, peptide YY, somatostatin), then summarize canonical satiety peptides (cholecystokinin, proglucagon-derived peptides, amylin, bombesin-like peptides, and neuromedin U) and long-term metabolic cues (leptin, insulin, insulin-like growth factors, liver-expressed antimicrobial peptide-2). At the central level, we describe how arcuate neuropeptide Y/agouti-related peptide (NPY/AgRP) and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons, downstream hypothalamic nuclei, and brainstem relays integrate these inputs into a dynamic balance between opposing orexigenic and anorexigenic neurochemical effector pathways. Finally, we link these mechanistic insights to potential practical strategies for improving feed conversion, reducing metabolic disease, and enhancing resilience to environmental stressors. These strategies include dietary and microbiota-targeted interventions, receptor-level modulation, and the use of divergent genetic lines. - Source: PubMed
Publication date: 2026/06/01
Mahdavi KimiaZendehdel MortezaGhashghaei ElhamLin Hai - Animal models of cancer anorexia/cachexia are instrumental in investigating the underlying mechanisms. However, even among reports on the same cancer model, experimental procedures can vary, hindering the comparisons between studies. - Source: PubMed
Publication date: 2026/05/19
Licursi MariaMorden CalebRiwa Deogratias GBriggs HaleyHirasawa KensukeHirasawa Michiru - AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVH neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVH neurons causes persistent hypophagia. This PVH-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation. - Source: PubMed
Publication date: 2026/06/03
Walker Samuel JLowenstein Elijah DDouglass Amelia MThomas Callum M PMadara Joseph CKucukdereli HakanBarbosa-Meillon Eunice ATao JenkangResch Jon MLowell Bradford B