Recombinant Rat, PDGF-BB, CF, 50 ug.
- Known as:
- Recombinant Rat, PDGF-BB, CF, 50 ug.
- Catalog number:
- PR15027CF-50
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- Recombinant Rat PDGF- 50 .
Related genes to: Recombinant Rat, PDGF-BB, CF, 50 ug.
- Gene:
- PDGFA NIH gene
- Name:
- platelet derived growth factor subunit A
- Previous symbol:
- -
- Synonyms:
- PDGF1, PDGF-A
- Chromosome:
- 7p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- PDGFRA NIH gene
- Name:
- platelet derived growth factor receptor alpha
- Previous symbol:
- -
- Synonyms:
- CD140a, PDGFR2, GAS9
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2019-04-23
- Gene:
- PDGFRB NIH gene
- Name:
- platelet derived growth factor receptor beta
- Previous symbol:
- PDGFR
- Synonyms:
- JTK12, CD140b, PDGFR1
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Rat, PDGF-BB, CF, 50 ug.
Related articles to: Recombinant Rat, PDGF-BB, CF, 50 ug.
- ObjectiveVisceral adipose tissue (VAT) produces several adipokines; however, VAT adipocytes' gene expression has not been related with cardio-metabolic components. The present study aimed to explore associations between gene expression in human primary VAT adipocytes' and cardio-metabolic components in subjects who live with Metabolically Unhealthy Obesity (MUO) compared with subjects who live with Metabolically Healthy Obesity (MHO).MethodsCross-sectional study of patients who live with obesity, who underwent bariatric/metabolic surgery.ResultsForty-five patients (18 MHO and 27 MUO) aged 44 years, main co-morbidities Diabetes and Hypertension, were analyzed. MUO showed younger age and higher cardio-metabolic risk, as well as larger adipocyte´s sizes. Primary cultured adipocytes were isolated from trans-surgical VAT sample, then cDNA was analyzed for the expression of 92 genes, further distributed as MUO MHO and clustered according to their linkage with cardio-metabolic components. Higher expression of genes like EDN1, IL-6, ADIPOQ, GSTA2, TGFβ, WNT3A, KDR, MAPK3, vWF (p<0.04); as well as reduced NOS2, PDGFA, HAMP and RARRES2 (p<0.01) were observed across clusters of hyperglycemia, hypertension, dyslipidaemia, and central obesity, broadly implicating pathways related to inflammation, oxidative stress, endothelial dysfunction, insulin resistance, and vascular regulation.ConclusionFindings from the present exploratory analysis show that cardio-metabolic risk is associated to VAT adipocytes' gene expression; particularly those genes related to oxidative stress, insulin resistance, inflammation, endothelial dysfunction, athero-thrombosis, and lower vasodilation. Further longitudinal and mechanistic studies are required to clarify the directionality and clinical significance of these associations. - Source: PubMed
Publication date: 2026/07/04
Suárez-Cuenca Juan AntonioHernández-Patricio AlejandroVera-Gómez EduardoGutiérrez-Buendía Juan ArielRuíz-Hernández Atzín Suáde la Vega-Moreno KarenDe la Peña-Sosa GustavoMontoya-Ramírez JesúsMelchor-López AlbertoDiaz-Aranda María AngélicaBernal-Figueroa YareniMartínez-Torres Gustavo IvánGutiérrez-Salinas JoséAlcaráz-Estrada Sofía LizethGarcía SilviaPineda-Juárez Juan AntonioToledo-Lozano Christian GabrielRamos-Vázquez Dulce CeciliaDelaflor-Wagner Christian AlejandroTéllez-González Mario AntonioMondragón-Terán PaulZermeño-Ugalde Pablo - Tumor budding (TB), defined as single tumor cells or small clusters (≤4 cells) at the invasive front, is a strong adverse prognostic feature in oral squamous cell carcinoma (OSCC). However, the stromal regulators and molecular mechanisms that drive TB remain unclear. Here, we developed a tumor-budding organoid (TBO) model that faithfully recapitulates the OSCC tumor-stroma interface and budding dynamics. By integrating this model with single-cell RNA sequencing (scRNA-seq), in situ RNA sequencing (isRNA-seq), and functional perturbations, we identify platelet-derived growth factor receptor alpha/integrin α2 (PDGFRα/integrin α2) cancer-associated fibroblasts (CAFs) as the key stromal subset promoting OSCC budding. OSCC cells recruit PDGFRα CAFs through PDGFA/PDGFRα signaling. These CAFs engage OSCC cells through two complementary crosstalk pathways: (1) heterotypic E-cadherin/integrin α2β1 adhesion that transmits biomechanical cues to activate YAP signaling and induce epithelial-mesenchymal transition (EMT)-like programs; and (2) tunneling nanotube (TNT)-mediated mitochondrial transfer that enhances oxidative phosphorylation (OXPHOS) and bioenergetic supply in budding cells. Targeted inhibition of TNT-mediated mitochondrial transfer markedly suppresses TB in TBO and xenograft models. Together, our results reveal a mechano-metabolic symbiosis between PDGFRα/integrin α2 CAFs and OSCC cells that drives TB and provides actionable targets to block this aggressive metastatic precursor. - Source: PubMed
Publication date: 2026/06/30
Liu YufangLi JiaoLiu JuanDong QiZhang HaoyangWang YanjinLi HuibingGuan YeCao LeiZhang ManqingGuo FangningLiu XueYang ZhenLu MengmengLiu HuiZhong LaipingJi TongLiu Tingjiao - Triple-negative breast cancer (TNBC) remains lethal due to paucity of targetable markers. MicroRNAs are involved in TNBC pathogenesis; however, their clinical translation in TNBC remain limited. We evaluated miR-6809 and miR-4753 expression in TNBC tissues, their potential as diagnostic biomarkers, and their correlations with tumor-related data. - Source: PubMed
Publication date: 2026/06/19
Taha MohamedMekhael EmadAbd-Al Aziz Ahmed - The function of platelet-derived growth factor (PDGF) in the prognosis of head and neck squamous cell carcinoma (HNSCC) remains unknown. This study aims to investigate the role of PDGF in the prognosis of HNSCC and explore its potential mechanisms. - Source: PubMed
Publication date: 2026/04/26
Li YingZhou Shengfei - Solamargine is a natural compound derived from the traditional Chinese medicinal plant , and exhibits a variety of biological activities, including anti-inflammatory, antimalarial, pro-apoptotic, analgesic, and antitumor effects. However, the role of solamargine in liver fibrosis remains unclear. This study aims to investigate the anti-fibrotic effects and potential mechanisms of solamargine using human hepatic stellate cells (LX-2 cells) and a carbon tetrachloride (CCl)-induced mouse model of liver fibrosis. - Source: PubMed
Huang RuihuaAli Alshami Mohammed Abdulaziz YahyaZhu XiaoyunHu Changping