TRPV3, control peptide, goat, 50 ug.
- Known as:
- TRPV3, reference short protein sequence, caprine, 50 ug.
- Catalog number:
- P15180
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- TRPV3 control peptide goat 50 .
Related genes to: TRPV3, control peptide, goat, 50 ug.
- Gene:
- TRPV3 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 3
- Previous symbol:
- -
- Synonyms:
- VRL3
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-05
- Date modifiied:
- 2016-10-05
Related products to: TRPV3, control peptide, goat, 50 ug.
Related articles to: TRPV3, control peptide, goat, 50 ug.
- Transient receptor potential (TRP) cation channel subfamily V member 1 (TRPV1) is predominantly expressed in sensory neurons and activated by nociceptive stimuli, including capsaicin, heat, and acidic conditions. Recent research has highlighted the role of TRPV1 in the pathophysiology of dry eye disease (DED). This study evaluated the antagonistic activity and TRP channel selectivity of motugivatrep, a novel TRPV1 antagonist. The inhibitory effects of motugivatrep were assessed in cells expressing various TRP channels as well as in rat dorsal root ganglion (DRG) cells, with agonist-induced intracellular Ca influx used as an indicator. Off-target effects were evaluated using comprehensive Cerep pharmacology profiling, which included radiolabeled ligand-binding assays for major ion channels, receptors, and enzyme assays. Motugivatrep exhibited pronounced inhibition of capsaicin-stimulated TRPV1 across multiple species, with IC values ranging from 0.46 to 2.1 nM. Furthermore, although motugivatrep exhibited weak inhibition of human TRPV4, it had no significant effects on TRPV3, TRPA1, or TRPM8. Additionally, motugivatrep suppressed capsaicin-induced intracellular Ca influx in DRG cells (IC = 2.8 nM). Off-target profiling revealed minimal binding to 5-HT and 5-HT receptors. Overall, these findings indicate that motugivatrep is a potent and highly selective TRPV1 antagonist, supporting its potential as a therapeutic candidate for disorders associated with TRPV1 activation, such as DED. - Source: PubMed
Uemura TomokaUchida HideharuHigashi ChikaAmano Ken-IchiKanda Atsuhiro - To study the cause of recurrent endometritis, which recurred after standard antibiotic therapy, we report the case of a 40-year-old woman with a history of recurrent pregnancy, preterm birth, and CE. The endometritis recurred following a standard antibiotic regimen. - Source: PubMed
Publication date: 2026/09/12
Kuo Pao-LinHsu Chao-KaiLin Yu-ChenTsai Pei-JaneChu Shih-KaiChen Kuan-Ru - Palmoplantar keratoderma (PPK) represents a diagnostically challenging group of genodermatoses due to its extensive genetic heterogeneity. Although multiple causative genes have been identified, the clinical utility of these discoveries remains limited, because few studies directly compare how distinct molecular mechanisms translate into divergent clinical phenotypes. - Source: PubMed
Publication date: 2026/09/05
Liu Jia-WeiHabulieti XiaerbatiQian Yue-TongMa XiaoHan YangyangMa Dong-Lai - An adequate supply of protein and minerals, particularly nitrogen (N) and calcium (Ca), is essential for ruminant growth and metabolic function. The rumen and salivary glands are crucial for nutrient and electrolyte homoeostasis via specialised transport proteins. Dietary reductions in N and Ca may elicit adaptive molecular and physiological responses, but their effects on epithelial transport are still not entirely understood. This study investigated the effects of dietary N and Ca reductions on ruminal and salivary fluid composition and the mRNA expression of Ca-, phosphate (Pi)-, and urea-transporting proteins in the ruminal epithelium and salivary glands of young goats. Goats received diets with reduced N, reduced Ca, or combined N and Ca reduction. Ruminal and abomasal fluids, saliva, and tissue samples were analysed for mineral concentrations, urea, and short-chain fatty acids (SCFAs). mRNA expression of transporters, including CASR, TRPC3, TRPV3, PMCA, NCX1, UTB, SLC4A4, ATP1B1 (Na/K-ATPase β-subunit), AQP5, NaPi IIb, and PiT1 was quantified using qPCR. Dietary N reduction decreased ruminal and salivary urea concentrations, reduced mRNA expression of SLC4A4, AQP5, and NaPi IIb in salivary glands, and lowered ruminal SCFA concentrations, indicating impaired microbial fermentation. The dietary Ca reduction increased salivary Pi and induced upregulation of AQP5, ATP1B1, and PiT1. In the ruminal epithelium, N reduction increased PMCA and UTB expression, whereas Ca reduction had only minor effects on Ca transporters. Ruminal Pi and Ca concentrations remained stable, reflecting strong stabilisation of mineral concentrations in the ruminal environment, whereas abomasal fluid showed greater sensitivity to dietary changes. These results indicate tissue-specific transcriptional and compositional responses of ruminant epithelia to dietary N and Ca reduction. N reduction primarily affects the expression of genes related to nutrient and solute transport, whereas Ca reduction is associated with selective transcriptional changes in mineral-related transporters. These results provide evidence for adaptive epithelial responses to nutritional variation, although functional consequences at the protein or transport level require further investigation. - Source: PubMed
Publication date: 2026/09/08
Egler Christopher-YannikHeidelberg MadlinBurmester MarionHustedt KarinSchnepel NadineMuscher-Banse Alexandra S - Atopic dermatitis (AD) is characterized by pruritus, epidermal hyperplasia, and lichenification that significantly impairs quality of life. Nemolizumab, an anti-IL-31Rα monoclonal antibody, is approved for treating moderate-to-severe AD in patients aged > 12 years. This study investigated nemolizumab's molecular mechanisms using patient samples from the ARCADIA 1 (NCT03985943) and 2 (NCT03989349) trials. - Source: PubMed
Publication date: 2026/09/04
Liu DanielDuca Ester DelDelaleu NicolasLau MeganPulsinelli Julianade Rosa Joel CorreaBar JonathanEstrada YerielGudjonsson JohannJulia ValerieGuttman-Yassky Emma