TRPV3, control peptide, goat, 50 ug.
- Known as:
- TRPV3, reference short protein sequence, caprine, 50 ug.
- Catalog number:
- P15180
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- TRPV3 control peptide goat 50 .
Related genes to: TRPV3, control peptide, goat, 50 ug.
- Gene:
- TRPV3 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 3
- Previous symbol:
- -
- Synonyms:
- VRL3
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-05
- Date modifiied:
- 2016-10-05
Related products to: TRPV3, control peptide, goat, 50 ug.
Related articles to: TRPV3, control peptide, goat, 50 ug.
- An adequate supply of protein and minerals, particularly nitrogen (N) and calcium (Ca), is essential for ruminant growth and metabolic function. The rumen and salivary glands are crucial for nutrient and electrolyte homoeostasis via specialised transport proteins. Dietary reductions in N and Ca may elicit adaptive molecular and physiological responses, but their effects on epithelial transport are still not entirely understood. This study investigated the effects of dietary N and Ca reductions on ruminal and salivary fluid composition and the mRNA expression of Ca-, phosphate (Pi)-, and urea-transporting proteins in the ruminal epithelium and salivary glands of young goats. Goats received diets with reduced N, reduced Ca, or combined N and Ca reduction. Ruminal and abomasal fluids, saliva, and tissue samples were analysed for mineral concentrations, urea, and short-chain fatty acids (SCFAs). mRNA expression of transporters, including CASR, TRPC3, TRPV3, PMCA, NCX1, UTB, SLC4A4, ATP1B1 (Na/K-ATPase β-subunit), AQP5, NaPi IIb, and PiT1 was quantified using qPCR. Dietary N reduction decreased ruminal and salivary urea concentrations, reduced mRNA expression of SLC4A4, AQP5, and NaPi IIb in salivary glands, and lowered ruminal SCFA concentrations, indicating impaired microbial fermentation. The dietary Ca reduction increased salivary Pi and induced upregulation of AQP5, ATP1B1, and PiT1. In the ruminal epithelium, N reduction increased PMCA and UTB expression, whereas Ca reduction had only minor effects on Ca transporters. Ruminal Pi and Ca concentrations remained stable, reflecting strong stabilisation of mineral concentrations in the ruminal environment, whereas abomasal fluid showed greater sensitivity to dietary changes. These results indicate tissue-specific transcriptional and compositional responses of ruminant epithelia to dietary N and Ca reduction. N reduction primarily affects the expression of genes related to nutrient and solute transport, whereas Ca reduction is associated with selective transcriptional changes in mineral-related transporters. These results provide evidence for adaptive epithelial responses to nutritional variation, although functional consequences at the protein or transport level require further investigation. - Source: PubMed
Publication date: 2026/09/08
Egler Christopher-YannikHeidelberg MadlinBurmester MarionHustedt KarinSchnepel NadineMuscher-Banse Alexandra S - Atopic dermatitis (AD) is characterized by pruritus, epidermal hyperplasia, and lichenification that significantly impairs quality of life. Nemolizumab, an anti-IL-31Rα monoclonal antibody, is approved for treating moderate-to-severe AD in patients aged > 12 years. This study investigated nemolizumab's molecular mechanisms using patient samples from the ARCADIA 1 (NCT03985943) and 2 (NCT03989349) trials. - Source: PubMed
Publication date: 2026/09/04
Liu DanielDuca Ester DelDelaleu NicolasLau MeganPulsinelli Julianade Rosa Joel CorreaBar JonathanEstrada YerielGudjonsson JohannJulia ValerieGuttman-Yassky Emma - The ability to sense environmental temperature is fundamental to animal survival, physiological homeostasis, and adaptation to changing environments. Animals rely on temperature-responsive molecules to detect changes in environmental and internal temperatures to maintain their thermal homeostasis. Among these molecules, the best-characterized group belongs to the transient receptor potential (TRP) channel superfamily, commonly referred to as thermoTRPs. ThermoTRPs have been extensively studied and are well established as thermoreceptors. In recent years, cryo-electron microscopy (cryo-EM) has enabled the structural characterization of numerous thermoTRP channels in their closed-state and agonist-induced open state, providing unprecedented insights into their architecture and gating mechanisms. Despite these advances, the molecular mechanisms by which thermoTRPs undergo temperature-induced activation remain poorly understood. This review focuses on six pioneering cryo-EM studies reporting temperature-induced open structures to summarize current structural evidence and discuss potential mechanisms by which temperature drives channel opening in thermoTRPs. - Source: PubMed
Publication date: 2026/08/17
Ni Lina - Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel highly expressed in the skin and intestine. While its roles in itch and skin inflammation are established, the physiological role of TRPV3 in the intestine remains relatively poorly understood. Topical application of a TRPV3 inhibitor, KM-001, has entered phase I clinical trials for the treatment of pruritus; however, its poor metabolic stability limits broader therapeutic application. Here, we show that the KM-001-derivative Colivin has comparable TRPV3-blocking activity, but enhanced metabolic stability and increased oral bioavailability. Cryo-EM and site-directed mutagenesis analyses established that Colivin binds to the vanilloid binding pocket of TRPV3, stabilizing one of two distinct non-conducting conformations. Oral administration of Colivin effectively suppressed DSS-induced ulcerative colitis (UC) in wild-type, but not Trpv3-deficient mice. Collectively, our findings establish TRPV3 inhibition as a novel therapeutic strategy for UC, offer key structural insights into the inhibition mechanism of TRPV3, and provide critical structural insights for the rational design of potent and selective TRPV3 inhibitors. - Source: PubMed
Publication date: 2026/08/13
Wang YujingChen JiahuiTang QinglianQin XuWang ShuxianXi ChuchuLu ZhaowenRen KeruiXue ChuShen JianhuaWang KaiZhu Michael XYu JieCao Zhengyu - In traditional Chinese medicine, frankincense is widely recognized for its anti-inflammatory and immunomodulatory capacities and has been conventionally applied to manage multiple chronic inflammatory skin disorders. Nevertheless, its therapeutic potency and molecular mechanisms against atopic dermatitis (AD) remain poorly clarified. This study aimed to explore the protective efficacy of frankincense oil extract (FOE) and its active constituents in AD mouse models, thereby clarifying underlying regulatory mechanisms. Two classic AD models induced by 2,4-dinitrochlorobenzene (DNCB) and carvacrol were established to evaluate the therapeutic performance of FOE and its bioactive components. Hematoxylin-eosin and toluidine blue staining were applied to characterize lesional histopathological alterations, immunohistochemistry was used to detect expression profiles of TRPV3, β-catenin, and COX-2 in skin lesions, and calcium fluorescence imaging was applied to monitor TRPV3-mediated intracellular calcium dynamics. The results showed that FOE markedly alleviated typical AD-like manifestations, reducing inflammatory injury, ear edema and splenomegaly in DNCB- and carvacrol-challenged mice. Histological evaluation confirmed that FOE improved pathological lesions, mitigated epidermal hyperplasia, and reduced mast cell infiltration. Meanwhile, FOE remodeled the abnormal expression patterns of TRPV3, β-catenin, and COX-2 triggered by AD stimulation. Additionally, FOE effectively regulated carvacrol-evoked calcium influx mediated by TRPV3 activation. Collectively, FOE and its active components exert anti-inflammatory effects, restraining epidermal over-proliferation and ameliorating epidermal structural disorders, thereby supporting the restoration of epidermal tissue morphology. Such benefits are attributed to modulating TRPV3 activity and remodeling the cutaneous inflammatory microenvironment. This work highlights FOE as a promising novel candidate for atopic dermatitis intervention. - Source: PubMed
Publication date: 2026/08/06
Tan Gang-NingZhang Wen-ShengLi Yu-SangTang He-Bin