SOX21, affinity purified antibody, goat, 100 ug.
- Known as:
- SOX21, antigenic enriched (anti-), caprine, 100 ug.
- Catalog number:
- GT15173-100
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- SOX21 affinity purified antibody goat 100 .
Ask about this productRelated genes to: SOX21, affinity purified antibody, goat, 100 ug.
- Gene:
- SOX21 NIH gene
- Name:
- SRY-box 21
- Previous symbol:
- -
- Synonyms:
- SOX25
- Chromosome:
- 13q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-14
- Date modifiied:
- 2015-11-23
Related products to: SOX21, affinity purified antibody, goat, 100 ug.
Related articles to: SOX21, affinity purified antibody, goat, 100 ug.
- To explore and characterize gene expression patterns and RNA-seq-derived sequence variation in samples from Chilean patients with low-grade oral epithelial dysplasia (LG-OED) and oral squamous cell carcinoma (OSCC). - Source: PubMed
Publication date: 2026/07/29
Dutra Mateus JoséCortes Patricio MirandaDíaz Valentina Fernanda FernándezVenegas Mauricio Alejandro SáezMorales-Pison SebastiánGonzález-Arriagada Wilfredo AlejandroFernández-Ramires RicardoAdorno-Farias Daniela - Cisplatin resistance is a major obstacle to effective chemotherapy in patients with cervical cancer and is associated with an immunosuppressive tumour microenvironment. Copper ions are essential trace elements that regulate redox and immune balance. However, the connections among copper ions, cisplatin resistance and immune regulation remain unclear. Here, higher serum copper levels correlated with increased pan-cancer mortality. Integrative transcriptomic and single-cell RNA sequencing analyses revealed lower copper-related transcriptional activity in CD8⁺ T cells from cervical cancer tissues. Multiomics analysis revealed that ATPase copper transporting alpha (ATP7A) expression was upregulated in cisplatin-resistant patients compared with sensitive patients and correlated with poor survival. ATP7A knockdown increased sensitivity to cisplatin and promoted cuproptosis, whereas ATP7A overexpression increased cisplatin resistance and impaired CD8⁺ T cells through copper ion efflux. Furthermore, excess copper ions directly bind to the lymphocyte-specific protein tyrosine kinase (LCK) activation loop (Tyr394), impairing T-cell receptor (TCR) signalling in CD8⁺ T cells. Sex-determining region Y-box 21 (SOX21) directly binds two conserved motifs within the ATP7A promoter (-372 bp and -245 bp) and enhances its transcriptional activity. These results revealed a SOX21/ATP7A/copper ion axis connecting copper ion efflux with immune suppression and cisplatin resistance. Targeting ATP7A or copper ion efflux may restore CD8⁺T-cell activity and enhance the efficacy of cisplatin for the treatment of cervical cancer. - Source: PubMed
Publication date: 2026/07/10
Pan ShuangjiaWu QianqianLiu HejingZhou YujiaRuan JiayiJin YuqingHuang LingxiaoZhang Jian'anJi HuihuiZhu Xueqiong - The liver is known to play a pivotal role in modulating blood glucose homeostasis through intrahepatic glucose metabolism. Here, we reveal a unique mechanism by which fatty liver exacerbates hyperglycemia through remote communication from hepatocytes to intestinal stem cells (ISCs), independent of enhanced intrahepatic gluconeogenesis. Mechanistically, hepatocyte-derived alkaline phosphatase (ALP) targets α2δ-1 in ISCs to promote the membrane translocation of Ca1.2. This process triggers increased intracellular calcium levels, which subsequently activates the calcineurin/NFATC2 signaling axis, thereby inhibiting SOX21 expression. Then, decreased expression of SOX21 downregulated bone morphogenetic protein 7 (BMP7), ultimately hindering ISCs differentiation into intestinal L-cells. Consequently, the levels of hypoglycemic enteroendocrine hormones secreted by L-cells are decreased, thereby promoting hyperglycemia. Therapeutically, inhibiting ALP synthesis in fatty liver independently reduces blood glucose and synergistically enhances the hypoglycemic effect of metformin. Our study highlights the role of liver-gut communication in regulating the fate of ISC differentiation and blood glucose homeostasis. - Source: PubMed
Publication date: 2026/06/17
Ye JinbaoWan QianyiLiu XingzhuDeng YawenZhang ZehongChen HaiouGao ChaoxinZhang ShiyuZhu YuedanYan JinhuaYuan YuChen YiChen Haiyang - Glioblastoma multiforme (GBM) is characterized by its aggressive nature and is the most malignant form of glioma, associated with a poor clinical prognosis. This study aimed to evaluate and predict the survival outcomes of GBM patients by developing a prognostic long non-coding RNA (lncRNA) signaling model for GBM. - Source: PubMed
Publication date: 2026/05/22
Yang YanyanSun JiayaoFang YanShan WeiLi PengfeiMa YaxuanNi Weimin - Glutathione peroxidase (GPx), a key antioxidant enzyme, shows altered activity in individuals with schizophrenia. However, the molecular mechanisms behind this alteration remain incompletely understood. In this study, we combined bioinformatics and experimental approaches to explore potential associations between redox-related long non-coding RNAs (lncRNAs) and GPx activity in schizophrenia. - Source: PubMed
Publication date: 2026/05/26
Khaki MahsaMassoudifar AliDavoodian NahidMousavi PegahDavoodian NajmehMahmoudi Masoumeh