MyD88 Antibody
- Known as:
- MyD88 Antibody
- Catalog number:
- 3244R-100
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- MyD88 Antibody
Related genes to: MyD88 Antibody
- Gene:
- MYD88 NIH gene
- Name:
- MYD88 innate immune signal transduction adaptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-23
- Date modifiied:
- 2019-04-23
Related products to: MyD88 Antibody
Related articles to: MyD88 Antibody
- Antibiotics are commonly used to treat Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea, but bacterial resistance is worsening and efficacy is unsatisfactory. Based on the functions of intestinal alkaline phosphatase (IAP) such as degrading lipopolysaccharide (LPS), anti-inflammation, and enhancing intestinal barrier function, this study evaluated its therapeutic effect in mice. Thirty SPF BALB/c mice were randomly divided into five groups: the control group, the ETEC model group, and three IAP intervention groups (200, 300, and 400 U/mL). All groups received daily gavage for 3 consecutive days: the Control and ETEC groups were given phosphate-buffered saline (PBS), while the three IAP groups received IAP at their respective doses. On day 4, the model and intervention groups were pretreated with cimetidine followed by ETEC challenge. On day 7, intestinal permeability, inflammatory factors, barrier function, morphological structure, and intestinal LPS level were detected. Results showed IAP alleviated weight loss and reduced disease activity index (DAI), with 400 U/mL restoring DAI to baseline within 96 hours. The 300 and 400 U/mL groups degraded LPS content in colonic contents, reduced bacterial load in the liver, improved jejunal morphology, upregulated Occludin, ZO-1, MUC2 expressions, enhanced antioxidant capacity, and downregulated inflammatory factors and TLR4/MyD88/NF-κB pathway genes (all P<0.05). The 400 U/mL group further reduced diamine oxidase and D-lactate (P<0.05). In conclusion, IAP effectively alleviated ETEC-induced diarrhea in mice, providing a theoretical basis for the development of novel therapeutic agents against diarrhea. - Source: PubMed
Publication date: 2026/06/16
Wang ShuaidongZhang YangZhang XiaoqianMa LeXu ZekangWei QuanHua Song - Fine particulate matter (PM) has become a severe environmental hazard in intensive poultry farming, which commonly triggers respiratory impairment and further deteriorates the growth performance and health status of broilers. Developing feasible dietary additives to relieve PM-caused toxic damage is urgently required for the modern poultry industry. Rosmarinic acid (RA) is a naturally occurring polyphenolic compound with validated anti-inflammatory and antioxidative capacities; nevertheless, whether dietary RA can ameliorate pulmonary damage induced by PM pollution in broilers remains poorly understood. The present study aimed to explore the protective potential and molecular mechanisms of RA against PM-mediated lung injury in broiler models. A total of 144 male Arbor Acres (AA) broilers at 21 days of age were randomly assigned to three groups: control group (CON), PM exposure group (PM), and PM exposure supplemented with 200 mg/kg RA group (RA). The experimental feeding period lasted for 21 days. The results showed that RA supplementation effectively mitigated pulmonary inflammatory lesions caused by PM exposure, which was accompanied by improved lung histological morphology and decreased secretion of inflammatory cytokines (IL-6, IL-10, TNF-α, and IFN-γ). Molecular detection confirmed that RA intervention effectively inhibited the overactivation of the TLR4/MyD88/NF-κB inflammatory cascade. Moreover, dietary RA reshaped the pulmonary microbial community structure by elevating bacterial richness and evenness. The relative abundances of beneficial bacterial genera (Turicibacter, Hydrogenophilus, and Actinoplanes) were enriched, whereas taxa including Ammoniibacillus, Thermobacillus, and Hyphomicrobium were depleted. Untargeted metabolomic analysis screened a total of 66 differential metabolites, which were mainly annotated to tryptophan metabolism, tricarboxylic acid (TCA) cycle, arginine biosynthesis, and glycerophospholipid metabolism pathways. Collectively, these results demonstrate that 200 mg/kg dietary RA protects broilers from PM-triggered pulmonary injury via inhibiting the TLR4/MyD88/NF-κB inflammatory pathway, optimizing lung microbial composition, and regulating metabolic patterns. This research offers empirical evidence to support the application of RA as a promising feed additive for maintaining respiratory health of broilers exposed to PM contamination. - Source: PubMed
Publication date: 2026/06/10
Zhou YingXu BinWang DongLi ShaoyuDeng Wen - Maternal obesity contributes to programming of offspring obesity. A causal pathway for placental inflammatory changes in utero with obesity remains to be established. We examined the role of the toll-like receptor (TLR) pathway in mediating maternal obesity associated changes in placental gene expression using trophoblast-specific deletion of the TLR adapter protein, MyD88. - Source: PubMed
Publication date: 2026/06/10
Ruebel Meghan LZhong YingSchall Peter ZJambal PurevsurenYazza Deaunabah NZemski Berry KarinChintapalli Sree VRead Quentin DThakali Keshari MShankar Kartik - Obesity is largely driven by Western diets and sedentary lifestyles and is linked to a range of metabolic and neuropsychiatric disorders. Accumulating evidence suggests that a high-fat diet (HFD) contributes not only to metabolic dysfunction but also to neuroinflammatory processes and mood disturbances such as anxiety and depression. The mechanisms through which polysaccharides extracted from L. (PEP), an α-acidic pyran heteropolysaccharide (1.226 × 10 kDa) rich in galactose and galacturonic acid, exert beneficial effects on behavior have not been fully elucidated. In this study, we investigated the potential of PEP to attenuate HFD-induced anxiety- and depression-like behaviors in mice. Behavioral analyses revealed significant improvements in both exploratory and stress-related behaviors following PEP administration. At the molecular level, PEP significantly reduced the expression of pro-inflammatory cytokines compared with the HFD group ( < 0.05), including TNF-α (16.98 24.11 pg per mg protein), IL-1β (3.45 5.22 pg per mg protein), IL-6 (3.06 7.23 pg per mg protein), and MCP-1 (4.53 7.36 pg per mg protein). In contrast, PEP significantly increased the levels of anti-inflammatory mediators ( < 0.05), including IL-4 (28.86 21.45 pg per mg protein) and IL-10 (8.15 2.10 pg per mg protein). Furthermore, PEP modulated the TLR4/MyD88/NF-κB signaling cascade and exerted bidirectional regulation on the AMPK/mTOR axis, upregulating AMPK while inhibiting mTOR expression, suggesting promotion of autophagic activity. These findings indicate that PEP confers neuroprotective effects by dampening neuroinflammation and improving behavioral outcomes. Collectively, our results support the potential application of PEP as a natural preventive agent for the management of diet-induced mood disorders. - Source: PubMed
Publication date: 2026/06/08
Huang Yu-TienChen Sheng-YiHsu Yi-HsienYen Gow-Chin - This investigation sought to determine hsa_circ_0003218's role and mechanism in trophoblast dysfunction during gestational diabetes mellitus (GDM). - Source: PubMed
Zhang Xiao-FengWei Luo-HongWu Yu-DanLi Xiao-HuiWang Zhi-FenJu Ya-Ru