MyD88 Antibody
- Known as:
- MyD88 Antibody
- Catalog number:
- 3244R-100
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- MyD88 Antibody
Related genes to: MyD88 Antibody
- Gene:
- MYD88 NIH gene
- Name:
- MYD88 innate immune signal transduction adaptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-23
- Date modifiied:
- 2019-04-23
Related products to: MyD88 Antibody
Related articles to: MyD88 Antibody
- Adverse outcome pathways (AOPs) describe toxicity across levels of biological organization by measurable key events (KEs), thus providing a structured framework for predicting population-level effects. Here, mussels were exposed to different temperature conditions-22 °C and marine heatwave (MHW), in combination with nano-titanium dioxide (nano-TiO) at 0, 25, and 250 μg/L. High-concentration nano-TiO and MHW exposure promoted the secretion of byssal threads and enhanced the adhesion to the substrate. However, they also caused severe histopathological damage in the foot and reduced the condition index (CI), indicating serious organism-level adverse outcomes (AOs). Accumulation of lipid peroxidation (LPO) products and redox imbalance suggested that MHW and nano-TiO induced oxidative stress, leading to increased cell apoptosis (CA), reduced cell viability (CV), and consequent tissue damage in the foot. Nano-TiO and MHW exposure significantly upregulated adhesion-related genes () as well as immune- and cytotoxicity-related genes (, , , and ). In contrast, and pre-collagen proteins () were significantly downregulated, resulting in poor extensibility of byssal threads. Using the AOP framework, this study links nano-TiO toxicity and MHW-induced stress to molecular disruptions, organism-level adverse outcomes, and altered mussel byssal defenses. These findings highlight that the interaction between MHW and nanoparticles may compromise mussel attachment and survival, with potential implications for the stability of coastal benthic ecosystems under future climate change scenarios. - Source: PubMed
Publication date: 2026/07/17
Wei ShuaishuaiTu ZhihanSokolova InnaChen LimingWang ShixiuHu MenghongWang Youji - To summarize current evidence on clinical features, multimodal imaging findings, diagnostic techniques, and management strategies for vitreoretinal lymphoma. - Source: PubMed
Publication date: 2026/08/13
Maitray AdityaRishi PukhrajConrady Christopher DBinkley ElaineWilliams Basil KYeh StevenNicola Maura DiFinger Paul T - Animal-origin extended-spectrum -lactamase-producing (ESBL-) undermines cefquinome (CEF) efficacy in veterinary medicine, necessitating strategies that enhance antibacterial activity while protecting intestinal integrity. Here, we evaluated baicalin (BAI), a flavonoid from , as a CEF adjuvant against animal-origin ESBL-. In a mouse intestinal infection model, BAI combined with CEF significantly improved survival, mitigated intestinal pathology, and downregulated , , and NF-κB signaling. The combination preserved mucosal architecture and partially restored intestinal microbiota composition. , BAI potentiated CEF activity by suppressing gene expression, reducing ESBL-mediated CEF hydrolysis, and limiting the emergence of reduced CEF susceptibility during serial passage. Docking suggested a potential interaction of BAI with the catalytic site of CTX-M-9; together with reduced cefquinome hydrolysis in whole-cell suspensions, this suggests interference with ESBL-mediated hydrolysis. These results demonstrate that BAI functions as a CEF sensitizer, integrating pathogen-directed and host-protective effects, and offer a translationally relevant strategy for veterinary antibiotic adjuvant therapy. - Source: PubMed
Publication date: 2026/07/31
Jiang Yu-HanZhu Lei-XinCheng Zi-XuSun Shao-QiangZhang Wei-MinQing Su-Zhu - Cyanobacterial blooms release microcystin-LR (MC-LR), which threaten aquatic organisms; yet the subchronic effects on fish intestinal mucosal immunity, and whether exposure route modulates injury progression, remain poorly understood, especially the key mechanism involved. Here, common carp were subjected to 21-day subchronic exposure via immersion in Microcystis aeruginosa PCC 7820 (10 cells/L) or intraperitoneal injection of MC-LR (3 μg/kg·bw). Both routes induced intestinal mucosal barrier damage, evidenced by disordered intestinal villi, impaired tight junctions, downregulated zo-1, occludin, claudin-3, and muc-2 expression, and reduced mucus secretion. 16S rRNA sequencing revealed gut microbiota dysbiosis with increased pathogenic bacteria, alongside elevated lipopolysaccharide and reduced butyric acid. Oxidative stress (elevated MDA but reduced GSH and T-SOD) and pro-inflammatory shifts (upregulated il-1β, tnf-α, il-6 but downregulated il-10) were observed. Mechanistically, the elevated LPS from gut dysbiosis activated the TLR4/MyD88/NF-κB signaling pathway at transcriptional and protein levels, suggesting a link between microbiota changes and intestinal inflammation in carp. Mucosal immunoglobulins (IgT and IgD) declined after 21 days of exposure, while IgM increased compensatorily. Injection induced earlier onset than immersion, yet both routes converged on similar endpoints by day 21, showing that exposure route affects timing more than final outcome severity. These findings not only elucidate a microbiota-LPS inflammatory axis underlying MC-LR immunotoxicity in fish, but also provide unique comparative temporal evidence for ecological risk assessment of cyanobacterial blooms. - Source: PubMed
Publication date: 2026/08/14
Ding CuihongSong YunxiaDing WeikaiMa JunguoLi Xiaoyu - Hyperuricemia (HUA) is a metabolic disorder with an escalating global prevalence, and its progression to HUA-associated nephropathy represents an important contributor to chronic kidney injury. Emerging evidence highlights a bidirectional relationship between uric acid and lipid metabolism, with dyslipidemia contributing to the pathological progression of HUA-related complications. Triphala (TRP), a classic Tibetan herbal formula with broad metabolic regulatory properties, was selected as a potential intervention for the complex metabolic disturbances associated with HUA. However, its therapeutic efficacy and the precise molecular mechanisms underlying its effects in HUA remain to be fully elucidated. - Source: PubMed
Publication date: 2026/08/06
Liu CongZhang HuanZhang HuihuiZhao YiWu ChenLin QinxiongLuo YubinWei LiangkaiChen JianqiuRao XinyuXiong SiyiShen HanmengHong ShuyanShi ZhaohuaYin ShijinLan ZhouChen Lvyi