MyD88 Antibody
- Known as:
- MyD88 Antibody
- Catalog number:
- 3244R-100
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- MyD88 Antibody
Related genes to: MyD88 Antibody
- Gene:
- MYD88 NIH gene
- Name:
- MYD88 innate immune signal transduction adaptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-23
- Date modifiied:
- 2019-04-23
Related products to: MyD88 Antibody
Related articles to: MyD88 Antibody
- Primary large B-cell lymphoma of immune-privileged sites (IP-LBCL) is an aggressive B-cell lymphoma arising in the central nervous system, vitreoretina, and testis, whereas the molecular features of IP-LBCL with IRF4 rearrangement (IP-LBCL-IRF4-R) remain poorly characterized. Here, we report seven cases of IP-LBCL-IRF4-R, all showing IRF4 rearrangement confirmed by fluorescence in situ hybridization. The cohort included six males and one female, with a median age of 58 years (range, 34-73 years); all patients were immunocompetent. Tumors involved the central nervous system (n = 4) and testis (n = 3). With a median follow-up of 10 months (range, 3-45 months), all patients were alive. Histologically, all IP-LBCL-IRF4-R cases showed diffuse proliferation of medium-to-large B cells with centroblast-like and/or immunoblast-like morphology. Immunophenotypically, one case was classified as the germinal center B-cell subtype and six as the non-germinal center B-cell subtype. Five cases showed BCL2/C-MYC double expression, and all seven cases were negative for Epstein-Barr virus-encoded small RNA. IRF4 rearrangement was detected in all seven cases by break-apart probes, and an IGH::IRF4 fusion was detected in only one case; three cases harbored BCL6 rearrangements, and no BCL2 or MYC rearrangements were detected. Next-generation sequencing identified recurrent mutations in IRF4 and PIM1 (6/7, 85.7% each), followed by MYD88 (5/7, 71.4%) and BTG1, CD79B, and LRP1B (3/7, 42.9% each). LymphGen 2.0 classified five cases as the MCD subtype and two as Other. Our study highlights IRF4 rearrangement as a rare genetic event in IP-LBCL and provides further insights into the molecular diversity of this entity. - Source: PubMed
Publication date: 2026/09/17
Zhang YuxiuLi AnqiLi YiminZhang LeiZhang LiliLi LeiHuang YufengDu LinlinHuang JieDong LeiXu HaiminOuyang BinshenYi HongmeiWang ChaofuHou Yingyong - With rising global temperatures, the detrimental effects of heat stress on the reproductive performance of female animals have received increasing attention. In this study, we investigated the effects of heat stress on reproductive function in female mice and explored the therapeutic potential of probiotics in alleviating uterine damage through repair of the intestinal barrier. Seven-week-old female ICR mice were used to establish a systemic heat stress model. Mice in the treatment groups received Enterococcus faecium or Clostridium butyricum during heat stress. The results showed that heat stress induced systemic inflammation, oxidative stress, and elevated endotoxin (LPS) levels, leading to downregulation of tight junction proteins (ZO-1, occludin, and claudin-1) in the colon and uterine tissues. Systemic inflammation increased the levels of the pro-inflammatory cytokines IL-1β and IL-2 while decreasing the levels of the anti-inflammatory cytokines IL-4 and IL-10 in uterine tissue, resulting in uterine inflammatory damage and reproductive hormone dysregulation, thereby exacerbating placental injury and increasing the risk of fetal growth restriction. Treatment with E. faecium or C. butyricum repaired the intestinal barrier and inhibited the TLR4-MyD88 signaling pathway, thereby protecting the uterus from heat stress-induced injury and effectively alleviating uterine inflammation and fetal growth restriction. The 16S rRNA sequencing results demonstrate the regulatory effects of Enterococcus faecium and Clostridium butyricum on intestinal microbiota. Fecal microbiota transplantation (FMT) experiments further demonstrated that oxidative stress and uterine inflammatory damage in heat-stressed mice were alleviated following transplantation of intestinal microbiota from mice treated with E. faecium or C. butyricum. These findings suggest that E. faecium and C. butyricum have potential applications in reducing heat stress-induced reproductive damage in female animals. - Source: PubMed
Publication date: 2026/09/16
Zhou HongdaChen MengweiWang XueqinPan YingLiu XinyuAn JinboLiu ZhipengMa BaohuaPeng Sha - IL-33 is an alarmine released upon tissue injury. Mast cells (MCs) highly express the IL-33 receptor T1/ST2 (IL-33R) and are thus highly susceptible to released IL-33. Activation of the IL-33R on MCs induces the MyD88-dependent activation of the TAK1-IKK2-p65/RelA signaling pathway, ERK1/2 and p38 which together mediate the production of IL-6, IL-13 and IL-2. Whereas MC-derived IL-6 and IL-13 act as pro-inflammatory cytokines, MC-derived IL-2 acts as an anti-inflammatory cytokine by inducing T cell expansion in vitro and in vivo. The mechanism, which mediate this pleiotropic nature within IL-33-activated MCs is unknown. We hypothesized that precisely balanced signaling pathways define whether MCs act as pro-inflammatory cells by the production of IL-6 and IL-13, or as anti-inflammatory cells by the production of IL-2. Surprisingly, we identified Ca as the determinant factor, which balances the IL-33-induced production of IL-6, IL-13 and of IL-2. Thereby, whereas Ca activates the Calcineurine (CaN)-NFATc2-ERK1/2 signaling pathway, which selectively mediates the production of IL-2, Ca simultaneously limits the activation of p38 and the subsequent production of IL-6 and IL-13 in IL-33-activated MCs. Given that IL-2 producing MCs act as anti-inflammatory cells, our data show that the Ca-CaN-NFATc2-ERK1/2 signaling pathway determines the anti-inflammatory potential of IL-33-activated MCs. - Source: PubMed
Publication date: 2026/09/10
Wagner StellaKüchler ClaudiaHornung KatrinDrube Sebastian - To identify gene mutations associated with chemotherapeutic resistance in patients with vitreoretinal lymphoma (VRL) using metagenomic deep sequencing (MDS) of intraocular specimens. - Source: PubMed
Publication date: 2026/09/17
Pothikamjorn Thananop LDoan Thuy AHinterwirth ArminStewart Jay MGonzales John A - Benzalkonium chloride (BAK), a quaternary ammonium antimicrobial agent widely utilized in ophthalmic formulations, is associated with chronic ocular surface toxicity. BAK induces corneal epithelial inflammation and autophagic impairment, yet their interrelationship remains unclear. - Source: PubMed
Publication date: 2026/09/17
Du JingYu ZheXiao YangLi JingWei ShengshengLi YongYan Jin