Cdc25c
- Known as:
- Cdc25c
- Catalog number:
- MA1018
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- SDlabs
- Gene target:
- Cdc25c
Related genes to: Cdc25c
- Gene:
- CDC25C NIH gene
- Name:
- cell division cycle 25C
- Previous symbol:
- CDC25
- Synonyms:
- PPP1R60
- Chromosome:
- 5q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-06
- Date modifiied:
- 2017-12-06
Related products to: Cdc25c
Related articles to: Cdc25c
- Gallbladder carcinoma (GBC) is the most common malignancy of biliary tract with a dismal prognosis. Previous studies have confirmed that oprozomib has inhibitory effects on a variety of tumors. We aim to investigate the anti-tumor effects of oprozomib on GBC and explore the potential mechanisms. In this study, we demonstrated that oprozomib had significant anti-tumor effect on SGC-996, NOZ, and GBC-SD GBC cell lines in vitro and inhibited GBC tumor growth of SGC-996 and GBC-SD cells xenograft model and exhibited no significant toxicity in vivo. Mechanistically, oprozomib induced SGC-996 and GBC-SD cells G2/M phase arrest through ERK/MAPK signaling pathway as evidenced by the decrease in the expression of CDK1 and Cdc25C, while an increase in the expression of p-ERK, p21, and p27, and apoptosis via JNK/ p38 MAPK signaling pathway as evidenced by an increase in the expression of p-JNK, c-Jun, p-c-Jun, p-p38, Cytochrome c, Cleaved Caspase-8, and Cleaved Caspase-9, while a decrease in the expression of Bcl-2. Oprozomib could induce G2/M phase arrest and apoptosis via MAPK signaling pathway. In addition, our findings provide preclinical evidence for understanding the mechanism and the development of oprozomib-based regimen as a novel potential chemotherapeutic agent against GBC in the future. - Source: PubMed
Publication date: 2026/07/28
Liu FeiDai Yu-ShiHu Hai-JieMa Wen-JieJin Yan-WenWu Zhen-RuWang Jun-KeShi Yu-JunLi Fu-Yu - Studies have shown that PANoptosis is increasingly involved in cancer and cancer treatment. The Cordycepin has also been found to be involved in the development of various cancers. However, relevant research on both in lung adenocarcinoma (LUAD) remains relatively scarce. The present study aims to identify potential prognostic genes in LUAD and elucidate their impact on the prognosis of LUAD patients, with the goal of providing novel insights into the therapeutic strategies for this disease. - Source: PubMed
Publication date: 2026/06/08
Xu HaoranHuang WenhuiYang QingChen YueweiSu PeiyuanFu Bing - Oral squamous cell carcinoma (OSCC) remains a substantial global health burden. According to the latest global cancer statistics, it accounts for an estimated 300,000 new cases and 100,000 deaths annually. This study aimed to investigate the pharmacological effects of digitoxin, a cardenolide glycoside, on the modulation of proliferative capacity and apoptotic induction in human OSCC human tongue squamous carcinoma (HSC-3) cells. - Source: PubMed
Publication date: 2026/03/23
Rui YingWang YanGong HongfeiZhu XuanyuXu QingLin JingWei Jingchen - Sinonasal inverted papilloma is a locally aggressive epithelial lesion with a relatively high recurrence rate, yet the molecular basis of its proliferative behaviour remains incompletely understood. This study investigated the clinical relevance of secreted phosphoprotein 1 in sinonasal inverted papilloma and its association with epithelial cell proliferation and related signalling pathways. - Source: PubMed
Publication date: 2026/04/28
Tang WenruiWang LinYan XudongZhang JishengYu LonggangChen HanZheng ChungeDong ZihuiZheng QianyouHan LinJiang Yan - Polyethylene terephthalate (PET), one of the most widely used synthetic polymers globally, has emerged as a potential environmental risk factor for human health. However, the molecular mechanisms linking PET exposure to hepatocellular carcinoma (HCC) remain poorly understood. - Source: PubMed
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