INsL3
- Known as:
- INsL3
- Catalog number:
- PA1044
- Product Quantity:
- 100μg
- Category:
- -
- Supplier:
- SDlabs
- Gene target:
- INsL3
Related genes to: INsL3
- Gene:
- INSL3 NIH gene
- Name:
- insulin like 3
- Previous symbol:
- RLNL
- Synonyms:
- RLF, MGC119818, MGC119819
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-02
- Date modifiied:
- 2018-03-22
Related products to: INsL3
anti-INsL3anti-INsL3 , Rabbit polyclonal to INsL3 , Isotype IgG, Host RabbitAnti-INSL3 AntibodyAnti-INSL3 antibodyAnti-INSL3 AntibodyBovine Insulin-like 3(INSL3) ELISA kitCanine Insulin-like 3(INSL3) ELISA kitCanine Insulin-like 3(INSL3) ELISA kitCanis familiaris,Canis lupus familiaris,Dog,INSL3 receptor,Leucine-rich repeat-containing G-protein coupled receptor 8,LGR8,Relaxin family peptide receptor 2,Relaxin receptor 2,RXFP2Chicken INSL3 (Insulin Like Protein 3) ELISA KitChicken INSL3 (Insulin Like Protein 3) ELISA KitChicken Insulin-like 3(INSL3) ELISA kitDog insulin-like 3 (INSL3) ELISA KitDog insulin-like 3 (INSL3) ELISA KitDog insulin-like 3 (INSL3) ELISA Kit SpeciesDog Related articles to: INsL3
- Circulating insulin-like peptide 3 (INSL3) is a constitutively secreted product of mature Leydig cells and is considered a stable biomarker of Leydig cell functional capacity, a key determinant of androgenic status across the male lifespan. Since the adult Leydig cell population is established during late childhood and puberty, nutritional and metabolic exposures during these periods may contribute to later variation in young adult INSL3. To investigate whether childhood and adolescent nutritional/metabolic markers, particularly vitamin D, fatty acids, amino acids, and dietary trace-element intake, are associated with circulating INSL3 concentrations in young adulthood. Data were analysed from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based UK birth cohort. Nutritional and metabolic markers measured during childhood and adolescence included vitamin D, fatty acid-related traits, glutamine, leucine, dietary zinc intake, and dietary selenium intake. Associations with circulating INSL3 at 17 and 24 years were first explored using bivariate correlation analysis. Variables showing signals of interest were then examined in multiple linear regression models using log-transformed data and relevant covariates, including BMI at 8 years and log-transformed exact age at the age-24 clinic visit. Among the variables examined, vitamin D at 9 years showed a small positive association with INSL3 at 24 years (r = 0.098, n = 735, = 0.008), remaining below the corrected threshold after both Benjamini-Hochberg and Bonferroni correction (q = 0.032 and Bonferroni-adjusted = 0.032). This relationship remained evident after adjustment for BMI at 8 years and after further adjustment for log-transformed exact age at the age-24 clinic visit. In these multivariable models, BMI at 8 years showed little evidence of association with INSL3 at 24 years, whereas log-transformed exact age at the age-24 clinic visit showed a negative association with INSL3. In contrast, no meaningful associations were observed for fatty-acid-related measures. Among amino acids and dietary trace-element measures, glutamine at 17 years showed a weak nominal positive association with INSL3 at 24 years, but this did not remain below the threshold after multiple-testing correction. Childhood vitamin D status, particularly at 9 years of age, may represent an early-life factor associated with variation in adult Leydig cell functional capacity. Fatty acid-related measures showed no clear associations, while glutamine yielded only a weak exploratory signal. These findings support the concept that the childhood metabolic environment may influence the developmental establishment of adult Leydig cell capacity. - Source: PubMed
Publication date: 2026/07/24
Tulumcu BilalIvell RichardAnand-Ivell Ravinder - Rheumatoid arthritis and its glucocorticoid-based treatment may adversely affect male reproductive function by disrupting spermatogenesis, steroidogenesis, and testicular homeostasis. Insulin-like peptide 3 (INSL3), a Leydig cell-derived peptide hormone and marker of Leydig cell functional capacity, may contribute to the maintenance of testicular function through its steroidogenic and anti-inflammatory effects. In the present study, we investigated the effects of prednisolone and INSL3, administered alone or in combination, on testicular structure and function in rats with adjuvant-induced arthritis. Adult male rats were allocated to seven groups: control, prednisolone, INSL3, arthritis, arthritis + prednisolone, arthritis + INSL3, and arthritis + prednisolone + INSL3. Testicular alterations were evaluated using histological, morphometric, immunohistochemical, ultrastructural, testosterone, and sperm analyses. Arthritis was associated with reduced testicular weight, decreased seminiferous tubule diameter and epithelial thickness, impaired sperm parameters, lower serum and intratesticular testosterone levels, increased testicular tumor necrosis factor-α and interleukin-6 immunoreactivity, and reduced 3β-hydroxysteroid dehydrogenase and proliferating cell nuclear antigen immunoreactivity. In arthritic rats, prednisolone or INSL3 alone was associated with partial improvement in selected testicular parameters, whereas combined treatment was associated with improvement across several inflammatory, morphometric, steroidogenic, and sperm-related parameters. These findings suggest that INSL3 treatment is associated with partial attenuation of inflammation-related testicular injury and improvement in selected reproductive parameters under inflammatory and glucocorticoid stress. Further studies are required to clarify whether these effects are mediated by direct intratesticular mechanisms or indirect systemic pathways. - Source: PubMed
Publication date: 2026/08/07
Coskun GulfidanSapmaz TugceSaker DilekKara SametSencar LemanDogus YusufPolat Sait - Brain age is a global measure that compares structural brain MRI with large reference datasets. Predicted age deviation (PAD) is the deviation between predicted brain age and chronological age, with positive values indicating advanced aging. Identifying blood-based biomarkers that approximate brain PAD could provide an accessible and cost-effective measure of brain health as an alternative to MRI, but no blood-based biomarkers have yet been identified. This study aimed to investigate novel blood-based biomarkers associated with accelerated PAD using an unbiased proteomics approach to discover new biomarkers. - Source: PubMed
Publication date: 2026/07/09
Gill Jessica MLim ArumEsopenko CarrieYun SijungYun JosephDark Heather EAlice JohnKenney KimbraHentig JamesPugh Mary JoWalker William CCifu Davidde Souza Nicola LDennis Emily LWilde Elisabeth A - Childhood obesity is a major endocrine and metabolic disorder that extends beyond cardiometabolic risk and may affect male reproductive development. Cryptorchidism (undescended testis, UDT) is a common congenital anomaly associated with hypogonadism, subfertility, and testicular cancer. However, endocrine and metabolic links between obesity and impaired testicular descent remain incompletely integrated. - Source: PubMed
Publication date: 2026/07/03
Zhang DeweiLi QiurongYang ZhaoNong RentaoZhanghuang ChenghaoYan Bing - Oocyte in vitro maturation (IVM) is a critical step for in vitro embryo production. Compared with the in vivo system, conventional IVM lacks paracrine support, resulting in reduced oocyte quality. Insulin-like peptide 3 (INSL3), an ovarian paracrine factor, has been shown to be involved in follicular development and oocyte maturation. However, whether INSL3 plays a role in sheep oocyte IVM remains unclear. This study investigated the effects of INSL3 on IVM of sheep oocytes and subsequent embryonic development. Our results showed that supplementation with 10 ng/mL INSL3 significantly increased the polar body extrusion (PBE) rate compared with the control group (77.71% vs. 52.74%, P < 0.05), reaching levels comparable to the EGF group. INSL3 also enhanced cumulus expansion and upregulated expansion-related genes (PTX3, HAS2, PTGS2, TNFαIP6). In addition, INSL3 reduced intracellular reactive oxygen species (ROS), improved mitochondrial function, and decreased early apoptosis, as indicated by a lower BAX/BCL-2 ratio. Following in vitro fertilization, oocytes matured with 10 ng/mL INSL3 exhibited higher cleavage (78.62% vs. 67.68%), morula (52.64% vs. 36.64%), and blastocyst rates (35.07% vs. 25.28%) than the control group (P < 0.05), with results comparable to EGF. In conclusion, INSL3 supplementation during IVM improves oocyte quality and developmental competence in sheep, potentially through regulation of cumulus cell function, oxidative status, and mitochondrial activity, and may serve as a promising factor in sheep embryo production technologies. - Source: PubMed
Publication date: 2026/07/14
Yang QiZhang Rui-FengJiang Zhao-YuSun DuiTang Rui-HaoZhang Xiao-YiLi Yi-TongLi Wen-YingLiu AoZhang Chun-LanJia Zhi-WenFeng Meng-LeiXue Fang-RuiSong Chun-RuZhang Xiao-JieLiang Cheng-Guang