CD62E (ELAM-1) Adhesion Molecule Antibody
- Known as:
- CD62E (ELAM-1) Adhesion Molecule Antibody
- Catalog number:
- MAB354P
- Product Quantity:
- 5 ml
- Category:
- -
- Supplier:
- INNOVEX
- Gene target:
- CD62E (ELAM-1) Adhesion Molecule Antibody
Related genes to: CD62E (ELAM-1) Adhesion Molecule Antibody
- Gene:
- SELE NIH gene
- Name:
- selectin E
- Previous symbol:
- ELAM1, ELAM
- Synonyms:
- ESEL, CD62E
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-08-25
Related products to: CD62E (ELAM-1) Adhesion Molecule Antibody
Related articles to: CD62E (ELAM-1) Adhesion Molecule Antibody
- The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the toxicity of these compounds is not fully known due to a lack of scientific data. Nori (Porphyra spp.), a common red seaweed and potential feed and food candidate, contains arsenosugar-phosphate (As-Sug-PO) as a primary As species. In this study, As-Sug-PO was isolated from nori by solid-phase extraction (SPE) and subsequently evaluated for in vitro toxicity in primary salmon hepatocytes. The As-Sug-PO isolate, alongside As reference standards (arsenite As(III) and dimethylarsinic acid (DMA(V)), and arsenic-containing hydrocarbon (AsHC-360)), were assessed for cytotoxicity (mitochondrial activity) and for transcriptional effects on genes associated with lipid biosynthesis, inflammation and oxidative stress by reverse transcription-quantitative polymerase chain reaction (RT‑qPCR). Impacts on total As and As speciation were quantified in both cell pellets and culture medium using high-performance liquid chromatography (HPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS). High concentrations of As-Sug-PO caused cytotoxicity and mitochondrial damage, while lower levels influenced triglyceride biosynthesis, indicating impaired lipid deposition. As(III) was the most toxic As species, followed by As-Sug-PO and DMA(V) and unlike As(III), As-Sug-PO and DMA(V) did not alter total As levels and speciation profile in samples after 48 h of exposure. Follow-up in vivo studies with commercial standards are needed to confirm effects on lipid deposition and to support the establishment of regulatory limits for As-Sug-PO in feed and food. - Source: PubMed
Publication date: 2026/04/02
Ghazali MohammadSele VeronikaSahuquillo AngelesMorales-Rodríguez AlbaSilva Marta SofiaLópez-Sánchez Jose FerminDonald CareyBerntssen Marc H GSøfteland Liv - Kashin-Beck disease (KBD) primarily impairs the epiphyseal plate in children and adolescents, resulting in enlarged bone ends and short stature. Given the abundance of type H vessels in the growing epiphyseal plate, this spatiotemporal correlation prompted us to investigate their potential role in KBD. - Source: PubMed
Publication date: 2026/04/16
Wan XufengDu HaoZhang YaoCai YongruiChen AnjingLiu XiaoyangSu QiangChen XumingDu ZeChen YangmengfanTang HaiweiZhou XinranWang DuanZhou Zongke - Both personality traits and personality disorders have been linked to suicide risk in youth. The DSM-5 Alternative Model of Personality Disorders (AMPD) allows dimensional assessment of personality pathology, which may enhance prediction of suicide attempts. A recent study found that personality dysfunction (Criterion A of the AMPD) is associated with past suicide attempts in adolescents. Building on this, the present study aimed to investigate the longitudinal relationship between AMPD personality pathology and suicide attempts in adolescents. - Source: PubMed
Publication date: 2026/04/15
Zippert Lea KassandraHertel ChristianSele SilvanoReichl CorinnaCavelti MarialuisaKoenig JulianKaess Michael - Glucagon-like peptide-1 (GLP-1) medicines improve metabolic liver disease through weight-loss-dependent and -independent actions. Here, we interrogated semaglutide's action in mice with metabolic dysfunction-associated steatohepatitis (MASH). In Glp1r mice resistant to GLP-1RA-induced weight loss, semaglutide improved steatosis, fibrosis, and immune remodeling. GEM-X Flex-seq localized Glp1r expression to pericentral liver sinusoidal endothelial cells (ECs) (LSECs) and CD8 T cells. EC Glp1r deletion in Glp1r mice or AAV8-Cre-mediated hepatic EC Glp1r knockdown substantially abrogated semaglutide's hepatic benefits despite preserved weight loss. Transcriptomic profiling revealed that Glp1r LSECs adopt a stress-responsive phenotype in MASH that is reversed by semaglutide. Glp1r LSECs function as dominant contributors to semaglutide-regulated circuits linked to injury and repair involving VWF, SELE, CEACAM, and BMP. Molecular profiling revealed semaglutide-coordinated transcriptional and protein-level reversal of disease signatures. Together, the data using mouse models of MASH reveal an EC-specific, weight-loss-independent, semaglutide-regulated, GLP-1R-dependent intrahepatic network for improving liver health. - Source: PubMed
Publication date: 2026/04/14
Gonzalez-Rellan Maria JRiobello CristinaFang SusannaMartins da Silva EloisaKoehler Jacqueline AShang RuiHammoud RolaCao XieminVarela-Rey MartaDrucker Daniel J - Adolescents engaging in non-suicidal self-injury (NSSI) have been reported to show altered autonomic nervous system (ANS) function, indexed by decreased heart rate variability (HRV) and increased heart rate (HR). Preliminary findings in adolescents with borderline personality disorder (BPD) traits suggest, that improvement in ANS function is longitudinally associated with clinical improvement and that ANS activity predicts clinical outcome. Existing studies, however, are limited by small sample sizes and short follow-ups. N = 227 help-seeking adolescents with NSSI disorder who presented to an early intervention service for BPD participated in baseline and two yearly follow-up assessments (N = 81, N = 37), including comprehensive clinical diagnostics as well as recordings of resting electrocardiography. Associations between HR, HRV and clinical outcomes of interest (i.e., NSSI frequency, depression severity, number of BPD criteria and global functioning) were examined using structural equation modelling. While multivariate models showed no evidence for an association between HRV or HR and any of the clinical outcomes, there was evidence from models including cross-lagged effects, that HRV and HR predicted depression severity, number of BPD criteria (HRV only) and global functioning at subsequent assessments. This effect was not observed for NSSI frequency. Improvements in ANS function, indexed by an increase in HRV and decrease in HR, seem to precede the improvement of clinical symptoms in adolescents engaging in NSSI. Findings have clinical implications, suggesting that targeting ANS function as adjuvant treatment in adolescents engaging in NSSI is warranted, and routine monitoring of ANS function my guide clinical decision making. - Source: PubMed
Publication date: 2026/04/03
Koenig JulianMürner-Lavanchy Ines MHedinger NicoleSele SilvanoKaess Michael