CD103 Antibody
- Known as:
- CD103 Antibody
- Catalog number:
- MAB347C
- Product Quantity:
- 0.5 ml
- Category:
- -
- Supplier:
- INNOVEX
- Gene target:
- CD103 Antibody
Related genes to: CD103 Antibody
- Gene:
- ITGAE NIH gene
- Name:
- integrin subunit alpha E
- Previous symbol:
- -
- Synonyms:
- CD103, HUMINAE
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-09
- Date modifiied:
- 2016-10-11
Related products to: CD103 Antibody
Related articles to: CD103 Antibody
- Preeclampsia is a multifactorial pregnancy complication characterized by hypertension and immune dysregulation, which can lead to adverse maternal and fetal outcomes. Decidual immune cells are critical for pregnancy homeostasis, yet their functional abnormalities and mechanisms in preeclampsia remain poorly understood. Herein, we sorted decidua immune cells from preeclampsia patients for single-cell RNA sequencing to characterize cellular composition and functional heterogeneity. We delineated the immune cell landscape of the decidua in preeclampsia. A hallmark of decidual immune microenvironment in preeclampsia was the marked augmentation of cytotoxic activity. Both NK and T cells exhibited enhanced cytotoxic activity, characterized by the significant upregulation of cytotoxicity-associated genes. NK cells exhibited a differentiation predisposition toward a unique tissue-resident ITGAECD160 subset with heightened cytotoxic and chemokine gene expression. Cell-cell communication analysis further revealed strengthened interactions between NK cells and macrophages, with macrophage-derived SPP1 signals potentially contributing to the amplification of local cytotoxic responses. Collectively, this study provides a comprehensive single-cell analysis of cytotoxic immune changes at the maternal-fetal interface in preeclampsia, revealing enhanced cytotoxicity that may represent a key pathological mechanism. These insights may inform the development of diagnosis and therapeutic strategies targeting cytotoxic immune dysregulation in PE. - Source: PubMed
Publication date: 2026/04/16
Mu YueliLiu DongHe ZhuoxuWang JulinZhou WenjieChen HongqinZhou ShengpingFeng TingZhou RongLi Hong - - Source: PubMed
Publication date: 2026/02/14
Hu XiangLi Ya-QiLi Qing-GuoMa Yan-LeiPeng Jun-JieCai San-Jun - T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previous studies have examined T cells from the lungs captured via bronchoalveolar lavage (BAL), endobronchial brushings, or biopsies. However, whether these different approaches are capturing distinct T cell phenotypes and/or clonotypes remains unclear. Here, using single cell RNA- and T cell receptor (TCR)-sequencing, we report unique phenotypes and clonotypes of T cells isolated via BAL versus endobronchial brushings in healthy controls (HCs) and allergic asthmatics (AAs). The most significant difference in T cell subset abundance between AAs and HCs was the enrichment of CD4 T helper type 2 (T2) cells when comparing endobronchial brush samples (OR = 20.8, P = 0.004), but not when examining BAL (OR = 1.8, P = 0.38), indicating differences in the T cell subsets captured from the BAL versus airway mucosa. In further support of this observation, comparing the BAL and brush T cells across all subjects revealed an up-regulation of resident-memory T (T) cell markers (i.e. ITGAE, CD69) in brush T cells in both CD4 and CD8 lineages. In contrast, BAL CD8 and CD4 T cells exhibited an enriched type I and II interferon signature compared to brush T cells. We validated these findings by generating an independent cohort from publicly available single cell RNA-sequencing data of BAL and brush T cells. Lastly, leveraging the paired samples from our derivation cohort, we performed TCR repertoire analysis, revealing that brush T cells contained expanded TCR clones that were in low abundance or absent in the BAL. Expanded T cell clones from the brush expressed high levels of T cell markers, suggesting the airway mucosa is enriched for T cells with unique TCR specificity. In sum, sampling T cells via BAL versus airway brushings yielded distinct T cell phenotypes and clonotypes with important implications for future research in lung immunology. - Source: PubMed
Publication date: 2026/01/08
Rahimi Rod ASmith Neal PSelle AmandineBest RoyaMartin SidneyTuttle ElizabethSaid WamiaSamanta NandiniLing Morris FMedoff Benjamin DVillani Alexanda-ChloéLuster Andrew D - CD8 T cells play a critical role in controlling infection. CD103, an integrin composed of αE and β7 subunits, is widely recognized as a cell surface marker for tissue-resident memory T (TRM) cells and tumor-infiltrating lymphocytes (TILs). - Source: PubMed
Publication date: 2025/12/11
Pan XingfeiShi FeihuTang ShanniLiu MeilinPan LiLiang GuikuanLi LuXie HongyanZhao ShanHuang Jun - Breast and colorectal cancer are a major global public health problem. Breast cancer is one of the most common cancers worldwide. Colorectal cancer is the third most common cancer and the second most common cause of tumor death worldwide. Central memory T (TCM) cells are closely related to the development of tumors and important targets for immunotherapy. Therefore, identifying the common signaling molecules of these two diseases in TCM cells can improve our understanding of these diseases and lead to the development of therapies that can be effective for treating both. - Source: PubMed
Publication date: 2025/12/22
Miao PengyuZhou ZhaokaiZhang LingHuang XufengLi ZhengruiWei ShouxinHajdu András