CDC27 Blocking Peptide
- Known as:
- CDC27 Blocking Peptide
- Catalog number:
- BP301-184
- Product Quantity:
- 50 ug
- Category:
- Peptides
- Supplier:
- Beth
- Gene target:
- CDC27 Blocking Peptide
Related genes to: CDC27 Blocking Peptide
- Gene:
- CDC27 NIH gene
- Name:
- cell division cycle 27
- Previous symbol:
- D0S1430E, D17S978E
- Synonyms:
- APC3, ANAPC3, NUC2
- Chromosome:
- 17q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-23
- Date modifiied:
- 2017-12-06
Related products to: CDC27 Blocking Peptide
Related articles to: CDC27 Blocking Peptide
- Lung cancer remains a leading cause of cancer mortality in India, yet its genomic landscape remains understudied. To address this gap, we performed whole-exome sequencing (WES) on tumor and matched blood samples from 47 lung cancer patients [adenocarcinoma (ADC): 30; squamous cell carcinoma (SqCC): 10; and small cell lung cancer (SCLC): 7] to comprehensively analyze somatic mutations across all protein-coding genes. Our analysis revealed novel and recurrent alterations, with being the most recurrently mutated gene, and emerging as the most frequently mutated across subtypes. Shared mutations included and , the latter not previously associated with lung cancer. ADC exhibited the highest mutational diversity, particularly in RTK/MAPK pathway genes (). Notably, mutations were identified in 26.7% of ADC cases, including exon 19 deletions (5 cases), exon 21 missense mutations (2 cases), and exon 20 insertions (3 cases) and a novel exon 20 duplication (p.Ser768_Asp770dup). SqCC showed frequent mutations in and , suggesting a role for epigenetic dysregulation. One SqCC case harbored a rare p.Glu866Gly mutation. SCLC was enriched for (43%) and (14%) mutations, along with alterations in and Importantly, therapeutically actionable mutations were identified in 91.5% patients, including those with NCCN-recommended (25.5%) and FDA-approved off-label drug targets (68.1%). These findings underscore the value of WES in uncovering clinically relevant mutations and support the integration of genomic profiling into precision oncology strategies for Indian lung cancer patients. - Source: PubMed
Publication date: 2025/06/06
D'Souza WendyLokesh K NMahajan NareshMishra RadhaAmirtham UshaRajeev L KKumar Arun - Os odontoideum(OO) is a rare bone malformation at the craniovertebral junction, the presence of which can lead to potential instability of atlantoaxial joints. The cause, prevalence and treatment of OO are still controversial. There are two main theories regarding the pathogenesis of OO: congenital factors and traumatic factors. The congenital hypothesis suggests that the lesion results from segmental defects caused by incomplete fusion of the dens and the axis vertebral body during embryonic development. Our research team previously reported a case series involving three generations of a family affected by OO without a clear history of trauma, suggesting the existence of congenital pathogenic factors for this disease. Based on this, we conducted this study to further explore the pathogenesis of OO. - Source: PubMed
Publication date: 2026/04/14
Tian YinglunGao GuodongFan DongweiXue ShilinGao QiyueZhang ChengXu NanfangWang Shenglin - Non-Coding regions contains genomic remnants called as Pseudogenes. For a long time, pseudogenes have been regarded as non-functional. This study investigates the previously unstudied Pseudogene CDC27P9 role in cervical cancer. Whole RNA-transcriptome profiling was performed from blood samples of n = 10 cervical cancer patients and n = 10 age matched healthy controls. CDC27P9 expression was validated in patient samples using RT-PCR. The putative CDC27P9-encoded protein structure was predicted using ChimeraX 1.9, refined predicted protein using (GROMACS 2022.2) and evaluated by Ramachandran plot. Post docking using (HADDOCK2.4) with parent gene CDC27 and other interacting genes, a 100ns MD Simulation (GROMACS 2022.2) was done. Functional studies done by siRNA-mediated silencing of CDC27P9 in HeLa cells to study Anaphase Promoting Complex/Cyclosome Pathway using RT-PCR. Cell Cycle, Mitochondrial Membrane Potential Loss and Apoptosis, using Flow Cytometry. Cell death and Chromatin Condensation was visualised using Laser Scanning Confocal Microscopy and validated in multimode microplate reader. Transcriptome sequencing revealed CDC27P9 upregulated with logFC = 10.68. RT-PCR validated overexpression of CDC27P9 in cervical cancer patients. Putative CDC27P9-encoded protein had an 93.11% of the residues point to protein structure reliability. Molecular docking and MD simulation showed strongest interactions with CDC27 and CDC20. Silencing of CDC27P9, downregulated CDC27 and Anaphase Promoting Complex/Cyclosome genes UBE2L3, PTTG1, ESPL1. In parallel downregulation of anti-apoptotic gene BCL2 while upregulation of pro-apoptotic BAX was observed. Silencing of CDC27P9 induced cell cycle arrest at S-phase, induces apoptosis and mitochondrial membrane potential loss. Observation of Condensed chromatin structure post silencing was an indicative of apoptotic signalling. Further cell death, growth inhibition and morphology changes was observed. Interestingly, silencing of CDC27P9 in cervical cancer HeLa cells caused downregulation of HPV 18. This study is the first to identify pseudogene CDC27P9 as functional with active transcripts and putative protein‑coding potential. Our findings suggest that CDC27P9 may contribute to cervical cancer progression by modulating APC/C‑mediated cell‑cycle pathways, prevent apoptosis thereby sustains cell survival in cancer cells and could be involved in HPV18-associated cellular pathways. - Source: PubMed
Publication date: 2026/03/24
Antony Edwin Rodrigues FenwickKrishnan DeenaAbbas Hussein HameedRaj Minu Jenifer MichaelSubramani SasikalaLakshman NathishJustin AntonyGovindaraj SangamiRamasamy Sivasamy - Cell division cycle 27 () gene expression is closely associated with the cell cycle and has been implicated in the pathogenesis of congenital heart disease (CHD) in animal models. This study focuses on investigating whether single-nucleotide polymorphisms (SNPs) in the gene are associated with CHD and the cardiac remodeling process in the population of Xinjiang, China. - Source: PubMed
Publication date: 2026/02/12
Yuan TengZhu FengAisan AikebaiMaheshati TunikeLi YunxiaTian RenChen You - Noncystic fibrosis (non-CF) bronchiectasis is a chronic respiratory disease characterized by irreversible bronchial dilation, with an increasing global prevalence and substantial clinical burden. Despite the advances in symptomatic management, the underlying molecular mechanisms remain poorly understood. Transcription factor DP-1 () and cell division cycle protein 27 (), which are implicated in tumorigenesis and cell cycle regulation, have not been explored in bronchiectasis. - Source: PubMed
Publication date: 2025/12/25
Hong Kang-KangLi Guo-ShengHe Rong-QuanHuang Zhi-GuangFeng Yi-ZhiKong Jin-LiangLi Lao-Dong