Ac_ IgA (alpha) hum GLOX
- Known as:
- Ac_ Immunoglobulin A (a) hum GLOX
- Catalog number:
- BI 1007
- Product Quantity:
- 4mg/2ml
- Category:
- -
- Supplier:
- P.A.R.I.S
- Gene target:
- Ac_ IgA (alpha) hum GLOX
Related genes to: Ac_ IgA (alpha) hum GLOX
- Gene:
- A4GNT NIH gene
- Name:
- alpha-1,4-N-acetylglucosaminyltransferase
- Previous symbol:
- -
- Synonyms:
- alpha4GnT
- Chromosome:
- 3q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-12
- Date modifiied:
- 2016-10-05
- Gene:
- ABCB5 NIH gene
- Name:
- ATP binding cassette subfamily B member 5
- Previous symbol:
- -
- Synonyms:
- EST422562, ABCB5beta, ABCB5alpha
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-05
- Gene:
- AGPAT1 NIH gene
- Name:
- 1-acylglycerol-3-phosphate O-acyltransferase 1
- Previous symbol:
- -
- Synonyms:
- LPAAT-alpha
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-07
- Date modifiied:
- 2016-10-05
- Gene:
- AKR1C4 NIH gene
- Name:
- aldo-keto reductase family 1 member C4
- Previous symbol:
- CHDR
- Synonyms:
- DD4, HAKRA, C11, 3-alpha-HSD, CDR, MGC22581
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-26
- Date modifiied:
- 2016-06-03
- Gene:
- ARHGEF6 NIH gene
- Name:
- Rac/Cdc42 guanine nucleotide exchange factor 6
- Previous symbol:
- MRX46
- Synonyms:
- alphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-07-27
- Date modifiied:
- 2016-10-05
Related products to: Ac_ IgA (alpha) hum GLOX
Related articles to: Ac_ IgA (alpha) hum GLOX
- Bioceramic sealers are used for their favorable biocompatibility, yet concerns remain regarding cytotoxicity and genotoxicity when extruded. Recently introduced sealers, C-Root SP (CSP) and BC Sealer Ion Plus (BCIP), incorporate formulations that enhance bioactivity. This study aimed to evaluate and compare the cytotoxicity and genotoxicity of CSP, BCIP, and EndoSequence BC Sealer (ESBC) in human periodontal ligament (hPDL) fibroblasts. - Source: PubMed
Publication date: 2026/09/23
Varkalis MykolasSmoczer CristineAskar MazinYoung LauraFerracciolo JosephPaurazas Susan - This study aimed to investigate the antibacterial activities of the ethanolic leaf extract of Rhodomyrtus tomentosa against Enterococcus faecalis (E. faecalis) and its cytocompatibility to human periodontal ligament (hPDL) cells. - Source: PubMed
Publication date: 2026/09/16
Yu-Nu NaowanPaosen SupakitLethongkam SakkarinVoravuthikunchai SupayangTannukit Sissada - Periodontal organoid research remains underdeveloped, largely due to the lack of standardized fabrication protocols and multicellular constructs capable of reproducing epithelial-mesenchymal interactions relevant to periodontal biology. In particular, it remains unclear whether different spatial assembly strategies influence construct stability, multicellular organization, or early molecular behavior in periodontal three-dimensional (3D) systems. Therefore, this study aimed to develop and compare two different methods for generating dual-lineage 3D periodontal organoid-like constructs using human periodontal ligament cells (hPDL) and human gingival epithelial cells (hGEP). These strategies were selected to compare two biologically and technically distinct spatial configurations: bilayer assembly to partially mimic epithelial-connective tissue compartmentalization, and surface seeding as a simplified fabrication approach with potential advantages for reproducibility and workflow standardization. Both cell types were cultured in different media conditions (CnT-57, DMEM, and a 1:1 CnT-57/DMEM mixture) to determine compatibility for co-culture applications. Cell viability was assessed on days 1, 3, and 7 using the MTS assay. Constructs were produced in hyaluronic acid-based hydrogels using two strategies: Group 1-sequential photopolymerization of hPDL and hGEP layers to generate a bilayer construct; and Group 2-encapsulation of hPDL followed by direct seeding of hGEP onto the construct surface. Viability within constructs was evaluated on days 3 and 7 using the Live/Dead assay. Morphology was monitored using stereomicroscopy on days 0, 1, 3, and 7. Exploratory RNA sequencing was performed on day 7 to characterize transcriptomic profiles. All tested culture media maintained cellular viabilities above 70%, with no statistically significant differences among conditions ( > 0.05), indicating biocompatibility for both cell types. Group 1 exhibited viabilities of 86.54% ± 8.55% and 90.69% ± 7.88% on days 3 and 7, respectively, while Group 2 showed viabilities of 87.00% ± 9.58% and 88.08% ± 9.12%, with no significant intergroup differences ( > 0.05). Morphological analyses demonstrated preservation of construct integrity and progressive interaction between epithelial and mesenchymal compartments. Exploratory RNA sequencing revealed only subtle transcriptomic differences between assembly strategies. In conclusion, both methodologies successfully generated viable and structurally stable dual-lineage periodontal organoid-like constructs within a hyaluronic acid-based matrix. Comparison of these two assembly strategies demonstrates the feasibility of generating reproducible multicellular periodontal 3D models using distinct spatial configurations, establishing a proof-of-concept platform for future optimization toward periodontal disease modeling, regenerative studies, and advanced biofabrication applications. - Source: PubMed
Publication date: 2026/08/03
Matos Luiza de OliveiraSordi Mariane BeatrizBirjandi Anahid AhmadiSharpe Paul ThomasCruz Ariadne Cristiane Cabral - The spatial suppression of a high-probability distractor location (HPDL) acquired through statistical learning critically reduces its attentional priority. The present study conducted four experiments to systematically investigate the mechanisms underlying how this learned suppression generalizes to novel tasks. Specifically, we focused on how generalization is influenced by the priority-enhancing attentional capture of a salient target and the competing demands of a newly introduced suppression process. Following training, Experiments 1 and 2 employed a salient color singleton target to test attentional capture. Experiment 1 reused training stimuli, whereas Experiment 2 introduced novel shapes to determine if the capture effect of novel stimuli would completely override the learned suppression. Experiment 3 introduced a new suppression process to evaluate the impact of competing suppression demands. Finally, Experiment 4 utilized a feature search paradigm as a test task devoid of color singletons to eliminate these interfering factors. The results revealed that the intense capture effect of novel stimuli in Experiment 2 completely masked the generalization. Furthermore, sliding window analyses in Experiments 1 and 3 uncovered a dynamic process where generalization only manifested during the middle of the test phase, indicating a competition between these newly introduced factors and the previously acquired suppression. Conversely, eliminating all interference in Experiment 4 yielded a highly stable and persistent generalization of the HPDL suppression. These findings demonstrate that novel interfering factors drive a dynamic adjustment of the HPDL weight within the priority map, revealing the highly flexible and adaptive nature of human attentional control. - Source: PubMed
Zhao YuanWang YuyingZhang JiafengZhang Xuemin - : Autophagy is a key degradative pathway involved in orthodontic tooth movement. DNA damage-regulated autophagy modulator 1 (DRAM1), a protein that plays a central role in the degradation of autophagic cargo, exhibits differential regulation in human periodontal ligament (hPDL) fibroblasts under compressive force. Single-nucleotide polymorphisms (SNPs) may influence force-induced gene expression. Therefore, this study investigated the impact of DRAM1 SNPs on its expression in hPDL fibroblasts under compression force. : The hPDL sample comprised cells of 59 patients. A physiological compressive strain of 2 g/cm was used to simulate orthodontic tooth movement. Total RNA from hPDL fibroblasts was isolated to determine DRAM1 relative gene expression under loaded conditions and in a physiological control. Furthermore, a genotyping analysis of six SNPs within the gene (rs756534 (G/T), rs2138257 (C/T), rs2176092 (C/T), rs4622329 (A/G), rs10860812 (A/G), and rs4764657 (A/G)) was performed using real-time polymerase chain reaction. expression was com-pared among genotypes of each SNP using an alpha of 5%. Linear regression analysis was then employed to evaluate SNP-SNP interaction. : The relative gene expression was not statistically significantly different ( > 0.05) according to the geno-types. The SNP-SNP interaction did not demonstrate any statistically significant associ-ation either. : gene expression in hPDL fibroblasts under orthodontic compression may not be regulated by the studied intronic SNPs in the gene encoding DRAM1. - Source: PubMed
Publication date: 2026/06/23
Linke RebeccaCalvano Küchler ErikaProff PeterKirschneck ChristianSchröder AgnesBeisel-Memmert Svenja