LSP1
- Known as:
- LSP1
- Catalog number:
- Y214472
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- LSP1
Related genes to: LSP1
- Gene:
- LSP1 NIH gene
- Name:
- lymphocyte specific protein 1
- Previous symbol:
- -
- Synonyms:
- WP34
- Chromosome:
- 11p15.5
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-08
- Date modifiied:
- 2018-05-08
Related products to: LSP1
Related articles to: LSP1
- The overall survival rate of acute myeloid leukemia (AML) remains less than 30%. Metabolic reprogramming of leukemia cells, such as the Warburg effect, enables them to adapt to the microenvironment and thereby develop. Elucidating the landscape of lactate regulation in AML helps clarify the pathogenesis from the perspective of metabolic reprogramming and identify possibilities for optimizing current treatment modalities. - Source: PubMed
Publication date: 2026/03/23
Guo ZhiboZhang WenleiGao ZengliangLi QiGuo DanYue LijuanLiu YutongNi XiaotingFan ShengjinHai Xin - Persistently infected (PI) calves resulting from maternal Bovine viral diarrhea virus (BVDV) infection during early gestation are the main source of viral transmission and pose a serious threat to the sustainable production of herds. PI cattle appear clinically normal, elucidating the molecular-level alterations is critical for understanding their specific characteristics. Moreover, the identification of candidate biomarkers for diagnosing PI cattle will provide valuable insights to support effective strategies for the control and eventual eradication of BVDV. At the same time, few studies have focused on the mothers of PI calves (Trojan dam). - Source: PubMed
Publication date: 2026/03/10
Wang JiahaoChen SiqianLai WanyiFeng XiaoZhao QingyaoMi SiyuanXu ChuangQin TongCao JieYu Ying - Tissue homeostasis is dependent on precise coordination between endocrine organs in response to changes in organism physiology. Secreted circulating factors from adipocytes regulate the behavior of stem cell lineages in peripheral tissues in multiple organisms. In addition to their endocrine roles, Drosophila adipocytes store and secrete amino acid storage proteins throughout development. During the larval feeding period, adipocytes secrete storage proteins into the hemolymph, which are reabsorbed by the adipose tissue during metamorphosis to control adult organ size and fertility. Despite the known functions for storage proteins during the larval stages, their requirement during Drosophila adulthood and reproduction are uncharacterized. We discover that adipocyte-specific knockdown of the storage proteins Larval serum protein 1 (Lsp1) α/β/γ and Larval serum protein 2 (Lsp2) results in a decrease in germline stem cell (GSC) maintenance. We further reveal that decreased GSC number is due to downregulation of Target of Rapamycin (TOR) signaling in GSCs, suggesting compromised amino acid sensing directly in GSCs. We also find that the proteins that mediate storage protein adipocyte reabsorption, Fat body protein 1 (Fbp1) and Fat body protein 2 (Fbp2), are expressed in ovarian follicle cells. Intriguingly, Fbp1 nor Fbp2 appear to be required in follicle cells for GSC maintenance, suggesting undiscovered requirements for amino acid storage proteins in oogenesis. Our results highlight a novel role for Drosophila amino acid storage proteins during adulthood and in regulating tissue stem cell lineages. - Source: PubMed
Publication date: 2026/03/11
Zike Anna BHazen Mekenzi OAbel Madison GGoldstone Eleanor BEisman Robert CWeaver Lesley N - Eukaryotic messenger RNA (mRNA) homeostasis requires precise coordination between synthesis and decay, yet the mechanisms governing this balance in fungal pathogens remain elusive. Here we provide a comprehensive characterization of the Lsm1-7 complex in the cereal pathogen Fusarium graminearum. We show that Lsm1-7 assembles into a conserved hetero-heptameric module that localizes to processing bodies (P-bodies) and is required for fungal growth, virulence, and mycotoxin biosynthesis. Mechanistically, Lsm1-7/Pat1 binds U/A-rich 3' termini of a defined set of transcripts enriched for central metabolism and restrains their 3'-5' decay. Genetic suppressor analyses and mechanistic dissection identify two parallel decay routes antagonized by Lsm1-7, including the exosome recruited by the uridyltransferase Cid1 and the Ski-exosome complex mediated by the newly identified scaffold protein Lsp1. Moreover, loss of Lsm1-7 elicits a compensatory transcriptional response involving the Rpd3L (Sin3) histone deacetylase complex, in which elevated histone H4 acetylation at affected loci partially restores transcript output. Together, our results define an integrated cytoplasmic-nuclear regulatory axis in F. graminearum that couples 3'-end protection to chromatin-based transcriptional buffering to maintain mRNA homeostasis. While Lsp1 appears lineage-adapted, the underlying logic may reflect a broader principle of gene-expression buffering that supports fungal fitness and pathogenicity. - Source: PubMed
Ren YiyiYan JiayueHan XingminXu ChenghuiGuo MeilingWang XuanLiu ChaoLogrieco Antonio FJin YongfengMa ZhonghuaChen Yun - Human neural progenitor cells (hNPCs) show promise in slowing retinal degeneration and are currently being tested in clinical trials for retinitis pigmentosa (RP). However, the long-term fate of grafted hNPCs and their interaction with host retinal cells remain unclear. Here, we used single-cell transcriptomics to investigate temporal gene expression changes in grafted hNPCs and host retinal cells following subretinal injection into a rodent model of RP, revealing dynamic transcriptomic changes in the degenerative retinal environment. Grafted hNPCs primarily differentiate into an astroglial phenotype and mature over time, contributing to photoreceptor protection through trophic factor secretion, metabolic modulation, suppression of apoptosis, oxidative stress, and inflammation, alongside extracellular matrix remodeling. CellChat analysis revealed a decline in intercellular signaling and communication strength over time, correlating with weakened hNPC-host interactions. These findings suggest that enhancing trophic factor support, particularly MANF, and improving the host retinal environment are critical for sustaining long-term vision preservation. - Source: PubMed
Publication date: 2026/03/06
Shahin SabaBell ShaughnLu BinBanerjee SomanshuSwarup VivekXu HuiChetsawang JasonRamirez StephanyAlfaro Jorge SLaperle AlexanderSvendsen SoshanaSvendsen Clive NWang Shaomei