CDC42EP3
- Known as:
- CDC42EP3
- Catalog number:
- Y214430
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- CDC42EP3
Related genes to: CDC42EP3
- Gene:
- CDC42EP3 NIH gene
- Name:
- CDC42 effector protein 3
- Previous symbol:
- -
- Synonyms:
- CEP3, UB1, BORG2
- Chromosome:
- 2p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-27
- Date modifiied:
- 2016-10-05
Related products to: CDC42EP3
Related articles to: CDC42EP3
- Ovarian cancer (OC) remains the most lethal gynecologic malignancy, primarily due to late-stage diagnosis resulting from nonspecific early symptoms. This study aims to identify novel genetic targets and elucidate the underlying mechanisms driving OC progression by integrating multi-omics datasets. - Source: PubMed
Publication date: 2026/01/21
Feng YueLiu Guoyan - Bronchopulmonary dysplasia (BPD) is a prevalent respiratory disease in premature infants and is accompanied by impaired lung function, increased infection risk, and other long-term complications. This study aimed to elucidate the molecular mechanisms of BPD, especially mitophagy. - Source: PubMed
Publication date: 2025/08/09
Li ChenshuaiWang YaleiWang XinyingLi Yali - Antisocial behaviour (ASB) involves persistent irresponsible, delinquent activities violating rights and safety of others. A meta-analysis of genome-wide association studies revealed significant genetic associations with ASB, yet their brain expression patterns and behavioural relevance remain unclear. Our investigation of fifteen genes associated with ASB examined their biological role and distribution across tissues, integrating post-mortem brain sample data from the Allen-Human-Brain Atlas and the Genotype-Tissue Expression project. We found that these genes were differentially expressed in the brain, particularly in regions like the cerebellum, putamen, and caudate, and were notably downregulated in the pancreas. Single cell type expression analysis revealed that ASB-associated genes had strong correlations with ductal and endothelial cells in the pancreas, indicating a possible metabolic influence on ASB. Certain genes like NTN1, SMAD5, NCAM2, and CDC42EP3 displayed specificity for cognitive terms including chronic pain, heart rate, and aphasia. These expression patterns aligned with neurocognitive domains related to thinking, and learning, distress, motor skills, as determined by fMRI analysis. This study connects specific brain gene expression with potential genetic and metabolic factors in ASB, offering novel insights into its biological basis and possible interdisciplinary approaches to understanding and addressing aggressive behaviours. - Source: PubMed
Publication date: 2025/04/10
Rokicki JaroslavCampbell Megan Lvan der Meer DennisSartorius Alina ITesli NataliaJahołkowski PiotrShadrin AlexeyAndreassen OleWestlye Lars TQuintana Daniel SHaukvik Unn K - Septins are cytoskeletal filament-forming proteins that typically associate with membranes and perform critical functions in a variety of cellular processes. Septins often colocalize with actin and microtubule structures, yet our understanding of all the ways that septins contribute mechanistically to actin- and microtubule-based functions is incomplete. The Cdc42 effector protein Cdc42EP3 (also known as BORG2) promotes septin localization to actin structures in vivo, but little else is known about how Cdc42EP3 influences the interactions of septins and F-actin. Here, using purified components, we show that Cdc42EP3 binds directly to septins, actin filaments, and actin monomers. Moreover, septin-bound Cdc42EP3 accelerates actin filament polymerization. Thus, Cdc42EP3 is not merely a factor that crosslinks septins and F-actin, but one that promotes the formation of actin polymers along septin scaffolds. - Source: PubMed
Publication date: 2025/02/18
Tomasso Meagan RMehetre Prajakta DNagarajan PriyashreeRavi RoshniByrnett JenniferBrinckman EricMagliozzi JosephGoode Bruce LPadrick Shae B - Pancreatic cancer (PC) is a devastating human malignancy with a poor survival outcome (5-year survival less than 10 %). In recent years, the regulatory roles of long non-coding RNAs (lncRNAs) in various types of cancers have been widely reported. Based on bioinformatics analysis, LINC01857 is shown to be highly expressed in PC tissue. Nevertheless, the role of LINC01857 in PC is limitedly reported. Hence, this study aimed to explore the effects of lncRNA LINC01857 on PC cell process and the related mechanism. - Source: PubMed
Publication date: 2024/09/25
Zhang Jian-XinShen Yan-BinMa Dan-DanLi Zhong-HuZhang Zhi-YongJin Wei-Dong