EML5
- Known as:
- EML5
- Catalog number:
- Y214390
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- EML5
Related genes to: EML5
- Gene:
- EML5 NIH gene
- Name:
- EMAP like 5
- Previous symbol:
- -
- Synonyms:
- HuEMAP-2, EMAP-2
- Chromosome:
- 14q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-17
- Date modifiied:
- 2019-04-16
Related products to: EML5
Echinoderm microtubule-associated protein-like 5,EMAP-5,EMAP-like protein 5,Eml5,Rat,Rattus norvegicusEchinoderm microtubule-associated protein-like 5,EMAP-5,EML5,Homo sapiens,HumanEchinoderm microtubule-associated protein-like 5,EMAP-5,Eml5,Mouse,Mus musculusELISA Kit FOR Echinoderm microtubule-associated protein-like 5; organism: Mouse; gene name: Eml5EML3 Gene echinoderm microtubule associated protein like 3EML5 AntibodyEML5 3&_39;UTR Lenti-reporter-Luc VectorEML5 AntibodyEML5 antibodyEML5 Antibody (OAEB00528)EML5 Antibody - middle region (ARP70192_P050)EML5 antibody Polyclonal Antibodies Primary antibodiesEML5 antibody Polyclonal Antibody Host: GoatEML5 Antibody.EML5 Gene echinoderm microtubule associated protein like 5 Related articles to: EML5
- Identifying patients most likely to benefit from immune checkpoint inhibitors (ICIs) remains a significant challenge in advanced melanoma. We evaluated the association between tumor somatic mutations and clinical outcomes, focusing on relapse-free survival (RFS) and overall survival (OS) in locoregionally advanced melanoma patients treated with neoadjuvant ipilimumab. Tumor specimens and matched peripheral blood samples from 22 patients underwent whole-exome sequencing (WES) to identify non-synonymous somatic mutations. Tumor mutational burden (TMB) was quantified, and specific mutations were analyzed for associations with survival outcomes. The analysis revealed a mutational landscape dominated by single-nucleotide missense mutations with a median TMB of 11.4 mutations/MB. and mutations were detected in 73% of patients and exhibited mutual exclusivity and concurrence patterns ( < 0.05). Positional clustering identified and as key contributors to melanoma (FDR -value < 0.05). Log-rank analysis indicated that mutations in , , , , , , and were associated with shorter survival outcomes (RFS or OS). The associations remained significant in both univariate and multivariable Cox regression models adjusted for TMB. These genes can be broadly grouped into functional categories relevant to tumor progression and immune modulation. In applying multiple testing correction, none maintained statistical significance, indicating that these findings should be interpreted as exploratory and require validation in independent cohorts. This study identified tumor genomic alterations associated with clinical outcomes in melanoma patients treated with neoadjuvant ipilimumab, suggesting their potential role in anti-tumor immunity. These findings warrant further investigation in larger cohorts and across other ICIs in melanoma and other malignancies. - Source: PubMed
Publication date: 2026/03/19
Khaksar Mohammad AliEljilany IslamYassine IbrahimYu XiaoqingTeer Jamie KConejo-Garcia Jose RLyons MaureenLaFramboise WilliamTarhini Ahmad A - Langya chickens, a Chinese indigenous breed, exhibit rich genetic resources but relatively low egg production performance. To investigate the genetic basis of egg production traits, we performed low-depth genome resequencing of 1,183 Langya hens and evaluated six phenotypic traits, including age at first egg (AFE), egg number at different laying stages-EN1 (from first egg to 26 weeks), EN2 (27-36 weeks), EN3 (37-43 weeks), total egg number at 43 weeks (E43), and maximal clutch length (MCL). Genetic parameter analysis revealed that MCL exhibited high heritability (0.42) and strong genetic correlations with both egg production and AFE, suggesting its potential as a more effective selection indicator for egg production traits. Genome-wide association studies identified a total of 245 SNPs associated with these traits. Notably, a 6.58 Mb region on chromosome 5 (GGA5, 40.03-46.61 Mb) was enriched for multiple traits and in strong linkage disequilibrium. Candidate genes in this core region, including TSHR, GTF2A1, DIO2, STON2, NRXN3, KCNK10, EML5, and FOXN3, were implicated in transcriptional regulation, thyroid hormone signaling, neuroendocrine modulation, and ovarian function. Additional trait-specific candidate genes, such as ATG2B for EN2, FMNL1 for EN1/EN2, TDP1 for E43, and TPMT for MCL, were also identified. Functional enrichment analyses highlighted pathways related to cellular processes, lipid metabolism, and signal transduction. These findings provide genomic insights into the molecular mechanisms underlying egg production traits and offer valuable candidate genes for marker-assisted breeding in Langya chickens. - Source: PubMed
Publication date: 2026/01/04
Zhang HongruiFu YuanjieWang YanlinYin SijingJiang YunliangSun YiKang Li - The central biological clock governs numerous facets of mammalian physiology, including sleep, metabolism, and immune system regulation. Understanding gene regulatory relationships is crucial for unravelling the mechanisms that underlie various cellular biological processes. While it is possible to infer circadian gene regulatory relationships from time-series gene expression data, relying solely on correlation-based inference may not provide sufficient information about causation. Moreover, gene expression data often have high dimensions but a limited number of observations, posing challenges in their analysis. - Source: PubMed
Publication date: 2023/09/26
Hu ShuwenJing YiLi TaoWang You-GanLiu ZhenyuGao JingTian Yu-Chu - Pressure injury management requires reliable identification of critical colonisation due to lack of infection signs. Our research group previously proposed the mRNAs natriuretic peptide B (Nppb), integrin subunit beta 6 (Itgb6), copine 4 (Cpne4), echinoderm microtubule-associated protein like 5, and intersectin 1 as candidate markers in pooled exudates of critically colonised wounds. However, it is unclear whether mRNAs or proteins of the candidate genes would be suitable as biomarkers in fresh exudate. Therefore, this study aimed to evaluate the validity of the mRNAs and proteins as fresh exudate markers for critical colonisation. Three wound models of normal healing, critical colonisation, and infection were created in rats. Fresh swab-collected exudates were collected, and mRNA and protein expression levels were measured. In the fresh wound exudates, the detection frequency of Itgb6 tended to decrease in the critically colonised and infected wounds (P = .067), and those of Cpne4 and Nppb tended to be lower in the infected wounds than in the normal healing and critically colonised wounds (P = .006 and .067, respectively). In contrast, there was no difference in protein expression in the exudates. This study suggests that Itgb6 mRNA in fresh exudates is a promising biomarker for critical colonisation. - Source: PubMed
Publication date: 2022/10/28
Takizawa ChihiroMinematsu TakeoNakagami GojiroKitamura AyaKoudounas SofoklisKunimitsu MaoSanada Hiromi - This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in ( ), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull's fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; = 222) and, in general, AI breeding to Nellore cows (41%; = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and will characterize the role of EML5 in spermatogenesis. - Source: PubMed
Publication date: 2022/04/05
Nogueira EriklisTirpák FilipHamilton Lauren EZigo MichalKerns KarlSutovsky MiriamKim JaeWooVolkmann DietrichJovine LucaTaylor Jeremy FSchnabel Robert DSutovsky Peter