MTHFR
- Known as:
- MTHFR
- Catalog number:
- Y214378
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- MTHFR
Related genes to: MTHFR
- Gene:
- MTHFR NIH gene
- Name:
- methylenetetrahydrofolate reductase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p36.22
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-15
- Date modifiied:
- 2019-04-23
Related products to: MTHFR
Related articles to: MTHFR
- The tetra-primer amplification refractory mutation system (T-ARMS) PCR assay is a cost-effective and rapid method for SNP genotyping. The methylenetetrahydrofolate reductase (MTHFR) c.1286 A > C (rs1801131) polymorphism can influence MTHFR enzyme activity and homocysteine levels. While its independent clinical impact remains a subject of debate, it is frequently screened in thrombophilia panels, particularly in the context of compound heterozygosity. - Source: PubMed
Publication date: 2026/05/16
Alqosaibi AmanyRasheed Akram Husain Rehman SyedTombuloglu HuseyinAltwayan RehamAlhusil AbdulrahmanAwadh TaghreedOzdemir Mehmet - - Source: PubMed
Publication date: 2026/05/14
Zhao YouliWang QianHe YanjunWang XiaxiaPan Yunyan - Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and obesity are associated with glucose metabolism dysregulation. This study aimed to investigate the individual and joint effects of MTHFR gene polymorphisms and pre-pregnancy body mass index (pre-BMI) status on postpartum abnormal glucose tolerance (PAGT) risk among women with gestational diabetes mellitus (GDM). - Source: PubMed
Publication date: 2026/05/12
Gu ChunmingLai KefengLiu YanWu WeixiangZhang XiaodanZhang ZhiliMai QiongdanZheng XianhuaLuo Mingyong - Malaria, primarily caused by , remains a critical global health challenge, particularly in sub-Saharan Africa. Genetic factors such as angiotensin-converting enzyme (ACE) I/D polymorphism have been implicated in influencing malaria severity and outcomes. We report the case of a 40-year-old woman from Seychelles, residing in Ivory Coast, who developed severe malaria complicated by thrombosis. Laboratory findings revealed hyperparasitemia, acute kidney injury, and metabolic acidosis. Genetic testing through real time PCR identified the ACE I/D polymorphism, along with other thrombophilic variants such as MTHFR C677T and A1298C, suggesting a potential role in clinical course. This case aims to contribute to the debate about the role of ACE polymorphisms in malaria severity. Comprehensive studies are warranted to explore the genetic landscape in malaria-endemic regions and its implications for personalized treatment strategies. - Source: PubMed
Publication date: 2026/05/06
Pisapia RaffaellaPomicino AndreaMinei GiuseppinaIadevito IsabellaPerrella Alessandro - Methotrexate (MTX) is a long-standing drug used to treat leukemia (at high doses to inhibit DNA/RNA synthesis) and rheumatoid arthritis (at low doses for anti-inflammatory effects). Its characteristic narrow therapeutic range, in terms of efficacy and safety associated with MTX, are important factors to consider when deciding whether to prescribe it. A major challenge in its use is interindividual variability which is largely attributed to germline genetic polymorphisms in genes encoding proteins that control the pharmacokinetics or pharmacodynamics of MTX. - Source: PubMed
Publication date: 2026/05/09
Esperón PatriciaVital MarceloGiletti Andrea