PLGF
- Known as:
- PLGF
- Catalog number:
- Y214368
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- PLGF
Related genes to: PLGF
- Gene:
- PGF NIH gene
- Name:
- placental growth factor
- Previous symbol:
- PGFL
- Synonyms:
- PLGF, PlGF-2, PlGF, SHGC-10760, D12S1900, PIGF
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-14
- Date modifiied:
- 2016-05-20
Related products to: PLGF
Anti-human PlGF (#178 G10), Biotin, Source: Monoclonal Murine, MABAnti-human PlGF (#178/G10), Biotin, Source: Monoclonal Murine, MABAnti-human PlGF (#331 H12), Source: Monoclonal Murine, MABAnti-human PlGF (#331/H12), Source: Monoclonal Murine, MABAnti-human PlGF (AG) (nat.), Source: Polyclonal Rabbit, PABAnti-human PlGF (MAB), Source: Monoclonal Murine, MABAnti-human PlGF (Prot.A) (nat.), Source: Polyclonal Rabbit, PABAnti-human PlGF (Prot.A) (nat.), Source: Polyclonal Rabbit, PABAnti-human PlGF AntibodyAnti-human PlGF antibodyAnti-human PlGF, Source: Polyclonal Rabbit, PABAnti-human PlGF, Source: Polyclonal Rabbit, PABAnti-Human PlGF-1Anti-Human PlGF-1Anti-Human PlGF-1 Related articles to: PLGF
- Serum metabolomics is a powerful approach for characterizing the systemic biochemical changes accompanying reproductive transitions in livestock. A hormone-based protocol, CIDR-PGFα, is used to drive Kazak ewes through a defined sequence of reproductive stages: the LP (luteal phase, early stage), LDP (luteolysis, middle stage), and OES (estrus, late stage when the ewe exhibits estrus). However, the serum metabolic dynamics during these transitions remain uncharacterized. - Source: PubMed
Publication date: 2026/07/31
Yaseen UllahWang JingleiHou MengqiKang JiaLi MingshanWu XiangRuge YanZhao Zongsheng - While GnRH induces the preovulatory LH surge, PGF2α triggers luteolysis and uterine contraction. Therefore, Lecirelin-Cloprostenol combination given at the end of the TAI protocol may improve fertility in cows. Eight studies evaluated a novel Lecirelin-Cloprostenol (GPG) fixed-dose combination for ovulation and fertility in Nelore cattle subjected to timed artificial insemination (TAI) protocols. Initial experiments (Exp. 1, n = 28) showed GPG and GnRH induced earlier ovulation than PGF. In Exp. 2 (n = 25) and Exp. 4 (n = 17), the GPG protocol reduced the dispersion of ovulation timing compared to GnRH alone (Bartlett's test, P < 0.05). In Exp. 3, the GPG group had lower intrafollicular estradiol (P = 0.04) and higher PTGS2 gene expression (P = 0.05) compared to the GnRH group. Fertility outcomes varied: GPG tended (P = 0.1) to increase pregnancy per artificial insemination (P/AI) in postpartum cows (Exp. 5, n = 326) and improved ovulation rates when estradiol cypionate (EC) was used (Exp. 6, n = 17). While a large field study (Exp. 7, n = 948) showed no overall P/AI difference when the GPG treatment was given following estradiol cypionate. Finally, GPG and GnRH had similar P/AI (P = 0.3) in non-estrus cows (Exp. 8, n = 1692) compared to GnRH. In conclusion, GPG upregulated PTGS2 expression and decreased intrafollicular E2 concentrations in the ovulatory follicle relative to GnRH, providing a mechanistic basis for the improved ovulatory synchrony observed in GPG-treated cows. While the GPG formulation consistently reduced the dispersion of ovulation timing across experiments, effects on P/AI were marginal in the present study. - Source: PubMed
Publication date: 2026/08/10
Pfeifer Luiz Francisco MachadoHurtado Cintia Batistade Souza Vanessa LemosBarbosa Ingrid PedraçaSilva Samira Alves de SouzaPegoraro Lígia Margareth CantarelliSilva Renata Reis daMoraes Fabiane Pereira deCastro Natalia Avila deAndrade André CascalhoRovani Monique TomazeleGasperin Bernardo Garziera - Drug-induced liver injury remains a major clinical challenge due to the lack of effective therapeutic options. extract (PO), derived from the traditional medicinal and edible plant , has long been used in folk practices in forms such as herbal soups and tea infusions. However, its protective effect against acetaminophen (APAP)-induced liver injury has not yet been investigated. - Source: PubMed
Publication date: 2026/07/29
Qin HuanghuiChen RunxiaoShi YingLi CaibinBin YimingZeng ZhaomingDeng BinXiao YuboLi Lanyu - Chronic inflammation and cyclooxygenase (COX)-2-mediated prostanoid signaling contribute to melanoma progression, yet their modulation by natural products remains poorly defined. We examined the effects of dogwood fruit extracts-Japanese cornel () and two European cultivars ('Uholok', 'Yantarnyi')-on temporal prostanoid dynamics in A375 (primary tumor-derived) and MeWo (metastasis-derived) mela-noma cells. Dynamic changes rather than static levels were modeled using GAMLSS or zero-inflated Gamma models to assess time, cell line, cornel type, and dose effects. Untreated A375 cells showed time-dependent increases in PGE, PGF, thromboxane B, and 13,14-dihydro-PGE, consistent with inducible COX-2 activation, whereas MeWo cells maintained consistently high prostanoid levels, reflecting constitutive COX-2 expression. extracts modulated these trajectories in a cell- and dose-dependent manner. In A375, low concentrations allowed prostanoid accumulation, while higher doses flattened or reversed these increases; Japanese cornel produced the strongest inhibition, whereas European cultivars showed weaker or cultivar-specific effects. MeWo cells were less responsive, with significant changes emerging only at higher doses. PGD and 6-keto-PGF remained largely unchanged, indicating selective targeting of COX-2-dependent prostanoids. Extracts also reduced accumulation of downstream prostanoids, including 15-deoxy-Δ,-PGJ and 13,14-dihydro-PGE, particularly in A375 cells. These differences highlight a stronger susceptibility of early-stage melanoma to phytochemical intervention and support cultivar-dependent bioactivity linked to phytochemical composition. In summary, extracts selectively attenuate time-dependent trajectories of tumor-promoting prostanoids-most effectively with Japanese cornel-while sparing homeostatic mediators, warranting further investigation on their potential for melanoma chemoprevention or adjunctive therapy. - Source: PubMed
Publication date: 2026/08/03
Lewandowski ŁukaszKrzystek-Korpacka MałgorzataMykhailova DariaKorbecka MartynaBryk MichałFleszar MariuszFortuna PaulinaKucharska Alicja ZSozański TomaszZalejska-Fiolka JolantaMosna KarolinaSzewczak WioletaBednarz-Misa Iwona - Enzymatic deamidation using protein-glutamine glutaminases (PGs) is a promising method for improving the solubility, foaming properties, and emulsifying properties of plant proteins. This study compared the deamidation of various plant proteins using PGs from (PGC), (PGB), and sp. (PGF) and examined the effects on the foaming and emulsifying properties of sunflower and oat proteins. PGB produced the largest increases in protein solubility, though PGF usually gave the highest maximal degree of deamidation (DD(max)). For oat protein, all PGs reduced maximum foam volume (V(max)), but PGC and PGB doubled foam half-time (t). For sunflower protein, PGB reduced V(max), while PGC increased t by up to 17.5-fold. Thus, different PGs affect techno-functional properties distinctly, reflecting different substrate specificities. Improvements in solubility, foaming, and emulsifying properties are not dependent on achieving the highest DD(max). Expanding the range of available PGs would allow for better matching to plant substrates and enhance industrial applicability. - Source: PubMed
Publication date: 2026/07/23
Roth NicoleEbinger DianeHorstmann GudrunFischer Lutz