XPNPEP1
- Known as:
- XPNPEP1
- Catalog number:
- Y214318
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- XPNPEP1
Related genes to: XPNPEP1
- Gene:
- XPNPEP1 NIH gene
- Name:
- X-prolyl aminopeptidase 1
- Previous symbol:
- XPNPEP, XPNPEPL1, XPNPEPL
- Synonyms:
- -
- Chromosome:
- 10q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-15
- Date modifiied:
- 2016-10-05
Related products to: XPNPEP1
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- The causal relationships between the gut microbiota and prostate cancer, prostatitis, and benign prostatic hyperplasia remain uncertain. We intend to identify the causal connections between the gut microbiota and prostatic diseases and investigate the potential mechanisms involved. - Source: PubMed
Publication date: 2024/11/23
Liu TianruiYang FeixiangWang ZhigeMei YunyunLi HaoWang KunZhang XiangyuChen YidingZhang YangMeng Jialin - The genome-wide association studies (GWAS) of lung disease and lung function indices suffer from challenges to be transformed into clinical interventions, due to a lack of knowledge on the molecular mechanism underlying the GWAS associations. A proteome-wide association study (PWAS) was first performed to identify candidate proteins by integrating two independent largest protein quantitative trait loci datasets of plasma proteins and four large-scale GWAS summary statistics of lung function indices (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and peak expiratory flow (PEF)), followed by enrichment analysis to reveal the underlying biological processes and pathways. Then, with a discovery dataset, we conducted Mendelian randomization (MR) and Bayesian colocalization analyses to select potentially causal proteins, followed by a replicated MR analysis with an independent dataset. Mediation analysis was also performed to explore the possible mediating role of these indices on the association between proteins and two common lung diseases (chronic obstructive pulmonary disease, COPD and Asthma). We finally prioritized the potential drug targets. A total of 210 protein-lung function index associations were identified by PWAS, and were significantly enriched in the pulmonary fibrosis and lung tissue repair. Subsequent MR and colocalization analysis identified 59 causal protein-index pairs, among which 42 pairs were replicated. Further mediation analysis identified 3 potential pathways from proteins to COPD or asthma mediated by FEV1/FVC. The mediated proportion ranges from 68.4% to 82.7%. Notably, 24 proteins were reported as druggable targets in Drug Gene Interaction Database, among which 8 were reported to interact with drugs, including , , , , , , , and . Our study identified the crucial plasma proteins causally associated with lung functions and highlighted potential mediating mechanism underlying the effect of proteins on common lung diseases. These findings may have an important insight into pathogenesis and possible future therapies of lung disorders. - Source: PubMed
Publication date: 2025/03/01
Zhao YansongShen LujiaYan RanLiu LuGuo PingLiu ShuaiChen YingxuanYuan ZhongshangGong WeimingJi Jiadong - Genome-wide association studies (GWAS) have identified numerous variants associated with psychiatric disorders. However, it remains largely unknown on how GWAS risk variants contribute to psychiatric disorders. - Source: PubMed
Publication date: 2024/11/02
Gong WeimingGuo PingLiu LuYan RanLiu ShuaiWang ShukangXue FuzhongZhou XiangSun XiubinYuan Zhongshang - infection is the primary cause of the chronic infectious illness tuberculosis (TB). Long non-coding RNAs (lncRNAs) are functional RNA molecules that cannot be translated into proteins and play a crucial role in regulating the immune system's innate and adaptive responses. It has been demonstrated that the dysregulation of lncRNA expression is associated with various human diseases. However, the mechanism underlying the involvement of so many lncRNAs in the immune response to TB infection remains unclear. The objective of our current study was to identify a number of significantly differentially expressed lncRNAs in peripheral blood mononuclear cells (PBMCs) from TB patients and to select the most indicative lncRNAs as potential biomarkers for active pulmonary tuberculosis. - Source: PubMed
Publication date: 2023/12/14
Li GuoliFeng ZhelongSong HonghuanWang YajingZhu LimeiLi Yan - Lung adenocarcinoma (LUAD) is a common lung cancer with a poor prognosis under standard chemotherapy. Hypoxia is a crucial factor in the development of solid tumors, and hypoxia-related genes (HRGs) are closely associated with the proliferation of LUAD cells. - Source: PubMed
Publication date: 2023/08/07
Liu LiuHan LinaDong LeiHe ZihaoGao KaiChen XuGuo Jin-ChengZhao Yi