Calponin 3 _ CNN3
- Known as:
- Calponin 3 _ CNN3
- Catalog number:
- Y214295
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Calponin 3 _ CNN3
Related genes to: Calponin 3 _ CNN3
- Gene:
- CNN3 NIH gene
- Name:
- calponin 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-16
- Date modifiied:
- 2016-10-05
Related products to: Calponin 3 _ CNN3
Acidic Calponin LysateActopaxin,Alpha-parvin,Calponin-like integrin-linked kinase-binding protein,CH-ILKBP,Homo sapiens,Human,Matrix-remodeling-associated protein 2,MXRA2,PARVAAnti - Mouse, Calponin Clone CALPAnti - Mouse, Calponin Clone CALPAnti - Mouse, Calponin Clone CALPanti-Acidic Calponinanti-Acidic Calponinanti-Acidic Calponin type: Primary antibodies host: Mouseanti-Calponin (2F5-1H4)anti-Calponin (3C7-2A6)anti-Calponin (3C7-2A6)anti-Calponin (3C7-2A6)anti-Calponin (3C7-2A6) type: Primary antibodies host: Mouseanti-Calponin (CP-19)anti-Calponin (CP-19) Related articles to: Calponin 3 _ CNN3
- Angiogenesis plays a pivotal role in driving tumour progression, including tumour growth, local invasion, and distant metastasis. Calponin 3 (CNN3) belongs to the actin-binding protein family and has been shown to be aberrantly expressed in osteosarcoma specimens, but its exact role in the regulation of angiogenesis remains unknown. This study aimed to investigate the function and underlying mechanism of CNN3 in osteosarcoma angiogenesis. - Source: PubMed
Publication date: 2026/02/13
Sun DongDai FeiXiang BinqingWang HengTao HaiyanZhang ShuaiTao XiaoliangZhu XianjieLuo FeiSong Lei - To address the current challenges of low single-sensor recognition accuracy for coal and rock cutting states, redundant channel feature responses, and poor performance in traditional neural network models, this paper proposes a new multi-sensor coal and rock cutting state recognition model based on a graph neural network (GNN). This model, consisting of a feature encoder, an information exchange module, and a feature decoder, enhances the communication of feature responses between filters within the same layer, thereby improving feature capture and reducing channel redundancy. Comparative, ablation, and noise-resistance experiments on multi-sensor datasets validate the effectiveness, versatility, and robustness of the proposed model. Experimental results show that compared to the baseline models, CNN3, ResNet, and DenseNet achieve improvements of 2.47%, 2.78%, and 1.50%, respectively. With the addition of the ACI block, the ResNet model achieves the best noise-resistance performance, achieving an accuracy of 93.27% even in 6 dB noise, demonstrating excellent robustness. Embedded deployment experiments further confirmed that the proposed model maintains an inference time of less than 216.1 ms/window on the NVIDIA Jetson Nano, meeting the real-time requirements of actual industrial scenarios and demonstrating its broad application prospects in resource-constrained underground working environments. - Source: PubMed
Publication date: 2025/11/07
Jin ZhixinCheng JieCao WenyanWang HongweiZhang JiaxinLiu ZepingWang HaoranLi Jianzhong - Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their cellular functions and isoform-specific roles remain poorly understood. By depleting the three CNN isoforms (calponin-1 [CNN1], calponin-2 [CNN2], and calponin-3 [CNN3]) individually and collectively from U2OS cells, we show that CNNs are not negative regulators of myosin II, as previously suggested. Instead, we reveal that CNNs are critical regulators of stress fiber organization that control the distribution of actin filament cross-linker, α-actinin, along actomyosin bundles. Consequently, loss of CNNs dramatically reduced stress fiber thickness, increased their fragility, and impaired cell migration. Notably, we also identify isoform-specific roles for CNNs. The non-muscle CNN isoform CNN3 displays rapid turnover in stress fibers, enabling their dynamic remodeling, whereas the smooth-muscle isoform CNN1 exhibits stable association with stress fibers, supporting the formation of "smooth-muscle-like" thick and static actomyosin bundles. Our findings highlight CNNs as key regulators of stress fiber architecture, cell migration, and morphogenesis and provide new insights into the functional diversity of smooth-muscle and non-muscle CNN isoforms. - Source: PubMed
Publication date: 2025/11/25
Kokate Shrikant BOshin Afsana TChua Xiang LeChastney MeganBiswas ParijatKogan KonstantinTomberg TeemuIvaska JohannaLappalainen Pekka - 5-Fluorouracil and Oxaliplatin form backbone of colorectal cancer, yet resistance limits their efficacy. Understanding the molecular determinants of sensitivity and resistance may guide potential biomarker discovery and inform drug repurposing strategies. - Source: PubMed
Abdullah M - Epstein-Barr Virus (EBV), a potent viral carcinogen, plays a crucial role in the development of various malignancies. Among its proteins, EBV nuclear antigen-1 (EBNA1) stands out for its ability to modulate gene expression. In this study, we explored the impact of EBNA1 on the expression patterns of four cellular genes-Derlin1, ZEB1, CNN3, and PSMD10-in HeLa cells. - Source: PubMed
Publication date: 2025/08/06
Alipour Amir HosseinHashemi Seyed Mohammad AliGharahkhani FatemehKatanchi AlirezaFarhadi AliSarvari Jamal