PDPN
- Known as:
- PDPN
- Catalog number:
- Y214274
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- PDPN
Related genes to: PDPN
- Gene:
- PDPN NIH gene
- Name:
- podoplanin
- Previous symbol:
- -
- Synonyms:
- T1A-2, Gp38, aggrus, GP40, PA2.26
- Chromosome:
- 1p36.21
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-08
- Date modifiied:
- 2014-11-19
Related products to: PDPN
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- Painful diabetic peripheral neuropathy (PDPN) remains a serious complication of diabetes mellitus (DM). Recent clinical trials have demonstrated promising outcomes for pilavapadin (LX9211), an orally administered selective, potent inhibitor of adapter protein-2-associated kinase 1 (AAK1) and vixotrigine, a broad spectrum voltage-gated sodium channels (Navs) inhibitor. Their beneficial role was reflected in improved average daily pain (ADP) score and Patient Global Impression of Change (PGIC). Gamma-aminobutyric acid (GABA) receptor agonism has yielded favourable outcomes in preliminary studies. Experimental studies have further expanded the spectrum of potential agents, therapeutic targets and mechanisms in PDPN. Some of potential therapeutic approaches include chemokine suppression (CCR2/CCR5 or CXCR1/2 inhibition) and transient receptor potential vanilloid 1 (TRPV1) pathway suppression. Impaired mitochondrial function in PDPN is now being discussed and the inhibition of poly (adenosine diphosphate [ADP]-ribose) polymerase 1(PARP1), a mitochondrial enzyme responsible for deoxyribonucleic acid (DNA) repair is emerging. Local treatments have also been examined in animal models, such as resiniferatoxin. Limited evidence exists regarding the therapeutic potential of antidiabetic agents, glucagon-like peptide-1 receptor agonists (GLP-1RAs), being most widely studied in experimental settings. Future large clinical trials are now required to confirm the efficacy of novel promising agents and to delineate further potential favourable effects of antidiabetic agents in clinical settings. - Source: PubMed
Publication date: 2026/03/31
Panou TheodorosPapanas NikolaosKempler Peter - Psoriasis is a T cell-mediated inflammatory skin disease, and biologics have demonstrated promising efficacy. However, some patients remain dissatisfied with early therapeutic outcomes. Immune checkpoint molecules on T cells play critical roles in psoriasis pathogenesis, yet their impact on therapeutic response remains unclear. This study aimed to identify predictive markers for the early therapeutic efficacy of ixekizumab in psoriasis patients. - Source: PubMed
Publication date: 2026/03/27
Yang NanChen ZeyuJiang YuxiongCai JiangluyiCui LianWang YuanyuanLin SuyangWu LingDu QianGu JunGong YuYu QianShi Yuling - Although pregabalin is a first-line therapy for painful diabetic polyneuropathy (PDPN), its optimal dose-response relationship remains unclear. We conducted a network meta-analysis to evaluate the efficacy and safety of fixed pregabalin dosages in PDPN patients. - Source: PubMed
Publication date: 2026/04/13
Kwon DoyunJung Hee-JaeNam JunhoKim JonghaeJeon EonjuKwak Sanggyu - This study determines the phenotypic and functional characteristics that define distinct fibroblast-like synoviocyte (FLS) populations in rheumatoid arthritis (RA) vs psoriatic arthritis (PsA). - Source: PubMed
Publication date: 2026/04/10
Tynan ÓrlaBrugman Aenea A ISmith ConorCanavan MaryO'Rourke Aoife MFloudas AchilleasAnton DumitruWade SiobhánSundanum SoniaFletcher Jean MOrr CarlVeale Douglas JFearon Ursula - Lymphatic metastasis is strongly associated with poor prognosis. Although the chemokine receptor CCR7 is a well-established promoter of lymphatic dissemination, its prognostic relevance remains weak. We show that tumour cell plasticity, defined by podoplanin (PDPN)-expression and promoted by hypoxia, intersects with CCR7 function in triple-negative breast cancer (TNBC). - Source: PubMed
Publication date: 2026/04/09
Wang ZhiIngebriktsen Lise MartineBekkhus ToveMa LyusongQueiro-Palou AntonioShi WenyangBazioti AnastasiaPanagias Michail AngelosVigorelli MartinaLehrstrand Joakim HarryRing SarahDimberg AnnaWik ElisabethHoivik Erling AndreFuxe JonasUlvmar Maria H