PDPN
- Known as:
- PDPN
- Catalog number:
- Y214274
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- PDPN
Related genes to: PDPN
- Gene:
- PDPN NIH gene
- Name:
- podoplanin
- Previous symbol:
- -
- Synonyms:
- T1A-2, Gp38, aggrus, GP40, PA2.26
- Chromosome:
- 1p36.21
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-08
- Date modifiied:
- 2014-11-19
Related products to: PDPN
Anserine Podoplanin Elisa Kit (PDPN)Anserine anti - Podoplanin Elisa Kit (PDPN)anti-PDPN Podoplanin (5E2)anti-PDPN Podoplanin (5E2) type: Primary antibodies host: MouseAnti-PDPN (5E2), Mouse Monoclonal to PDPN, Isotype IgG2b, Host Mouseanti-PDPN / Podoplanin (5E2)Antibodies: PDPN HOST: Goat Clonality: pAbAntigens PDPN, 99-207aa, Human, His-tagged, Recombinant, E.coliBovine anti-Podoplanin Elisa Kit (PDPN)Bovine PDPN ELISA KitBovine Podoplanin (PDPN) ELISA KitBovine Podoplanin (PDPN)ELISA KitBovine Podoplanin (PDPN)ELISA KitBovine Podoplanin ELISA , PDPNBovine Podoplanin ELISA , PDPN Related articles to: PDPN
- The engineering of a 3D lymphatic collecting vessel has been of recent interest due to the lack of treatments for lymphatic valve disruptions. While oscillatory shear stress has been shown to regulate lymphatic collecting vessel morphogenesis, its effect in the context of physiologically relevant extracellular matrix remains elusive. In this study, we used a microfluidic device to elucidate the effect of oscillatory shear stress on human lymphatic endothelial cells cultured on dopamine-modified hyaluronic acid or fibronectin. Here, we show that hyaluronic acid can synergistically enhance mechanoresponsive morphological changes, activate cytoskeleton localization, induce nuclear expression of key mechanosensitive markers (PROX1 and FOXC2), amplify mechanotransduction pathways (VE-CAD and mTORC1), and downregulate capillary lymphatic markers (PDPN and LYVE-1). These results highlight the potential of hyaluronic acid-based materials for the generation of 2D and 3D lymphatic collecting vessel models. - Source: PubMed
Publication date: 2026/09/04
Lightsey N KeilanyFluskey GraceCruz-Gonzalez BrendaFan FeiSaha SanjoyHall EvaHanjaya-Putra Donny - The meningeal lymphatic system contributes to hematoma resolution and neurological recovery after intracerebral hemorrhage (ICH). We previously demonstrated that intraperitoneal cilostazol administration promotes dural lymphatic growth and enhances clearance of intracerebrally injected red blood cells; however, the antiplatelet effects of cilostazol raise safety concerns in ICH, potentially limiting clinical translation. Here, we evaluated whether oral cilostazol at clinical-equivalent doses in mice enhances dural lymphatic function and improves outcomes after ICH. - Source: PubMed
Publication date: 2026/09/03
Lan Chen-KaiChen Wan-RuHsieh Yung ChiaLin Tze-YenHsu Shao-ChunJiang Zi-RouChen Shih-PinJiang DanyeMcCullough Louise DAronowski JaroslawTsai Li-KaiTsai Hsin-HsiChang Che-Feng - Natural killer (NK) cell-based immunotherapies are promising for cancer treatment due to their ability to eliminate cancer cells independently of antigen presentation and "off-the-shelf" utility. However, molecular determinants governing tumor susceptibility to NK cytotoxicity remain incompletely understood. Here we employ CRISPR activation (CRISPRa) screening to identify cancer cell surface regulators of NK killing. Using a surfaceome-focused library, we screen human and murine cancer cell lines co-cultured with NK cells, identifying known and novel ligands modulating NK cytotoxicity. Screens reveal established factors including CD43 and previously uncharacterized regulators CD44, PDPN, and Siglec-1/CD169. Validation with orthogonal approaches confirm that disruption of these factors alters NK killing susceptibility in vitro and in humanized mouse models. Mechanistically, we find that CD43-mediated NK resistance operates independently of its proposed interaction with Siglec-7, and that targeting CD43 on NK cells or CAR T cells substantially enhances cytotoxic activity against leukemia. These results establish gain-of-function surfaceome screening as a powerful tool for identifying therapeutic targets for NK cell-based immunotherapy. - Source: PubMed
Publication date: 2026/08/06
Dinesh Ravi KWang XiaotongMohammad Imran AGunasekaran PariStiklioraitis KostasVillafuerte Jeremy RRao AnirudhHernandez-Lopez Rogelio ASunwoo John BCong Le - Peripheral neuropathic pain (PNP) is a chronic condition that often requires long-term treatment. In 2025, the Neuropathic Pain Special Interest Group (NeuPSIG) updated its recommendations for treatment of neuropathic pain based on data from double-blind, randomized controlled trials (RCTs) with a duration of ≥ 3 weeks. To complement the existing body of evidence, we reviewed the long-term efficacy/safety of NeuPSIG-recommended treatments for PNP. - Source: PubMed
Publication date: 2026/08/31
Eerdekens Mariëlle HBoth CharlotteFreitas Rita L - Diabetic peripheral neuropathy (DPN) affects up to 50% of individuals with diabetes mellitus and remains one of the most prevalent and disabling chronic complications of the disease. Approximately one-third develop painful DPN (pDPN), characterized by spontaneous burning pain, electric-shock sensations, allodynia, and hyperalgesia, all of which significantly impair quality of life. Classical mechanisms, including hyperglycemia-driven oxidative stress, mitochondrial dysfunction, microvascular insufficiency, ion-channel dysregulation, and neuroinflammatory activation, explain the structural and functional deterioration of peripheral nerves but do not fully account for the emergence of painful phenotypes. In this narrative review, we aim to provide an overview of the current understanding of pDPN, focusing on how peripheral metabolic and neuroimmune disturbances interact with central nervous system plasticity to produce chronic pain, and highlight emerging evidence that mechanistic endotypes may guide more precise, individualized therapies. - Source: PubMed
Publication date: 2026/08/27
Ignacy PawełGut-Misiaga MartynaGil AleksandraKwiendacz HannaGumprecht JanuszLip Gregory Y HAlam UazmanNabrdalik Katarzyna