FEM1A _ APRAP
- Known as:
- FEM1A _ APRAP
- Catalog number:
- Y214235
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- FEM1A _ APRAP
Related genes to: FEM1A _ APRAP
- Gene:
- FEM1A NIH gene
- Name:
- fem-1 homolog A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-10-08
- Date modifiied:
- 2016-03-18
- Gene:
- FEM1C NIH gene
- Name:
- fem-1 homolog C
- Previous symbol:
- -
- Synonyms:
- KIAA1785, EUROIMAGE686608, EUROIMAGE783647, FEM1A
- Chromosome:
- 5q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-10-08
- Date modifiied:
- 2016-10-05
Related products to: FEM1A _ APRAP
anti-FEM1Aanti-FEM1Aanti-FEM1Aanti-FEM1AAnti-Human FEM1A, Rabbit PolyclonalAnti-Human FEM1A, Rabbit Polyclonal affinity purified IgGAntibodies: FEM1A _ APRAP HOST: Goat Clonality: pAbBos taurus,Bovine,FEM1a,FEM1A,FEM1-alpha,Protein fem-1 homolog ABovine fem-1 homolog a (C. elegans) (FEM1A) ELISA kit, Species Bovine, Sample Type serum, plasmaBovine Protein fem-1 homolog A(FEM1A) ELISA kitBovine Protein fem-1 homolog A(FEM1A) ELISA kit SpeciesBovineELISA Kit FOR Protein fem-1 homolog A; organism: Human; gene name: FEM1AELISA Kit FOR Protein fem-1 homolog A; organism: Rat; gene name: Fem1aEPRAP,FEM1a,FEM1A,FEM1-alpha,Homo sapiens,Human,Prostaglandin E receptor 4-associated protein,Protein fem-1 homolog AFECD7 Gene - Related articles to: FEM1A _ APRAP
- The Pacific white shrimp, (), is an important aquaculture species, yet the molecular mechanisms underlying its sex differentiation and gonadal development remain poorly understood. A deeper understanding of these processes is critical for advancing broodstock quality and enabling unisex breeding strategies. While previous studies have focused on gene expression differences between females and males, structural differences in transcriptomic regulation between sexes have been largely overlooked. Here, we present a comprehensive full-length transcriptome analysis of testis and ovary, identifying 830 and 690 novel genes, respectively, and over 6000 new isoforms. Notably, we discovered extensive alternative splicing (AS) events, with the cartilage oligomeric matrix protein-like gene exhibiting over 300 AS isoforms in the ovary compared to only 2 in the testis, suggesting a potential role in ovarian development. Furthermore, sex-determining genes such as , , and were found to produce AS isoforms exclusively in ovarian tissue. We also identified three germ cell development-associated genes-, , and -that undergo distinct AS events in gonadal tissues, leading to sex-specific structural domain alterations. These findings highlight the complexity of AS-mediated post-transcriptional regulation in and provide novel insights into the molecular mechanisms governing sex differentiation and gonadal development. - Source: PubMed
Publication date: 2025/06/19
Wang YouyanYu YangWang YueLi Fuhua - The Fem-1 (Feminization-1) gene, encoding an intracellular protein with conserved ankyrin repeat motifs, has been proven to play a key role in sex differentiation in Caenorhabditis elegans. In the present study, three members of the Fem-1 gene family (designating Fem-1A, Fem-1B, and Fem-1C, respectively) were cloned and characterized in the redclaw crayfish, Cherax quadricarinatus. Sequence analysis showed that all three Fem-1 genes contained the highly conserved ankyrin repeat motifs with variant repeat numbers, which shared similarity with other reported crustaceans. In addition, a phylogenetic tree revealed that the Fem-1 proteins from C. quadricarinatus were clustered with the crustacean Fem-1 homologs, and had the closest evolutionary relationship with Eriocheir sinensis. Quantitative real-time PCR (qRT-PCR) results demonstrated that Fem-1B exhibited a significant higher expression abundance in the ovary than in other tissues. In addition, a regular mRNA expression pattern of the Fem-1B gene appeared in the reproductive cycle of ovarian development. Furthermore, RNA interference experiments were employed to investigate the role of Fem-1B in ovarian development. Moreover, knockdown of Fem-1B by RNAi decreased the expression of VTG in the ovaries and hepatopancreas. In summary, this study pointed out that Fem-1B was involved in the sex differentiation process through regulating VTG expression in C. quadricarinatus, and provided new insights into the role of Fem-1B in ovary development. - Source: PubMed
Publication date: 2021/11/30
Zheng JianboChen LeranJia YongyiChi MeiliLi FeiCheng ShunLiu ShiliLiu YinuoGu Zhimin - Nowadays, due to increasing carbon dioxide released, water acidification poses a series of serious impacts on aquatic organisms. To evaluate the effects of water acidification on crustaceans, we focused on the Chinese mitten crab Eriocheir sinensis, which is a spawning migration and farmed species in China. Based on histological and oocyte transparent liquid observation, we found that the acidified environment significantly delayed the ovarian maturation of E. sinensis. Moreover, RNA-seq was applied to obtain gene expression profile from the crab's gills and ovaries in response to acidified environment. Compared with control groups, a total of 5471 differentially expressed genes (DEGs) were identified in acidified gills and 485 DEGs were identified in acidified ovaries. Enrichment analysis indicated that some pathways also responded to the acidified environment, such as PI3K-Akt signaling pathway, Chemokine signaling pathway, apoptosis, and toll-like receptor signaling pathway. Subsequently, some DEGs involved in immune response (ALF, Cathepsin A, HSP70, HSP90, and catalase) and ovarian maturation (Cyclin B, Fem-1a, Fem-1b, and Fem-1c) were selected to further validate the influence of water acidification on gene expression by qRT-PCR. The results showed that the expression level of immune-related genes was significantly increased to response to the water acidification, while the ovarian maturation-related genes were significantly decreased. Overall, our data suggested that E. sinensis was sensitive to the reduced pH. This comparative transcriptome also provides valuable molecular information on the mechanisms of the crustaceans responding to acidified environment. - Source: PubMed
Publication date: 2021/06/19
Luo Bi-YunQian Hong-LiJiang Hu-ChengXiong Xin-YiYe Bao-QingLiu XueGuo Zi-QiMa Ke-Yi - C-degrons play critical roles in targeting the receptor proteins of Cullin-RING E3 ligase complexes to initiate protein degradation. FEM1 proteins, including FEM1A, FEM1B, and FEM1C, act as the receptors to specifically recognize Arg/C-degrons to enable CRL2-mediated protein turnover. Very few substrates have been identified for FEM1B, except CDK5R1. We found that CRL2 also recognizes the C-degron of an SMCR8 isoform, and uncovered the recognition of SMCR8 by FEM1B through presenting the structure of FEM1B bound to SMCR8. Our work provides insights into the role of CRL2 in regulating the lifetime of SMCR8, a critical autophagy regulator. - Source: PubMed
Publication date: 2021/04/20
Zhao ShidongRu WenwenChen XinyanLiao ShanhuiZhu ZhongliangZhang JiahaiXu Chao - Proteome integrity depends on the ubiquitin-proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-degrons) that are recognized by specific cullin-RING ubiquitin ligases (CRLs) for proteasomal degradation. FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive. Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C. Together with biochemical and mutagenesis studies, we provide a framework for understanding molecular recognition of the Arg/C-degron by the FEM family of proteins. - Source: PubMed
Publication date: 2021/01/04
Yan XiaojieWang XiaoluLi YaoZhou MengqiLi YanjunSong LiliMi WenyiMin JinrongDong Cheng