BMAL1 _ ARNTL
- Known as:
- BMAL1 _ ARNTL
- Catalog number:
- Y214226
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- BMAL1 _ ARNTL
Related genes to: BMAL1 _ ARNTL
- Gene:
- ARNTL NIH gene
- Name:
- aryl hydrocarbon receptor nuclear translocator like
- Previous symbol:
- -
- Synonyms:
- MOP3, JAP3, BMAL1, PASD3, bHLHe5
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-06
- Date modifiied:
- 2017-08-18
Related products to: BMAL1 _ ARNTL
Related articles to: BMAL1 _ ARNTL
- Chronic kidney disease (CKD) is driven by inflammation, fibrosis, and metabolic dysfunction. While circadian rhythm dysregulation is well documented in chronic disorders, its specific impact on CKD pathogenesis remains elusive. - Source: PubMed
Publication date: 2026/09/06
Li Xiao-QianCheng LeiChen Tian-FenMa Yi-NuoLi Xiao-HuiFu Ting-YuXiao JingZhao Zhan-Zheng - Although individual traits related to metabolic dysfunction-associated steatotic liver disease (MASLD) have been investigated through large-scale genome-wide association studies (GWASs), the shared genetic susceptibility across these traits remains unclear. We therefore conducted a multivariate GWAS of key MASLD-related traits to elucidate their common genetic architecture. We applied genomic structural equation modeling to model a latent genetic factor (MASLD-F) underlying genetically correlated MASLD-related traits, leveraging their GWAS-derived genetic correlations. We then performed functional annotations, including fine-mapping, transcriptome-wide association study, and cell- and tissue-type-specific enrichment analyses, and conducted Mendelian randomization analyses to identify modifiable risk factors. Our multivariate MASLD-F GWAS identified 50 independent variants across 48 genomic loci. Transcriptomic imputation identified several MASLD-F-associated genes, including ARNTL, NPC1, BTBD10, VDAC2, TSKU, SFMBT1, and ABHD17C. We observed significant enrichment of MASLD-F-related genetic signals predominantly in brain tissues, pancreatic islets, and the adrenal gland. Additionally, six modifiable risk factors and four modifiable protective factors for MASLD-F were identified. These findings reveal a complex shared genetic architecture underlying MASLD components, thereby expanding our understanding of disease pathogenesis and providing novel insights for precision medicine and public health interventions. - Source: PubMed
Dong HaoLi YufengDing QiangZhang MiaoxinGu ShuaipengLiu Mei - Circadian and sleep-wake dysregulation have been implicated in episode recurrence and clinical heterogeneity in bipolar disorder (BD), supporting peripheral circadian markers as candidates for further investigation. This study examined the peripheral expression of selected circadian rhythm-related gene mRNAs and antisense long non-coding RNAs (lncRNAs), alongside corresponding serum protein levels and self-report-based rhythm phenotyping, in euthymic patients with BD. Sixty euthymic patients with BD (20 BD-1, 20 BD-2, and 20 with antidepressant-associated hypo/manic switch [ASHH], treated as an exploratory group) and 20 healthy controls were enrolled. Euthymia was verified by HAM-D < 7 and YMRS < 6, and chronotype and rhythm phenotypes were assessed using the MEQ, SRM-5, and BRIAN. Morning fasting blood was collected (08:00-10:00) with the morning medication dose withheld; because sampling was confined to a single morning window, the reported values represent morning transcript abundance rather than circadian rhythmicity, amplitude, or phase position. Three core clock gene mRNAs () and two antisense lncRNAs () were quantified by qRT-PCR (2^-ΔΔCt, β-actin reference), and serum CIART, CRY1, PER2, and ARNTL proteins were measured by ELISA. Between-group comparisons used nonparametric tests (Mann-Whitney U; Kruskal-Wallis H with Bonferroni post hoc), and correlations used Spearman's coefficient with Benjamini-Hochberg FDR correction. Compared with healthy controls, patients showed statistically significantly higher expression of the lncRNAs (r = 0,57) and (r = 0,49) and the mRNAs (r = 0,35) and (r = 0,29), all p ≤ 0,007, whereas mRNA did not differ (p = 0,654). In exploratory subgroup analyses, differences were concentrated in BD-2 and ASHH: BD-2 showed the highest expression and BD-1 the lowest, with BD-1 not differing from controls for any marker. Serum protein levels did not differ between groups or subgroups, and MEQ, BRIAN, and SRM-5 scores did not differ; however, a sensitivity analysis excluding shift workers revealed a chronotype difference masked in the full sample. Across 174 correlational tests, none survived FDR correction (lowest q = 0,063); nominal uncorrected associations are reported as preliminary only. In euthymic BD, peripheral expression of selected circadian rhythm-related markers-particularly the antisense lncRNAs and and the mRNAs of and - differed from healthy controls, whereas corresponding serum protein levels and behavioral rhythm phenotypes did not. This divergence across measurement levels can be considered a substantive finding, and the subgroup patterns are exploratory and hypothesis-generating. Longitudinal, episode-inclusive, and subtype-stratified studies incorporating objective circadian phase markers and repeated sampling are needed to establish the significance of peripheral transcript-level differences in BD.HIGHLIGHTS Peripheral circadian gene mRNAs and antisense lncRNAs are profiled in euthymic bipolar subtypes. and lncRNAs and and mRNAs are higher in patients than controls.Exploratory analyses: transcript differences concentrate in BD-2 and ASHH; not BD-1.Serum CIART, CRY1, PER2, and ARNTL protein levels by ELISA do not differ by group.Behavioral rhythm scores do not differ; correlations do not survive FDR correction. - Source: PubMed
Publication date: 2026/09/04
Gümüşlü Ağcabay AslıhanDemir BahadırKorkmaz MuratYumrutaş PınarSancaktar MuhammetElboğa GülçinBülbül FeridunAltındağ Abdurrahman - Successful embryo development transpires far before fertilization inside the meticulously regulated microenvironment of the ovarian follicle. Increasing data indicates that circadian regulatory systems influence several processes that define oocyte competence, including mitochondrial activity, oxidative balance, meiotic development, and cellular metabolism. Brain and muscle ARNT-like protein 1 (BMAL1), an essential transcription factor in circadian regulation, has garnered significant interest due to its crucial involvement in ovarian physiology and reproductive function. Dysregulated BMAL1 signaling has been linked to compromised folliculogenesis, diminished steroidogenesis, mitochondrial dysfunction, elevated oxidative stress, and irregularities in meiotic spindle organization, all of which may negatively impact oocyte quality and early embryo development. Recent experimental and clinical findings indicate that results of assisted reproduction may be influenced by circadian disruption, sleep problems, obesity, ageing, and metabolic dysfunction. - Source: PubMed
Publication date: 2026/08/21
Voros CharalamposZagorianakou NektariaMakrydimas StylianosChatzinikolaou FotiosPapadimas GeorgiosKoulakmanidis Aristotelis MariosThomakos NikolaosAntsaklis PanagiotisDaskalakis GeorgiosMakrydimas George - While circadian disturbances are commonly comorbid with schizophrenia (SCZ), whether deficits in clock genes can induce SCZ-like behaviors in mice remains poorly understood. Brain and muscle Arnt-like protein 1 (Bmal1, also known as Mop3 or Arntl), a core circadian clock gene, is implicated in the regulation of circadian rhythms, and its single nucleotide polymorphism rs1982350 has been linked to the pathogenesis of SCZ. - Source: PubMed
Yao Yi-QinGuo Bo-WeiXu Zhi-YiWang CunHong HaoChen Zhi-GangTang Su-Su