TRPV2
- Known as:
- TRPV2
- Catalog number:
- Y214209
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- TRPV2
Related genes to: TRPV2
- Gene:
- TRPV2 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 2
- Previous symbol:
- -
- Synonyms:
- VRL, VRL-1, VRL1
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-29
- Date modifiied:
- 2016-01-28
Related products to: TRPV2
Related articles to: TRPV2
- Following their domestication, chickens were translocated around the world to novel environments. Through a combination of natural and artificial selection, chickens adapted to these local conditions, creating significant genetic diversity across populations worldwide. Studying this diversity in the context of local environmental conditions may offer insights into mechanisms of adaptation to environmental stressors. In this study, we analyzed genomic data from the Chicken Genomic Diversity Consortium, applying multiple statistical approaches, including fixation index (F), nucleotide diversity (π), Tajima’s D, and runs of homozygosity (ROH), to identify selective sweeps among indigenous chickens from Afghanistan, China, Indonesia, Iran and Pakistan, compared with White Leghorn chickens. We identified sweeps in 14 genes related to heat tolerance, associated with relevant gene ontology (GO) terms and located within ROH regions. These genes, such as , , , , , , , , , , , , , , and play crucial roles in calcium signaling pathways, thermal sensation, and the plasticity of neurodevelopmental processes. These findings illustrate the significant role of selection in shaping genomic differentiation across chicken populations and provide insights into the genetic basis of adaptation to environmental stressors. - Source: PubMed
Publication date: 2026/04/07
Hosseinzadeh SevdaRafat Seyed AbbasJavanmard ArashHasanpur KarimBardou PhilippeCharles MathieuKlopp ChristopheSmith Adrian LFiddaman Steven R - Skeletal muscle responds to stressors such as exercise and muscle injury by adaptive remodelling. The resilience of skeletal muscle involves not only mature muscle fibres but also the adjacent muscle satellite cells (MuSCs). We previously found that transient receptor potential vanilloid type 2 (TRPV2) is expressed in MuSCs and is essential for MuSC proliferation and activation in MuSC-specific conditional knockout mice. These mice show no mechanical-load-induced muscle hypertrophy and delayed injury-induced muscle regeneration. The effect of TRPV2 on Ca signalling during early myogenesis is unknown; however, here, we demonstrate that tranilast, an inhibitor of TRPV2, suppressed IPR-derived Ca oscillations in early myogenesis. The addition of adenovirus (Ad)-TRPV2 or Ad-Cre recombinase to floxed-TRPV2 cells modulated TRPV2 expression, and demonstrated the TRPV2 dependence of IPR and MEF2c expression, nuclear translocation of MEF2c, and Ca oscillations. These findings indicate that TRPV2 regulates intracellular Ca signalling during early myogenesis and highlight its potential as a target for the prevention and treatment of muscle disorders. - Source: PubMed
Publication date: 2026/03/25
Chen YanzhuKatanosaka KimiakiKatanosaka Yuki - Degenerative Joint Disease (DJD) is a form of highly prevalent osteoarthritis in humans and animals, including cats, which causes significant pain and hypersensitivity. Despite its prevalence, the mechanisms underlying the DJD-associated pain in cats are poorly understood. While transient receptor potential (TRP) ion channels are expressed in the dorsal root ganglia (DRG) and are implicated in osteoarthritis pain (e.g., through Artemin/GFRA3-mediated changes to TRPV1 and TRPA1 electrical properties), there is currently only indirect evidence of TRP ion channel expression in the feline DRG. This study aims to address this knowledge gap. - Source: PubMed
Publication date: 2026/03/17
Wheeler Joshua JTamamoto-Mochizuki ChieGruen Margaret ELascelles B Duncan XMishra Santosh K - Transient receptor potential vanilloid 2 (TRPV2) is a non-selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a novel small-molecule activator of TRPV2. - Source: PubMed
Publication date: 2026/03/30
Leipe AndreaRocereta Julia APumroy Ruth ALeffler AndreasSchaefer MichaelMoiseenkova-Bell VeraHill Kerstin - Platelets are generated by megakaryocytes (MKs) in the bone marrow. A key step in this process involves the extension of MK protrusions across the sinusoidal vessel barrier through tiny endothelial pores. While the MK cell body remains in the marrow stroma, proplatelets elongate in the bloodstream. Transendothelial migration and elongation imposes strong deformation and stretching on the plasma membrane. - Source: PubMed
Publication date: 2026/03/27
Boscher JulieDevaux MarineRuch LaurieGuinard InesOllinger MathildeWeber JosianeStrassel CatherineLéon Catherine