EGLN3
- Known as:
- EGLN3
- Catalog number:
- Y214170
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- EGLN3
Related genes to: EGLN3
- Gene:
- EGLN3 NIH gene
- Name:
- egl-9 family hypoxia inducible factor 3
- Previous symbol:
- -
- Synonyms:
- PHD3, HIFPH3
- Chromosome:
- 14q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-21
- Date modifiied:
- 2016-10-05
Related products to: EGLN3
Anti-human HIF-prolyl Hydroxylase 3 (PHD3 EGLN3) IgG, aff pureAntibodies: EGLN3 HOST: Goat Clonality: pAbAntigens EGLN3, 1-239aa, Human, His tag, E.coli. RecombinantEgl nine homolog 3 (EGLN3) polyclonal antibodyEgl nine homolog 3, mitochondrial,Egln3,HIF-PH3,HIF-prolyl hydroxylase 3,HPH-3,Hypoxia-inducible factor prolyl hydroxylase 3,Rat,Rattus norvegicus,Sm20,SM-20Egl nine homolog 3,EGLN3,HIF-PH3,HIF-prolyl hydroxylase 3,Homo sapiens,HPH-1,HPH-3,Human,Hypoxia-inducible factor prolyl hydroxylase 3,PHD3,Prolyl hydroxylase domain-containing protein 3Egl nine homolog 3,Egln3,HIF-PH3,HIF-prolyl hydroxylase 3,HPH-3,Hypoxia-inducible factor prolyl hydroxylase 3,Mouse,Mus musculus,SM-20EGLN1 Gene egl nine homolog 1 (C. elegans)EGLN3 PHD3 antibody Ab host: GoatEGLN3 AntibodyEGLN3 (Human) Recombinant Protein (P01)EGLN3 (Human) Recombinant Protein (Q01)EGLN3 (Human) Recombinant Protein (Q01)EGLN3 / PHD3 antibody Host RabbitEGLN3 / PHD3 antibody Isotype IgG Host Rabbit Related articles to: EGLN3
- Diabetic foot ulcer (DFU) is characterized by persistent inflammation, metabolic dysfunction, and impaired angiogenesis, leading to refractory chronic wounds. Here, we report an adhesive, metformin-loaded (1.0 mM) polyethylene glycol (PEG) based hydrogel (i.e., PEG/Met), constructed from equal volumes of PEG-SG (20 wt.%) and PEG-NH (20 wt.%), to regulate macrophage polarization and metabolism in DFU. Density functional theory (DFT) calculations and infrared spectra confirmed its crosslinking, yielding a homogeneous PEG network with strong tissue adhesion (31.4 ± 8.6 kPa) and sustained drug release till seven days (total release: 86.8 ± 0.6%). In a rat DFU model, the PEG/Met significantly accelerated wound closure (wound recovery: 91.9 ± 3.4%, which was 1.96-fold to the control), collagen deposition, M2-like macrophage infiltration, and neovascularization. Under lipopolysaccharides (LPS) or Staphylococcal protein A (SpA) induced pro-inflammatory stimulation, the PEG/Met suppressed glycolytic flux, reduced glucose uptake and consumption, yet increased adenosine triphosphate (ATP) production and restored oxygen consumption, indicating a shift from glycolysis toward oxidative phosphorylation (OXPHOS). Likewise, the PEG/Met restored mitochondrial membrane potential, reduced reactive oxygen species (ROS) accumulation, increased Egln3 expression, and decreased Hif-1α and IL-1β levels, thereby alleviating Hif-1α-driven inflammatory signaling. Pharmacologic inhibition of OXPHOS with rotenone reversed PEG/Met-induced M2 polarization and reactivated pro-inflammatory gene expression, confirming the intact mitochondrial respiration for its immunoregulatory effects. This PEG/Met hydrogel functioned as both an adhesive, drug-delivery platform and immune-metabolic modulator, effectively reprogramming macrophage phenotype and mitochondrial metabolism, which held substantial promise as a localized therapy for DFU and other chronic wounds. STATEMENT OF SIGNIFICANCE: Diabetic foot ulcer (DFU) is a leading cause of limb loss worldwide, as traditional dressings only passively cover wounds without resolving chronic inflammation caused by metabolic and immune disorders. Here, we fabricated a polyethylene glycol (PEG) based adhesive hydrogel for local metformin delivery (PEG/Met), which achieved strong tissue adhesion, biodegradability, and sustained drug release. The hydrogel reprogrammed macrophage metabolism from glycolysis to oxidative phosphorylation, thereby improving mitochondrial function, decreasing mitochondrial reactive oxygen species, enhancing Egln3-mediated Hif-1α ubiquitination, and alleviating IL-1β-mediated inflammation. This hydrogel created a pro-angiogenic microenvironment to accelerate DFU healing in vivo. By linking the clinically approved metformin, this adhesive hydrogel platform offered a translational strategy for treating DFU and other chronic wounds. - Source: PubMed
Publication date: 2026/04/21
Chen XuehuiZou ZhenyuWei PengfeiZhang XueyingLi YunhuanJing WeiZhao BoLiu YuchenHuang YiqianWu Xiaowei - To screen key genes related to efferocytosis in osteoarthritis (OA) based on bioinformatics and machine learning methods, and explore their diagnostic value, immune microenvironment characteristics, and potential therapeutic targets of traditional Chinese medicines (TCM). - Source: PubMed
Xiang KelinZhang XiaoyuLi ZhengpengXu ZhiweiLiu SujieChai Yuan - Childhood obesity is a major global public-health challenge. Insulin resistance (IR) is a critical driver of later cardiometabolic alterations. A comprehensive understanding of the molecular mechanisms underlying the initial development of childhood IR is essential for timely prevention and intervention. In this study, we aimed to assess the association between IR and blood DNA methylation in a longitudinal study from childhood into adolescence. - Source: PubMed
Publication date: 2026/02/24
Anguita-Ruiz AugustoTorres-Martos ÁlvaroBustos-Aibar MireiaSetó-Llorens AdriàRuiz-Ojeda Francisco JavierMoreno Luis AGil ÁngelGil-Campos MercedesBueno GloriaLeis RosauraAlcalá-Fdez JesúsAguilera Concepción M - Tissue-derived extracellular vesicles (Ti-EVs) play a crucial role in tumour progression, but their value as differential diagnostic markers for various renal cell carcinoma (RCC) subtypes remains uncertain. Through analysis of paired tumour and normal tissues, along with their corresponding Ti-EVs, we identified NEAT1 and MMP15 as markers for papillary RCC (pRCC); DSG2 and AC026888.1 for chromophobe RCC (chRCC); NDUFA4L2, SERPINA1, VEGFA, EGLN3, CPE and C6orf223 for low-grade clear cell RCC (low-grade ccRCC); and NDUFA4L2, APOC1, TGFBI and LINC00887 for high-grade ccRCC (high-grade ccRCC). In an external validation cohort, an area under the curve (AUC) of 0.922 for low-grade ccRCC detection and 0.874 for high-grade ccRCC detection was achieved, respectively, using urinary EVs. Furthermore, integrating single-cell sequencing data revealed that SERPINA1 and VEGFA in low-grade ccRCC, and APOC1 and TGFBI in high-grade ccRCC, were derived from tumour-associated macrophages, whereas NDUFA4L2 originated from cancer cells in both low- and high-grade ccRCC. - Source: PubMed
Wu XinruiZhou JialeJiang ChenChen WenjinPeng ZehongWu TianyangGe YangDu XinxingHu CongWu XiaorongHuang JiweiZhang JinCui XingangXue WeiChen YonghuiDong Liang - Exosomes and lactylation modification have been increasingly recognized as key regulators of diseases, yet their integrative role in periodontitis remains unclear. No diagnostic model based on exosome-related lactylation genes (ERLGs) has been previously established for periodontitis. This study aimed to explore ERLGs as potential diagnostic biomarkers for periodontitis. - Source: PubMed
Publication date: 2025/12/30
Liang XueyiFu RunxiChen Xiaochuan