EWS _ EWSR1
- Known as:
- EWS _ EWSR1
- Catalog number:
- Y214147
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- EWS _ EWSR1
Related genes to: EWS _ EWSR1
- Gene:
- EWSR1 NIH gene
- Name:
- EWS RNA binding protein 1
- Previous symbol:
- -
- Synonyms:
- EWS
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-04-25
Related products to: EWS _ EWSR1
Related articles to: EWS _ EWSR1
- Ewing sarcoma belongs to the family of undifferentiated small round cell sarcomas of bone and soft tissue. It is characterized by a gene fusion involving EWSR1 and an ETS-family transcription factor gene. In 85-96% of cases, a specific chromosomal translocation results in the EWSR1-FLI1 fusion gene, whose product functions as an oncogene essential for tumorigenesis. Ewing sarcoma is most common in adolescents and young adults. It primarily affects the diaphyses of long bones, the pelvis, and the axial skeleton, although extraosseous involvement is not uncommon. This is a highly malignant neoplasm, and in most cases, micrometastases are already present at the time of diagnosis. The treatment is multimodal and includes local therapy (surgery and/or radiotherapy) and systemic chemotherapy. One of the greatest therapeutic challenges remains the long-term systemic control of the disease. To improve overall survival - especially in high-risk patients - innovative treatment strategies are essential, as the potential for intensifying chemotherapy has reached its limit due to treatment-related toxicity. Both diagnostic and therapeutic management should take place in specialized sarcoma centers. - Source: PubMed
Nohejlová Medková APacas PKopečková K - The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib delays disease progression in dedifferentiated liposarcoma (DDLPS) by inducing tumor cell quiescence or senescence, though most tumors ultimately progress. Preclinical data suggest CDK4/6 inhibition enhances intratumoral inflammation and may synergize with immune checkpoint inhibitors. - Source: PubMed
Publication date: 2026/05/04
Rosenbaum EvanSeier KennethGularte-Mérida RodrigoSeffar EvanDickson Mark AAvutu ViswatejBanks Lauren BChan Jason EChi PingGounder Mrinal MKelly Ciara MKeohan Mary LMaki Robert GMovva SujanaReed DamonDesir RhoenaBiniakewitz MatthewCho Jae-MunDuchemin MicheleErinjeri Joseph PLefkowitz Robert AKoff AndrewSinger SamuelTap WilliamQin Li-XuanD'Angelo Sandra - Hyalinizing clear-cell carcinoma (HCCC) is a rare malignant tumor of the minor salivary glands characterized by nests of clear cells within a hyalinized stroma. Its diagnosis remains challenging due to its histological similarity to other neoplasms, and the recent recognition of distinct molecular features, such as Ewing sarcoma breakpoint region 1 (-activating transcription factor 1 () fusion. This report describes a rare case of HCCC arising from the tongue with confirmed fusion. - Source: PubMed
Publication date: 2026/05/01
Sakuma KanameTakahashi HarukaHanada DaichiKikuchi YosukeOno JunyaToya ShujiOkada YasuoTanaka Akira - We report the clinicopathologic features of EWSR1-rearranged renal neoplasia from our institution. A retrospective cohort of 39 EWSR1-rearranged renal tumors was identified using fluorescence in situ hybridization (FISH) and RNA-based next generation sequencing (NGS). A final diagnosis of Ewing sarcoma (EWS) was established in 34 of 39 cases (87%), with the remaining cases diagnosed as desmoplastic small round cell tumor (DSRCT; n=2), sclerosing epithelioid fibrosarcoma (SEF; n=2), and thyroid-like follicular renal cell carcinoma (TLFRCC; n=1). Fusion partners identified in EWS included FLI1 (n=17) and ERG (n=2). WT1 (n=2), CREB3L1 (n=1) and CREB3L2 (n=1), and PATZ1 (n=1) fusions were found in DSRCT, SEF, and TLFRCC, respectively. The mean age at EWS diagnosis was 31.4 years (range 6-73), with a similar sex distribution (18 females, 16 males), and a mean tumor size of 10.7 cm (range 3-24 cm). Both DSRCT cases occurred in males aged 6 and 29 years, diagnosed on renal biopsy and brain metastasis, respectively. The SEF cases involved primary tumors in 22-year-old and 43-year-old females. The one case of TLFRCC was identified in a 41-year-old female that underwent radical nephrectomy. Cases with available immunohistochemistry showed most EWS tumors (24/26, 92%) expressed a combination of CD99, FLI1, and ERG, while both SEF cases were positive for MUC4. Our results highlight the importance of molecular testing in providing an integrated diagnosis and are informative regarding the spectrum of renal neoplasia that harbor EWSR1 rearrangements, including EWS, DSRCT, SEF, and TLFRCC as these tumors can exhibit significant clinicopathologic heterogeneity. - Source: PubMed
Publication date: 2026/04/29
Colef Robert GPujari Ganesh PSill Daniel RPitel Beth AZhang PingchuanTekin BurakLucas Peter CWhaley Rumeal DHerrera Hernandez LorenJimenez Rafael EErickson Lori ACheville John CKipp Benjamin RHalling Kevin CGreipp Patricia TGupta Sounak - Cytogenetics analysis of adipocytic tumours revealed varieties of chromosomal translocations beyond MDM2 amplification, so, this report aimed to identify these translocations and recognise the altered genes with their fusion partners. - Source: PubMed
Atta I SShafek S IAbdel-Hamid M