C4orf14 _ AtNOS1
- Known as:
- C4orf14 _ AtNOS1
- Catalog number:
- Y214140
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C4orf14 _ AtNOS1
Related genes to: C4orf14 _ AtNOS1
- Gene:
- NOA1 NIH gene
- Name:
- nitric oxide associated 1
- Previous symbol:
- C4orf14
- Synonyms:
- MGC3232, hAtNOS1, hNOA1, MTG3
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-28
- Date modifiied:
- 2018-07-23
Related products to: C4orf14 _ AtNOS1
Related articles to: C4orf14 _ AtNOS1
- - Source: PubMed
Grohs CécileCapitan Aurélien - Nitric oxide (NO) is a multiregulatory signal molecule that integrates development and stress responses. To elucidate the molecular mechanisms of NO phytoeffects and to identify NO-associated genes, both genetic screens and genome-wide transcriptome analysis have been employed in numerous studies. Forward genetic screens have linked NO signalling to key biological processes, such as photosynthesis, cytokinin metabolism, stress adaptation, and cell cycle regulation. Reverse genetics has further characterized the role of NO-related genes involved in NO biosynthesis (e.g., NIA1/NIA2, NOA1), signalling (e.g., GSNOR, NPR1), stress responses (e.g., ABI4, RBOHD), and development (e.g., HO1, NOX1). Across multiple plant species, high-throughput transcriptomic techniques have identified thousands of NO-responsive genes involved mainly in hormonal signalling, carbohydrate metabolism, cell wall formation and stress responses. Beyond transcriptional control, NO has been found to influence gene expression through epigenetic mechanisms, such as histone acetylation and methylation, as well as DNA methylation. Nitric oxide also modifies key transcription factor families, altering their stabilities, DNA-binding capacity, and protein-protein interactions. Overall, this review underscores the central role of NO in modulating gene expression through multiple regulatory layers in plants. - Source: PubMed
Publication date: 2025/10/16
Széles EszterKondak DóraDa Silva Rafael CaetanoSzabados LászlóLindermayr ChristianKolbert Zsuzsanna - Nitric oxide (NO) is a key signaling molecule and is known to modulate diverse physiological processes, including defense responses against pathogens. However, the molecular mechanism underlying NO-induced plant immunity remains largely elusive. Here, we investigated the dynamics of NO biosynthesis and its downstream signaling through S-nitrosoproteome analysis of two rice cultivars, Dongjin (DJ, resistant) and Nipponbare (NIP, susceptible), in response to Magnaporthe oryzae, the causative agent of the rice blast disease. M. oryzae inoculation triggered relatively higher nitric oxide synthase (NOS/NOA1)-mediated NO biosynthesis in DJ than that of NIP. High-throughput, site-specific S-nitrosoproteome analysis using the iodoTMT-based mass spectrometry approach led to the identification of 511 S-nitrosated peptides corresponding to 335 proteins, representing the most comprehensive set of S-nitrosated peptides identified in rice so far. In particular, the S-nitrosated site intensity of superoxide dismutase (SOD) at Cysteine was significantly reduced specifically in DJ in response to pathogen inoculation. We observed that in vitro S-nitrosation of SOD enhances its activity, and its M. oryzae infection-triggered denitrosation was correlated with the S-nitrosoglutathione reductase (GSNOR) activation. This denitrosation-mediated suppression of SOD activity likely leads to the accumulation of superoxide ions during infection, which triggers immune responses. Altogether, our results suggest that NO-mediated S-nitrosation of SOD plays a crucial role in orchestrating redox-dependent defense signaling, which likely contributes to the contrasting resistance responses observed in the two cultivars. These findings provide novel insights into the functional implications of S-nitrosation in plant immunity and highlight redox-regulatory proteins as key targets of NO signaling during pathogen challenge. - Source: PubMed
Munir AdeelaMin Cheol WooWang YimingKim Sun TaeGupta Ravi - Prostatic diseases, consisting of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa), pose significant health challenges. While single-omics studies have provided valuable insights into the role of mitochondrial dysfunction in prostatic diseases, integrating multi-omics approaches is essential for uncovering disease mechanisms and identifying therapeutic targets. - Source: PubMed
Publication date: 2025/08/22
Gong BinbinYang FeixiangZhang NingWu ZhengyangLiu TianruiWang KunZhang XiangyuZhang YangyangSong ZhengyaoLiang Chaozhao - This study aims to identify genetic loci associated with age-related macular degeneration (AMD) and assess the interaction between genetic susceptibility and smoking history. - Source: PubMed
Publication date: 2025/07/29
Guo JuJiang YuhanXu XinranWang JianhuaYao XuemingWang XiaohongYang HongxiLi Mulin JYan Hua