TRPV3 (aa762_773)
- Known as:
- TRPV3 (aa762_773)
- Catalog number:
- Y214132
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- TRPV3 (aa762_773)
Related genes to: TRPV3 (aa762_773)
- Gene:
- TRPV3 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 3
- Previous symbol:
- -
- Synonyms:
- VRL3
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-05
- Date modifiied:
- 2016-10-05
Related products to: TRPV3 (aa762_773)
Related articles to: TRPV3 (aa762_773)
- Aromatic essential oils (EOs) exhibit anxiolytic properties, yet their neural and molecular mechanisms remain to be understood. Here, we found that citronellal, an EO derived from lemongrass, alleviates stress-related anxiety by modulating vagal tone. We identified transient receptor potential vanilloid 3 (TRPV3) channel in nodose ganglion (NG) as the molecular target of citronellal. TRPV3 was also observed to mediate the antistress effects of the inhaled anesthetic sevoflurane. Both sedatives attenuated acute restraint stress-induced hyperactivity of heart and breath rates via glutamatergic neurotransmission along NG-to-caudal nucleus tractus solitarius (cNTS) pathway. This effect was abolished by surgical vagotomy, , or NG-specific knockdown. Cryo-EM structural analysis revealed that sevoflurane occupies a pore-proximal fenestration site, while citronellal binds to the vanilloid site. Re-expression of wild-type TRPV3, but not loss-of-function TRPV3 mutants TRPV3(A560L) or TRPV3(V662A), in NG neurons restored the mouse's response to both sedatives, thereby modulating heart and respiratory rates. Together, these findings establish peripheral TRPV3 as a multisensory ligand-gated node for vagal modulation of stress responses, and help instruct pathway-specific anxiolytics. - Source: PubMed
Publication date: 2026/04/16
Wang PeiyuZhu JinpiaoLu XutengChen ChangGao BominTao WanjiangXia KeyuSong YangShi QiongGai HongcunXiao PanhaoLiu FengPang PeiyuanLi YangMo XiaoyiWang Xiao-DongXie ChangLi DongdongZhang ZongzeYao Jing - Enteric methane emissions from ruminants represent a significant contributor to agricultural greenhouse gases, necessitating precise genetic tools to guide mitigation strategies. This study aimed to identify genomic regions and estimate heritability parameters associated with methane-related traits in cattle through an integrated meta-analytical framework. The meta-analysis of the genome-wide association studies (meta-GWAS) was carried out with the METAL software, combining SNP level data extracted from published studies. Simultaneously, a distinct random effects meta-analysis of genomic and pedigree-based heritability estimates was performed using Comprehensive Meta-Analysis software. Functional analysis of the post-GWAS, including: Gene Ontology, KEGG, and network-based enrichment analysis, was also performed to describe the biological context of significant genes. The meta-GWAS identified 74 significant SNPs that were significant for the traits of methane, which are related to 113 candidate genes. Functional enrichment analyses revealed pathways related to metabolism, immune response, ion transport, and host-microbiome interactions. The KEGG metabolic pathway emerged as a highly enriched term, encompassing key genes such as: ALDH7A1, CYP51A1, P4HA2, and SHPK, which are involved in amino acid catabolism, lipid processing, and redox regulation functions critical to energy balance and digestive efficiency. Network analysis with Cytoscape has revealed TRPV3, TRPV1, ANK3, PKD2 and SHPK as network hub genes. Heritability meta-analysis indicated that methane production exhibited the moderate genomic (h2 = 0.296) and pedigree-based (h2 = 0.299) heritability estimations, and methane yield was also found to have moderate and high heritability. The findings highlight the potential for methane-related traits as viable targets for genetic selection. This research demonstrates the value of integrating functional genomics and quantitative genetic approaches to enhance understanding of the biological and heritable components of methane emissions, providing a robust foundation for an environmentally sustainable livestock breeding program. - Source: PubMed
Publication date: 2026/04/10
Golpasand SareGhavi Hossein-Zadeh NavidGhovvati Shahrokh - Following their domestication, chickens were translocated around the world to novel environments. Through a combination of natural and artificial selection, chickens adapted to these local conditions, creating significant genetic diversity across populations worldwide. Studying this diversity in the context of local environmental conditions may offer insights into mechanisms of adaptation to environmental stressors. In this study, we analyzed genomic data from the Chicken Genomic Diversity Consortium, applying multiple statistical approaches, including fixation index (F), nucleotide diversity (π), Tajima’s D, and runs of homozygosity (ROH), to identify selective sweeps among indigenous chickens from Afghanistan, China, Indonesia, Iran and Pakistan, compared with White Leghorn chickens. We identified sweeps in 14 genes related to heat tolerance, associated with relevant gene ontology (GO) terms and located within ROH regions. These genes, such as , , , , , , , , , , , , , , and play crucial roles in calcium signaling pathways, thermal sensation, and the plasticity of neurodevelopmental processes. These findings illustrate the significant role of selection in shaping genomic differentiation across chicken populations and provide insights into the genetic basis of adaptation to environmental stressors. - Source: PubMed
Publication date: 2026/04/07
Hosseinzadeh SevdaRafat Seyed AbbasJavanmard ArashHasanpur KarimBardou PhilippeCharles MathieuKlopp ChristopheSmith Adrian LFiddaman Steven R - TRPV3 is a thermosensitive and non-selective cation channel activated at physiological temperatures. It is abundantly expressed in skin keratinocytes, and point mutations in TRPV3 cause a rare genetic disorder, a channelopathy known as Olmsted Syndrome (OS). TRPV3-mutations that cause Olmsted Syndrome show major defects in lysosomal functions and many other cellular abnormalities, such as defects in cell adhesion, cell size and mitochondrial metabolism. In this work, we used a library of thermosensitive organelle probes to explore the sub-cellular thermal spectrum of the OS-causing TRPV3 mutant expressing cells and TRPV3-WT expressing cells in the model of a human keratinocyte cell line (HaCaT). We observe a drastic deviation in the thermal spectrum among the sub-cellular organelles in the cells expressing OS-mutants from the cells expressing WT-TRPV3 on a relative scale. Notably, cells expressing different OS-mutants display a lower temperature of the nucleus, irrespective of the position of the point mutation in TRPV3. In addition, higher temperatures of the ER, plasma membrane and lysosomes were observed, but such changes are dependent on the mutation. Our data confirm that disease-causing mutations in TRPV3 alter the "thermal spectrum" of the cells. This is the first evidence demonstrating the "genetic regulation" of thermal homeostasis at the cellular level and the involvement of TRPV3 in such function. These findings may have significance in deciphering the regulation of thermal homeostasis within the different subcellular organelles in general and demonstrate the importance of the thermosensitive ion channel TRPV3 in such a process. - Source: PubMed
Publication date: 2026/04/01
Chattapadhya AnupriyaSahu Ram PrasadDas Nilesh KumarChang Young-TaeGoswami Chandan - Frankincense, a traditional Chinese medicinal resin with well-documented skin barrier-protective and anti-inflammatory properties, has elusive underlying mechanisms in psoriasis-like dermatitis. This study aimed to elucidate its therapeutic potential and molecular targets by investigating frankincense oil extract (FOE) and three key constituents (linalool, α-pinene and 1-octanol) in a classic imiquimod-induced murine psoriasis model, with clinical first-line topical drugs (calcipotriol, tapinarof and dithranol) used as positive controls. Phenotypically, FOE and its constituents significantly ameliorated core psoriasis symptoms (desquamation, erythema, epidermal thickening and splenomegaly) at an efficacy comparable to that of positive controls. FOE suppressed epidermal hyperproliferation and dermal inflammatory infiltration, attenuated the abnormally elevated epidermal expression of TRPV3, β-catenin and COX-2, and increased the expression of the barrier protein K10. Taken together, these findings suggest that FOE restores impaired epidermal barrier function by regulating TRPV3, β-catenin, COX-2 and K10 expression, providing a novel mechanistic basis for the clinical application of traditional frankincense in psoriasis and identifying promising targets for antipsoriatic-drug development. - Source: PubMed
Publication date: 2026/03/13
Li Wen-JingWen Li-YingLi Yu-SangTang He-Bin