ITIH4
- Known as:
- ITIH4
- Catalog number:
- Y214101
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ITIH4
Related genes to: ITIH4
- Gene:
- ITIH4 NIH gene
- Name:
- inter-alpha-trypsin inhibitor heavy chain 4
- Previous symbol:
- ITIHL1
- Synonyms:
- IHRP, H4P
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-30
- Date modifiied:
- 2019-03-08
Related products to: ITIH4
anti-Bovine ITIH4, Bovine-ITIH4(Inter-Alpha-Trypsin Inhibitor H4) Host: Goat Unconjugated A.P.anti-Bovine ITIH4, Bovine-ITIH4(Inter-Alpha-Trypsin Inhibitor H4) Host: Rabbit Unconjugated A.P.anti-ITIH4 (C-Terminus)anti-ITIH4 (C-Terminus)anti-ITIH4 (Internal)Anti-ITIH4, Goat Polyclonal to ITIH4, Isotype , Host GoatAnti-ITIH4, Goat Polyclonal to ITIH4, Isotype , Host GoatAntibodies: ITIH4 (aa890-903) HOST: Goat Clonality: pAbAntibodies: Itih4 (mouse) HOST: Goat Clonality: pAbAntibodies: ITIH4 HOST: Goat Clonality: pAbAntibody to Inter Alpha-Globulin Inhibitor H4 (ITIH4) Organism: Homo sapiens (Human) Type: Polyclonal Source: RabbitAntibody to Inter Alpha-Globulin Inhibitor H4 (ITIH4) Organism: Homo sapiens (Human) Type: Polyclonal Source: RabbitBiotin-linked Antibody to Inter Alpha-Globulin Inhibitor H4 (ITIH4); Reactivity: Homo sapiens (Human) Clonality: Polyclonal Source: RabbitBovine inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) (ITIH4) ELISA kit, Species Bovine, Sample Type serum, plasmaBovine Inter-alpha-trypsin inhibitor H4 (ITIH4) ELISA KIT Related articles to: ITIH4
- Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition characterized by marked clinical and biological heterogeneity. Despite substantial progress in genetic discovery, the downstream biological mechanisms linking genetic risk to neurodevelopmental pathology remain incompletely understood. - Source: PubMed
Publication date: 2026/04/20
Wang GuoqiZhu GangHongyan LiuWu LiuliuZhang ZiyanPang PingSi ShuchengYang Guang - Many biomarkers have been evaluated as potential early detection markers for ovarian cancer. Better understanding of factors associated with inter-individual variation in circulating concentrations of these biomarkers is useful for optimizing their clinical utility for early detection. The study objective was to characterize the associations of sociodemographic-, lifestyle-, and health-related factors in relation to circulating ovarian biomarker concentrations in cancer-free women. - Source: PubMed
Publication date: 2026/04/22
Akonde MaxwellGraybill Whitney SpannuthClay-Gilmour AlyssaZhang JiajiaAlberg Anthony J - Circulating proteomics acts as an intermediate phenotype linking genetic susceptibility to MASLD. However, current evidence rarely establishes a direct concordance between serum protein levels and hepatic gene expression. We aimed to perform a multi-cohort joint analysis of serum proteomics and transcriptomics to characterize essential molecular features for MASLD. - Source: PubMed
Publication date: 2026/04/17
Xu JinjianGou WanglongWang XinyueRu DongmeiHu WeiChen JietengLi Bang-YanXi YueZheng Ju-ShengChen Yu-Ming - Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an acute phage protein and secretory protein that is highly related to inflammation. However, the expression profile and function of ITIH4 in macrophage-mediated inflammation are still unclear. - Source: PubMed
Publication date: 2026/04/17
Li JingZhao ZhuoqiFei JunZhang RuiPan LiyaXiang YingHong LiZhan Zhiyan - Acute pancreatitis (AP) is an inflammatory disorder of the pancreas lacking specific therapy and frequently complicated by oxidative stress (OS) and long-term endocrine dysfunction, including pancreatogenic diabetes. Pomegranate-derived nanovesicles (NVs) contain bioactive lipids, proteins, and metabolites responsible for many health benefits of pomegranate juice. This study evaluated whether prophylactic NVs administration could mitigate pancreatic injury, OS, systemic inflammation, and subsequent endocrine impairment in a murine model of severe L-arginine-induced AP. Male C57BL/6J mice were distributed to three groups: control, AP, and AP + NVs. A single subcutaneous dose of NVs (10 µg; ≈ 5 × 10 particles) was administered 2 h before AP induction via intraperitoneal L-arginine. Animals were analyzed at 3, 7, 30, and 60 days post-induction. NVs were isolated using differential centrifugation, tangential-flow filtration, and size-exclusion chromatography. NVs pretreatment preserved pancreatic architecture, reduced edema, amylase activity, and interleukin 6 (IL-6) levels in both tissue and plasma by limiting nuclear factor-κB-p65 phosphorylation. NVs restored redox balance by upregulating NQO1 [NAD(P)H quinone dehydrogenase 1], improving oxidized glutathione (GSSG)/reduced glutathione (GSH) and homocystine/homocysteine ratios, and maintaining PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) expression. NVs protected β-cell mass, enhanced insulin secretion, and normalized glucose tolerance after AP. Proteomic profiling revealed that NVs changed extracellular vesicle composition, lowering pro-inflammatory markers [fibronectin, dipeptidyl peptidase-4 (DPP4)] and restoring anti-inflammatory ITIH4 (inter-alpha-trypsin inhibitor protein heavy chain 4). NVs exert anti-inflammatory and antioxidant protection in experimental AP and preserve long-term endocrine function, highlighting their potential as a natural nanotherapeutic strategy to prevent pancreatic injury and post-pancreatitis diabetes. - Source: PubMed
Publication date: 2026/03/10
Torres-Cuevas IsabelSánchez-López Christian MMarcilla AntonioPérez Salvador