FRMPD1
- Known as:
- FRMPD1
- Catalog number:
- Y214089
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- FRMPD1
Related genes to: FRMPD1
- Gene:
- FRMPD1 NIH gene
- Name:
- FERM and PDZ domain containing 1
- Previous symbol:
- -
- Synonyms:
- KIAA0967, FRMD2
- Chromosome:
- 9p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-05
- Date modifiied:
- 2016-10-05
Related products to: FRMPD1
Related articles to: FRMPD1
- Aberrant ubiquitination drives hepatocellular carcinoma (HCC) progression, yet the role of FBXO10-a key F-box E3 ubiquitin ligase component-remains uncharacterized. Through bioinformatics analyses and functional validation, we establish FBXO10 as a critical oncogenic driver in HCC. Transcriptomic data from public databases (TIMER, UALCAN, GEO) revealed significant FBXO10 upregulation in HCC tissues, with elevated expression predicting advanced tumor stage, metastasis, and reduced survival. Functionally, FBXO10 silencing suppressed HCC cell proliferation while its overexpression promoted tumor growth. Mechanistic studies revealed that FBXO10 directly interacts with FRMPD1 to mediate its K63-linked polyubiquitination and stabilization, independent of transcriptional regulation. FRMPD1 restoration rescued FBXO10-mediated proliferation, confirming its role as the key downstream effector. Clinically, FBXO10 expression correlated with TP53 mutations and adverse clinicopathological features. Our findings reveal a novel FBXO10-FRMPD1 axis promoting hepatocarcinogenesis through post-translational stabilization, positioning FBXO10 as both a prognostic biomarker and therapeutic target in HCC. - Source: PubMed
Publication date: 2025/05/24
Liu WuguangXu BinKifayat KashifXie YuhongLiu XiaolongDong ChengyongWang Liming - Prostate cancer (PCa) is a significant cause of male mortality worldwide. Since metastases are the underlying cause of lethality, identifying markers for metastatic potential would be highly valuable. To address this issue, we set out to identify protein-coding genes with metastasis-specific expression changes in PCa. We employed a previously reported unique cohort consisting of metastases from castration-resistant prostate cancer (mCRPC) and matching primary tumors. Our comprehensive gene expression analyses identified 85 differentially expressed genes (DEGs) associated specifically with mCRPC, comprising 63 upregulated and 22 downregulated genes. Investigation of the transcription factors (TFs), such as the androgen receptor and its co-regulators FOXA1 and HOXB13, known to be important in prostate tumorigenesis, revealed their involvement in the differential expression of these genes. Furthermore, we identified enriched binding sites for nine TFs, namely EZH2, SUZ12, TLE3, TP63, CBX7, RNF2, SP140, JARID2, and CBX8, in the regulatory regions of the DEGs. Analysis of progression-free survival of prostatectomy-treated men highlighted 16 DEGs with significant prognostic value. Of these, three genes (FRMPD1, TMEM18, and ZNHIT3) were independent prognostic markers of biochemical recurrence. TMEM18 has putative androgen receptor-binding sites in its promoter region, and analysis of LNCaP cells following stimulation with dihydrotestosterone revealed a significant upregulation of TMEM18, confirming the androgen regulation of the gene. Furthermore, we confirmed the prognostic significance of TMEM18 expression at the protein level with immunohistochemistry (IHC) in a primary PCa tumor cohort. In conclusion, we identified 85 mCRPC-associated genes and showed that TMEM18 has prognostic value in early PCa. - Source: PubMed
Publication date: 2025/06/26
Sattari MinaRauhala HannaLatonen LeenaIsaacs William BNykter MattiBova G StevenKesseli JuhaVisakorpi Tapio - DNA-based prediction of externally visible characteristics (EVC) with SNPs is one of the research areas of interest in the forensic field. Based on a previous study performing GWAS on facial traits in a Korean population, herein, we present results stemming from GWA analysis with KoreanChip and novel genetic loci satisfying genome-wide significant level. We discovered a total of 20 signals and 12 loci were found to have novel associations with facial traits, including six loci located in intergenic regions and six loci located at UBE2O, HECTD2, CCDC108, TPK1, FCN2, and FRMPD1. Additionally, we performed a polygenic score analysis for 33 distance-related traits in facial phenotyping and determined genetic relationships between facial traits and SNPs using the GCTA program. The results of the current study offer an understanding of how facial morphology is influenced by complex genetic structures and provide insights into forensic investigation and population genetics. - Source: PubMed
Publication date: 2023/09/19
Cho Hye-WonBan Hyo-JeongJin Hyun-SeokCha SeongwonEom Yong-Bin - Trafficking of transducin (Gα) in rod photoreceptors is critical for adaptive and modulatory responses of the retina to varying light intensities. In addition to fine-tuning phototransduction gain in rod outer segments (OSs), light-induced translocation of Gα to the rod synapse enhances rod to rod bipolar synaptic transmission. Here, we show that the rod-specific loss of Frmpd1 (FERM and PDZ domain containing 1), in the retina of both female and male mice, results in delayed return of Gα from the synapse back to outer segments in the dark, compromising the capacity of rods to recover from light adaptation. Frmpd1 directly interacts with Gpsm2 (G-protein signaling modulator 2), and the two proteins are required for appropriate sensitization of rod-rod bipolar signaling under saturating light conditions. These studies provide insight into how the trafficking and function of Gα is modulated to optimize the photoresponse and synaptic transmission of rod photoreceptors in a light-dependent manner. - Source: PubMed
Publication date: 2022/10/17
Campla Christie KBocchero UlisseStrickland RyanNellissery JacobAdvani JayshreeIgnatova IrinaSrivastava DhirajAponte Angel MWang YuchenGumerson JessicaMartemyanov KirillArtemyev Nikolai OPahlberg JohanSwaroop Anand - The authors sought to examine whether brain activity is associated with treatment response to cognitive-behavioral therapy (CBT) in adolescents and adults with obsessive-compulsive disorder (OCD), and whether any associations are treatment specific relative to an active control psychotherapy (stress management therapy; SMT). - Source: PubMed
Publication date: 2020/08/28
Norman Luke JMannella Kristin AYang HuanAngstadt MikeAbelson James LHimle Joseph AFitzgerald Kate DTaylor Stephan F