ABCD4
- Known as:
- ABCD4
- Catalog number:
- Y214052
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCD4
Related genes to: ABCD4
- Gene:
- ABCD4 NIH gene
- Name:
- ATP binding cassette subfamily D member 4
- Previous symbol:
- PXMP1L
- Synonyms:
- PMP69, P70R, EST352188
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-27
- Date modifiied:
- 2016-10-05
Related products to: ABCD4
Related articles to: ABCD4
- Advanced paternal age compromises male fertility and correlates to a decline of the deacetylase SIRT1 activity, a central regulator of germline homeostasis and chromatin dynamics. Acetylation imbalance has been pointed out as a driver of testicular aging. We therefore asked whether SIRT1 insufficiency reproduces aging-associated shifts in the acetylation landscape and how these might propagate to sperm function, fertilization capacity and embryo development. To address this, we combined acetylomic profiling of / and naturally aged mice with functional assays of sperm quality and in vitro fertilization (IVF). Both and aged wild type (WT) testes shared a distinct acetylation signature absent in young WT controls, including nuclear regulators (ZNF638, MORC4), proteins involved in sperm structure and motility (Rootletin, Kinectin, CFAP58), and phosphoinositide signaling mediators such as PLCη1, which regulate intracellular Ca release. Conversely, 22 proteins displayed acetylation exclusively in WT controls but were absent in and aged testes, encompassing modules related to flagellar organization (CEP170, CEP350, AKAP13), meiotic control (ANAPC7, PDS5B, ESCO1, CENPE), signaling and metabolism (SHIP1, GAK, ABCD4), chromatin regulation (BRD4, MAGEB4), and testicular architecture (MFAP2). This differential acetylomic profile persisted in mature sperm, with / males showing elevated acLys levels and, more specifically, midpiece-restricted α-tubulin hyperacetylation, a pattern particularly shared with aged cohorts. Notably, this tubulin hyperacetylation remained after capacitation and correlated with mitochondrial dysfunction, elevated reactive oxygen species, reduced acrosome responsiveness, and diminished fertilization capacity. IVF assays further revealed decreased cleavage and blastocyst developmental rates, indicating defective paternal support of early embryogenesis despite preserved blastocyst quality. Together, these findings indicate that testicular SIRT1 contributes to germline acetylation patterns and that midpiece-restricted α-tubulin hyperacetylation is a shared feature of SIRT1 insufficiency and natural aging, correlating with the mitochondrial dysfunction and impaired sperm performance. Overall, our work broadens current understanding by integrating acetylomic and functional evidence within a model that reflects the physiological, age-related reduction of SIRT1. - Source: PubMed
Publication date: 2026/03/25
Iniesta-Cuerda MaríaValentova IvetaMoravec JiříLiška FrantišekKrálíčková MilenaKrapf DarioNevoral Jan - is a globally distributed whitefly species and a significant agricultural pest, yet the genomic and functional roles of its obligate endosymbiont remain poorly understood. The primary endosymbiont of whiteflies belongs to the genus Portiera. is essential for host survival, providing nutritional supplementation and facilitating ecological adaptation, but its evolutionary dynamics and host-specific adaptations in are largely unexplored. Comparative genomic studies of from other whitefly species have revealed distinct evolutionary patterns, yet no such data exist for , highlighting a critical knowledge gap. - Source: PubMed
Publication date: 2026/01/22
Wang Yu-YiChen Yi-JiaWang Hua-LingZhu Cheng-ChengLei TengLiu Yin-Quan - Pigs play a vital role in global food security as a major source of animal protein. Enhancing growth and reproductive traits is of great economic importance to the swine industry. To systematically identify genetic determinants underlying key economic traits, we performed an integrative multi-omics analysis in a population of 1624 Duroc pigs, focusing on backfat thickness (BF), loin muscle area (LMA), and total teat number (TTN). Our genome-wide association study (GWAS) identified twenty-one significant single nucleotide polymorphisms (SNPs)-fourteen for BF, three for LMA, and seven for TTN. Candidate genes located within 1 Mb of these SNPs, such as and for BF, for LMA, and and for TTN, were further investigated. Functional genomic annotations revealed that genetic variants near the significant SNPs were enriched in tissue-specific enhancer elements, implying regulatory potential. Transcriptome-wide association study (TWAS) further supported the candidate genes such as and for TTN and predicted several putative functional mutations that may affect transcription factor binding sites. This study demonstrates the power of integrative genomics to prioritize candidate genes and causal variants for animal complex traits, offering valuable resources for future precision breeding in pigs. - Source: PubMed
Publication date: 2025/12/17
Yan ZhuofanLi XiyueYang WenboZhou PengZhang WeiyaLi XinyunFu LiangliangLi JingjinDu Xiaoyong - Carcass composition traits, such as lean meat percentage, bone percentage, and number of ribs, are critical factors determining meat production and profitability of pigs. Traditional slaughter measurements are time-consuming, labor-intensive and invasive and cannot be evaluated on selection candidates. However, computed tomography scanning, a non-invasive technique, enables in vivo measurement of these traits, facilitating rapid accumulation of extensive phenotypic data. Despite these advances, the genetic mechanisms underlying computed tomography-based carcass traits remain largely unexplored. - Source: PubMed
Publication date: 2025/12/17
Han HeYu PengfeiZhang ZhenyangWei RanZhao WeiHou XiaoliangWang JianlanHe YongqiFu YanWang ZhenPan YuchunWang QishanZhang Zhe - Cobalamin J disease (CblJ) is an ultrarare autosomal recessive disorder of intracellular cobalamin metabolism associated with combined methylmalonic academia and homocystinuria (MAHCJ; 614857). - Source: PubMed
Publication date: 2025/02/27
Aslan DenizUctepe EyyupYesilyurt AhmetEsen Fatma NisaDalgıç Buket