COG8
- Known as:
- COG8
- Catalog number:
- Y214047
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- COG8
Related genes to: COG8
- Gene:
- COG8 NIH gene
- Name:
- component of oligomeric golgi complex 8
- Previous symbol:
- -
- Synonyms:
- FLJ22315, DOR1
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-09
- Date modifiied:
- 2014-11-18
Related products to: COG8
anti-COG8anti-COG8anti-COG8 type: Primary antibodies host: MouseBos taurus,Bovine,COG complex subunit 8,COG8,Component of oligomeric Golgi complex 8,Conserved oligomeric Golgi complex subunit 8Bovine component of oligomeric golgi complex 8 (COG8) ELISA kit, Species Bovine, Sample Type serum, plasmaBovine Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kitBovine Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kitBovine Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kit SpeciesBovineCanine Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kitCanine Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kitChicken Conserved oligomeric Golgi complex subunit 8(COG8) ELISA kitCOG complex subunit 8,COG8,Component of oligomeric Golgi complex 8,Conserved oligomeric Golgi complex subunit 8,Homo sapiens,HumanCOG complex subunit 8,Cog8,Component of oligomeric Golgi complex 8,Conserved oligomeric Golgi complex subunit 8,MNCb-5704,Mouse,Mus musculusCOG6 Gene component of oligomeric golgi complex 6COG8 antibody Isotype IgG Host Goat Related articles to: COG8
- Assisted reproduction technologies (ARTs) are generally considered safe; however, emerging evidence highlights the need to evaluate potential risks in adulthood to improve safety further. ART procedures like rederivation of embryos by vitrification differ from natural conditions, causing significant disparities between in vitro and in vivo embryos, affecting foetal physiology and postnatal life. This study aims to investigate whether hepatic transcriptome and metabolome changes observed postnatally are already present in foetal livers at the end of gestation. This study compared fresh and vitrified rabbit embryos, finding differences between foetuses obtained by the transfer of fresh and vitrified embryos at 24 days of gestation. Rederived embryos had reduced foetal and liver weights and crown-rump length. However, the offspring of vitrified embryos tended to be born with higher weight, showing compensatory growth in the final week of gestation (59.2 vs. 49.8 g). RNA-Seq analysis revealed 43 differentially expressed genes (DEGs) in the foetal liver of vitrified embryos compared to the fresh group. Notably, downregulated genes included BRAT1, CYP4A7, CYP2B4, RPL23, RPL22L1, PPILAL1, A1BG, IFGGC1, LRRC57, DIPP2, UGT2B14, IRGM1, NUTF2, MPST, and PPP1R1B, while upregulated genes included ACOT8, ERICH3, UBXN2A, METTL9, ALDH3A2, DERPC-like, NR5A2-like, AP-1, COG8, INHBE, and PLA2G4C. Overall, a functional annotation of these DEGs indicated an involvement in lipid metabolism and the stress and inflammatory process or immune response. Thus, our results suggest that vitrification and embryo transfer manipulation induce an adaptive response that can be observed in the liver during the last week of gestation. - Source: PubMed
Publication date: 2024/08/01
Vicente José SalvadorValdés-Hernández JesúsMarco-Jiménez Francisco - Whether alcohol-related DNA methylation has a causal effect on psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation into the causal relationship and underlying mechanisms linking alcohol consumption and psychiatric disorders has been lacking. This study aimed to evaluate the causal effect of general alcohol intake and pathological drinking behaviors on psychiatric disorders, alcohol-associated DNA methylation on gene expression and psychiatric disorders, and gene expression on psychiatric disorders. - Source: PubMed
Publication date: 2024/03/25
Shi XiaoqiangLi MengYao JianhuaLi Ming DYang Zhongli - Cerebrotendinous xanthomatosis () is a rare hereditary disease described by a mutation in the , which encodes the sterol 27-hydroxylase enzyme involved in the synthesis of bile acid. Accumulation of cholesterol and its metabolite, cholestanol, in multiple body organs causes the symptoms of this disease. In addition, a mutation in the , which encodes a subunit of conserved oligomeric Golgi (COG) complex, causes another rare disorder attributed to type IIh of congenital disorder of glycosylation (). We described a rare case of associated with a mutation on , which presented by unusual symptoms. - Source: PubMed
Ghoshouni HamedSarmadian RohamIrilouzadian RanaBiglari Habibe NejadGilani Abolfazl - Dermatomyositis is an autoimmune disease characterized by damage to the skin and muscles. CD4 T cells are of crucial importance in the occurrence and development of dermatomyositis (DM). However, there are few bioinformatics studies on potential pathogenic genes and immune cell infiltration of DM. Therefore, this study intended to explore CD4 T-cell infiltration-associated key genes in DM and construct a new model to predict the level of CD4 T-cell infiltration in DM. - Source: PubMed
Publication date: 2022/05/30
Huang PengTang LiZhang LuRen YiPeng HongXiao YangyangXu JieMao DinganLiu LingjuanLiu Liqun - Avian and human influenza viruses bind to porcine sialic acid receptors to generate novel viruses that pose a potential pandemic threat to public health. Evidence suggests that the host factors regulating the influenza virus life cycle and viral reassortment are potential broad-spectrum antiviral drug targets, compared to the ineffective seasonal vaccines against highly pathogenic viruses, leading to drug resistance. After performing a genome-wide CRISPR-Cas9 screen targeting 13,735 genes in porcine cell lines, we identified several host factors critical for influenza virus infection-notably, a conserved oligomeric Golgi complex protein, COG8, which regulates viral protein transport and immune factor expression. Viral titers indicated that the loss of significantly enhanced cellular resistance to influenza ( < 0.005). Moreover, knockout reduced the colocalization between viral particles and early endosome marker (EEA1), indicating COG8's role in the early endosome trafficking events of the virus. deletion inhibited the retrograde transport from the endosome to the trans-Golgi network, thereby accumulating the influenza protein M2 in early endosomes. silencing enhanced the expression of immune-related genes, indicating COG8-mediated host immune responses affect virus replication. Our experiments have revealed COG8 as an essential factor in influenza virus infection. - Source: PubMed
Zhou AoZhang WenhuaDong XiaTang Bin